Syndecan 1
| Syndecan 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbols | SDC1 ; CD138; SDC; SYND1; syndecan | ||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 2252 | ||||||||
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| RNA expression pattern | |||||||||
| File:PBB GE SDC1 201286 at tn.png | |||||||||
| File:PBB GE SDC1 201287 s at tn.png | |||||||||
| More reference expression data | |||||||||
| Orthologs | |||||||||
| Template:GNF Ortholog box | |||||||||
| Species | Human | Mouse | |||||||
| Entrez | n/a | n/a | |||||||
| Ensembl | n/a | n/a | |||||||
| UniProt | n/a | n/a | |||||||
| RefSeq (mRNA) | n/a | n/a | |||||||
| RefSeq (protein) | n/a | n/a | |||||||
| Location (UCSC) | n/a | n/a | |||||||
| PubMed search | n/a | n/a | |||||||
Syndecan 1 is a proteoglycan.
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.[1]
References
Further reading
- David G (1992). "Structural and functional diversity of the heparan sulfate proteoglycans". Adv. Exp. Med. Biol. 313: 69–78. PMID 1442271.
- Jaakkola P, Jalkanen M (1999). "Transcriptional regulation of Syndecan-1 expression by growth factors". Prog. Nucleic Acid Res. Mol. Biol. 63: 109–38. PMID 10506830.
- Wijdenes J, Dore JM, Clement C, Vermot-Desroches C (2003). "CD138". J. Biol. Regul. Homeost. Agents. 16 (2): 152–5. PMID 12144130.
- Lories V, Cassiman JJ, Van den Berghe H, David G (1992). "Differential expression of cell surface heparan sulfate proteoglycans in human mammary epithelial cells and lung fibroblasts". J. Biol. Chem. 267 (2): 1116–22. PMID 1339431.
- Vainio S, Jalkanen M, Bernfield M, Saxén L (1992). "Transient expression of syndecan in mesenchymal cell aggregates of the embryonic kidney". Dev. Biol. 152 (2): 221–32. PMID 1644217.
- Kiefer MC, Ishihara M, Swiedler SJ; et al. (1992). "The molecular biology of heparan sulfate fibroblast growth factor receptors". Ann. N. Y. Acad. Sci. 638: 167–76. PMID 1664683.
- Ala-Kapee M, Nevanlinna H, Mali M; et al. (1990). "Localization of gene for human syndecan, an integral membrane proteoglycan and a matrix receptor, to chromosome 2". Somat. Cell Mol. Genet. 16 (5): 501–5. PMID 2173154.
- Mali M, Jaakkola P, Arvilommi AM, Jalkanen M (1990). "Sequence of human syndecan indicates a novel gene family of integral membrane proteoglycans". J. Biol. Chem. 265 (12): 6884–9. PMID 2324102.
- Sanderson RD, Lalor P, Bernfield M (1992). "B lymphocytes express and lose syndecan at specific stages of differentiation". Cell Regul. 1 (1): 27–35. PMID 2519615.
- Asundi VK, Carey DJ (1995). "Self-association of N-syndecan (syndecan-3) core protein is mediated by a novel structural motif in the transmembrane domain and ectodomain flanking region". J. Biol. Chem. 270 (44): 26404–10. PMID 7592855.
- Zhang L, David G, Esko JD (1995). "Repetitive Ser-Gly sequences enhance heparan sulfate assembly in proteoglycans". J. Biol. Chem. 270 (45): 27127–35. PMID 7592967.
- Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence". Proc. Natl. Acad. Sci. U.S.A. 90 (17): 7941–5. PMID 7690138.
- Spring J, Goldberger OA, Jenkins NA; et al. (1994). "Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family". Genomics. 21 (3): 597–601. doi:10.1006/geno.1994.1319. PMID 7959737.
- Sneed TB, Stanley DJ, Young LA, Sanderson RD (1994). "Interleukin-6 regulates expression of the syndecan-1 proteoglycan on B lymphoid cells". Cell. Immunol. 153 (2): 456–67. doi:10.1006/cimm.1994.1042. PMID 8118875.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Kokenyesi R, Bernfield M (1994). "Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1". J. Biol. Chem. 269 (16): 12304–9. PMID 8163535.
- Albini A, Benelli R, Presta M; et al. (1996). "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289–97. PMID 8570206.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
- Kaukonen J, Alanen-Kurki L, Jalkanen M, Palotie A (1997). "The mapping and visual ordering of the human syndecan-1 and N-myc genes near the telomeric region of chromosome 2p". Hum. Genet. 99 (3): 295–7. PMID 9050911.
External links
- Syndecan-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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