Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3gene.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR2DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the "framework" loci that is present on all haplotypes.
↑Long EO, Barber DF, Burshtyn DN, Faure M, Peterson M, Rajagopalan S, Renard V, Sandusky M, Stebbins CC, Wagtmann N, Watzl C (Aug 2001). "Inhibition of natural killer cell activation signals by killer cell immunoglobulin-like receptors (CD158)". Immunol Rev. 181: 223–233. doi:10.1034/j.1600-065X.2001.1810119.x. PMID11513144.
Dou LP, Zheng DH, Wang C, et al. (2008). "The diversity of KIR gene in Chinese Northern Han population and the impact of donor KIR and patient HLA genotypes on outcome following HLA-identical sibling allogeneic hematopoietic stem cell transplantation for hematological malignancy in Chinese people". Int. J. Hematol. 87 (4): 422–433. doi:10.1007/s12185-008-0058-7. PMID18347914.
Chen AM, Guo XM, Yan WY, et al. (2007). "[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 15 (1): 35–8. PMID17490516.
Zhu FM, Jiang K, Lü QF, et al. (2005). "[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population]". Zhongguo Shi Yan Xue Ye Xue Za Zhi. 13 (6): 1109–12. PMID16403292.
Trompeter HI, Gómez-Lozano N, Santourlidis S, et al. (2005). "Three structurally and functionally divergent kinds of promoters regulate expression of clonally distributed killer cell Ig-like receptors (KIR), of KIR2DL4, and of KIR3DL3". J. Immunol. 174 (7): 4135–43. doi:10.4049/jimmunol.174.7.4135. PMID15778373.
Arnheim L, Dillner J, Sanjeevi CB (2005). "A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia". Tissue Antigens. 65 (3): 252–259. doi:10.1111/j.1399-0039.2005.00359.x. PMID15730517.
Norman PJ, Carrington CV, Byng M, et al. (2002). "Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populations". Genes Immun. 3 (2): 86–95. doi:10.1038/sj.gene.6363836. PMID11960306.