Phytohaemagglutinin

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Phytohaemagglutinin (PHA, or phytohemagglutinin) is a lectin found in plants, especially beans. It is found in the highest concentrations in uncooked red kidney beans (Phaseolus vulgaris), and it is also found in lower quantities in many types of green bean. It has a number of physiological effects and is used in medical research. In high doses it is a toxin.

Crystal structure of PHA-L (Protein Data Bank identifier 1FAT)

The lectin has a number of effects on cell metabolism: it induces mitosis, and affects the cell membrane in regard to transport and permeability to proteins. It agglutinates most mammalian red blood cell types.

As a toxin it can cause poisoning in monogastric animals, such as humans, through the consumption of raw or improperly prepared kidney beans. Measured in haemagglutinating units (hau) a raw kidney bean can contain up to 70,000 hau. This can be reduced around 200-fold by correct cooking. The bean also contains α-amylase inhibitor.

Poisoning can be induced from as few as five raw beans and symptoms occur within three hours, beginning with nausea then vomiting which can be severe and sustained (profuse), then diarrhea. Recovery occurs within four or five hours of onset, usually without the need for any medical intervention.

Medically it is used as a mitogen to trigger cell division in T-lymphocytes, and to activate latent HIV-1 from human peripheral lymphocytes.

PHA actually consists of two closely related proteins, called PHA-L and PHA-E. The letters E and L point to the fact that these proteins agglutinate Erythrocytes and Leukocytes, respectively.

References

  • Hamelryck T, Dao-Thi M, Poortmans F, Chrispeels M, Wyns L, Loris R (1996). "The crystallographic structure of phytohemagglutinin-L". J Biol Chem. 271 (34): 20479–85. PMID 8702788.

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| group5 = Clinical Trials Involving Phytohaemagglutinin | list5 = Ongoing Trials on Phytohaemagglutinin at Clinical Trials.govTrial results on PhytohaemagglutininClinical Trials on Phytohaemagglutinin at Google


| group6 = Guidelines / Policies / Government Resources (FDA/CDC) Regarding Phytohaemagglutinin | list6 = US National Guidelines Clearinghouse on PhytohaemagglutininNICE Guidance on PhytohaemagglutininNHS PRODIGY GuidanceFDA on PhytohaemagglutininCDC on Phytohaemagglutinin


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| group8 = Pharmacology Resources on Phytohaemagglutinin | list8 = AND (Dose)}} Dosing of PhytohaemagglutininAND (drug interactions)}} Drug interactions with PhytohaemagglutininAND (side effects)}} Side effects of PhytohaemagglutininAND (Allergy)}} Allergic reactions to PhytohaemagglutininAND (overdose)}} Overdose information on PhytohaemagglutininAND (carcinogenicity)}} Carcinogenicity information on PhytohaemagglutininAND (pregnancy)}} Phytohaemagglutinin in pregnancyAND (pharmacokinetics)}} Pharmacokinetics of Phytohaemagglutinin


| group9 = Genetics, Pharmacogenomics, and Proteinomics of Phytohaemagglutinin | list9 = AND (pharmacogenomics)}} Genetics of PhytohaemagglutininAND (pharmacogenomics)}} Pharmacogenomics of PhytohaemagglutininAND (proteomics)}} Proteomics of Phytohaemagglutinin


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| group13 = Healthcare Provider Resources on Phytohaemagglutinin | list13 = Symptoms of PhytohaemagglutininCauses & Risk Factors for PhytohaemagglutininDiagnostic studies for PhytohaemagglutininTreatment of Phytohaemagglutinin

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| group17 = Informatics Resources on Phytohaemagglutinin | list17 = List of terms related to Phytohaemagglutinin


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