L-selectin

Selectin L (lymphocyte adhesion molecule 1)
Identifiers
Symbols	SELL ; CD62L; LAM-1; LAM1; LECAM1; LNHR; LSEL; LYAM1; Leu-8; Lyam-1; PLNHR; TQ1; hLHRc
External IDs	Template:OMIM5 Template:MGI HomoloGene: 539
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SELL 204563 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognise sialylated carbohydrate groups. It is cleaved by ADAM17.

SELL is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins.

Ligands

• GlyCAM-1, found in the high endothelial venules of the lymph nodes.
• CD34, found on endothelial cells.
• MadCAM-1, found on endothelial cells of gut associated lymphoid tissue.
• PSGL-1, binds with low affinity.

Function

L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via the high endothelial venules. Ligands present on endothelial cells will bind to leukocytes expressing L-selectin, which causes the leukocytes to become localised at that point. The receptor is also found on the cell surfaces of "naive" T cells, which have not yet encountered their specific antigen. This surface expression is lost after the cells are activated.

External links

• L-Selectin at the US National Library of Medicine Medical Subject Headings (MeSH)
• Immunology at MCG 1/physresp

Further reading

• Ryan US, Worthington RE (1992). "Cell-cell contact mechanisms". Curr. Opin. Immunol. 4 (1): 33–7. PMID 1375831.
• Nicholson IC (2003). "CD62L (L-selectin)". J. Biol. Regul. Homeost. Agents. 16 (2): 144–6. PMID 12144128.
• Ivetic A, Ridley AJ (2005). "The telling tail of L-selectin". Biochem. Soc. Trans. 32 (Pt 6): 1118–21. doi:10.1042/BST0321118. PMID 15506984.
• Lasky LA, Singer MS, Dowbenko D; et al. (1992). "An endothelial ligand for L-selectin is a novel mucin-like molecule". Cell. 69 (6): 927–38. PMID 1376638.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ord DC, Ernst TJ, Zhou LJ; et al. (1990). "Structure of the gene encoding the human leukocyte adhesion molecule-1 (TQ1, Leu-8) of lymphocytes and neutrophils". J. Biol. Chem. 265 (14): 7760–7. PMID 1692315.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bevilacqua M, Butcher E, Furie B; et al. (1991). "Selectins: a family of adhesion receptors". Cell. 67 (2): 233. PMID 1717161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tedder TF, Isaacs CM, Ernst TJ; et al. (1989). "Isolation and chromosomal localization of cDNAs encoding a novel human lymphocyte cell surface molecule, LAM-1. Homology with the mouse lymphocyte homing receptor and other human adhesion proteins". J. Exp. Med. 170 (1): 123–33. PMID 2473156.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Camerini D, James SP, Stamenkovic I, Seed B (1989). "Leu-8/TQ1 is the human equivalent of the Mel-14 lymph node homing receptor". Nature. 342 (6245): 78–82. doi:10.1038/342078a0. PMID 2509939.CS1 maint: Multiple names: authors list (link)
• Bowen BR, Nguyen T, Lasky LA (1989). "Characterization of a human homologue of the murine peripheral lymph node homing receptor". J. Cell Biol. 109 (1): 421–7. PMID 2663882.CS1 maint: Multiple names: authors list (link)
• Siegelman MH, Weissman IL (1989). "Human homologue of mouse lymph node homing receptor: evolutionary conservation at tandem cell interaction domains". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5562–6. PMID 2664786.
• Bajorath J, Aruffo A (1995). "A template for generation and comparison of three-dimensional selectin models". Biochem. Biophys. Res. Commun. 216 (3): 1018–23. doi:10.1006/bbrc.1995.2722. PMID 7488174.
• Dianzani U, Bragardo M, Buonfiglio D; et al. (1995). "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". Eur. J. Immunol. 25 (5): 1306–11. PMID 7539755.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Brenner B, Gulbins E, Schlottmann K; et al. (1997). "L-selectin activates the Ras pathway via the tyrosine kinase p56lck". Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15376–81. PMID 8986819.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zöllner O, Lenter MC, Blanks JE; et al. (1997). "L-selectin from human, but not from mouse neutrophils binds directly to E-selectin". J. Cell Biol. 136 (3): 707–16. PMID 9024699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Prakobphol A, Thomsson KA, Hansson GC; et al. (1998). "Human low-molecular-weight salivary mucin expresses the sialyl lewisx determinant and has L-selectin ligand activity". Biochemistry. 37 (14): 4916–27. doi:10.1021/bi972612a. PMID 9538010.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sassetti C, Tangemann K, Singer MS; et al. (1998). "Identification of podocalyxin-like protein as a high endothelial venule ligand for L-selectin: parallels to CD34". J. Exp. Med. 187 (12): 1965–75. PMID 9625756.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin". Biochem. J. 341 ( Pt 1): 61–9. PMID 10377245.CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.