FCGR2B

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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Low affinity immunoglobulin gamma Fc region receptor II-b is a protein that, in humans, is encoded by the FCGR2B gene. FCGR2B (CD32B) is a "low affinity" receptor for Immunoglobulin G (IgG). Mutation in the gene in humans leads to a lupus phenotype.[1][2] The cytoplasmic part of this receptor contains an immunoreceptor tyrosine-based inhibitory motif, in contrast to the activating isoform, FCGR2A (CD32A).


Function

The inhibitory CD32B is expressed on B cells and myeloid dendritic cells.[3] Ligation of CD32B on B cells downregulates antibody production and may, in some circumstances, promote apoptosis. Co-ligation of CD32B on dendritic cells inhibits maturation and blocks cell activation. CD32B may also be a target for monoclonal antibody therapy for malignancies.[4][5]

See also

References

  1. Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (Jun 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. doi:10.1126/science.2139735. PMID 2139735.
  2. "Entrez Gene: FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)".
  3. Boruchov AM, Heller G, Veri MC, Bonvini E, Ravetch JV, Young JW (2005). "Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions". J Clin Invest. 115 (10): 2914–23. doi:10.1172/JCI24772. PMC 1201664. PMID 16167082. open access publication – free to read (Free full text)
  4. Rankin CT, Veri MC, Gorlatov S, Tuaillon N, Burke S, Huang L, Inzunza HD, Li H, Thomas S, Johnson S, Stavenhagen J, Koenig S, Bonvini E (2006). "CD32B, the human inhibitory Fc-γ receptor IIB, as a target for monoclonal antibody therapy of B-cell lymphoma". Blood. 108 (7): 2384–91. doi:10.1182/blood-2006-05-020602. PMID 16757681. open access publication – free to read (Free full text)
  5. Zhou P, Comenzo RL, Olshen AB, Bonvini E, Koenig S, Maslak PG, Fleisher M, Hoffman J, Jhanwar S, Young JW, Nimer SD, Boruchov AM (2008). "CD32B is highly expressed on clonal plasma cells from patients with systemic light-chain amyloidosis and provides a target for monoclonal antibody–based therapy". Blood. 111 (7): 3403–6. doi:10.1182/blood-2007-11-125526. PMC 2275009. PMID 18216299. open access publication – free to read (Free full text)

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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