CD32
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| Fc fragment of IgG, low affinity IIa, receptor (CD32) | |
|---|---|
| Identifiers | |
| Symbol | FCGR2A |
| Alt. symbols | FCG2, FCGR2A1, FCGR2 |
| Entrez | 2212 |
| HUGO | 3616 |
| OMIM | 146790 |
| RefSeq | NM_021642 |
| UniProt | P12318 |
| Other data | |
| Locus | Chr. 1 q23 |
| Fc fragment of IgG, low affinity IIb, receptor (CD32) | |
|---|---|
| File:CD32ray.png Crystal structure of the human fcgamma-receptor IIb ectodomain (CD32).[1] | |
| Identifiers | |
| Symbol | FCGR2B |
| Alt. symbols | FCG2, FCGR2 |
| Entrez | 2213 |
| HUGO | 3618 |
| OMIM | 604590 |
| RefSeq | NM_004001 |
| UniProt | P31994 |
| Other data | |
| Locus | Chr. 1 q23 |
| Fc fragment of IgG, low affinity IIc, receptor for (CD32) | |
|---|---|
| Identifiers | |
| Symbol | FCGR2C |
| Entrez | 9103 |
| HUGO | 15626 |
| RefSeq | NM_201563 |
| UniProt | P31995 |
| Other data | |
| Locus | Chr. 1 q23 |
CD32 is a surface receptor protein and part of a large population of B cell co-receptors, which act to modulate signaling.
It has a low-affinity for IgG antibodies and down-regulates antibody production in the presence of IgG. This feedback loop acts to lower the production of IgG by B cells when there is a surplus in the body. Monoclonal antibodies can distinguish between CD32A and CD32B.[2]
References
- ↑ PDB: 2FCB; Sondermann P, Huber R, Jacob U (March 1999). "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution". EMBO J. 18 (5): 1095–103. doi:10.1093/emboj/18.5.1095. PMC 1171201. PMID 10064577.; rendered via PyMOL.
- ↑ Veri MC, Gorlatov S, Li H, et al. (2007). "Monoclonal antibodies capable of discriminating the human inhibitory Fcgamma-receptor IIB (CD32B) from the activating Fcgamma-receptor IIA (CD32A): biochemical, biological and functional characterization". Immunology. 121 (3): 392–404. doi:10.1111/j.1365-2567.2007.02588.x. PMC 2265948. PMID 17386079.
External links
- CD32+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)
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