Tumor-associated calcium signal transducer 1

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Tumor-associated calcium signal transducer 1
Identifiers
Symbols TACSTD1 ; CD326; CO17-1A; EGP; EGP40; Ep-CAM; GA733-2; KSA; M4S1; MIC18; MK-1; TROP1; hEGP-2
External IDs OMIM: 185535 MGI106653 HomoloGene1764
RNA expression pattern
File:PBB GE TACSTD1 201839 s at tn.png
More reference expression data
Orthologs

| | bgcolor="#C3FDB8" | Human | bgcolor="#C3FDB8" | Mouse |-

    | bgcolor="#C3FDB8" | Entrez 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 4072
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| 17075

|-

     | bgcolor="#C3FDB8" | Ensembl
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSG00000119888
     | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| ENSMUSG00000045394

|-

    | bgcolor="#C3FDB8" | Uniprot
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| P16422
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| na

|-

    | bgcolor="#C3FDB8" | Refseq
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" | NM_002354 (mRNA)
NP_002345 (protein)
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd" |NM_008532 (mRNA)
NP_032558 (protein)

|-

    | bgcolor="#C3FDB8" | Location
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 2: 47.45 - 47.47 Mb 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"|  Chr 17: 87.55 -  87.56 Mb 

|-

|-

    | bgcolor="#C3FDB8" | Pubmed search 
    | bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [1]
| bgcolor="#eeeeee" style="border-top:2px solid #dddddd; border-right:2px solid #dddddd"| [2]
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Tumor-associated calcium signal transducer 1, also known as TACSTD1, is a human gene.[1] TACSTD1 has also been designated as CD326 (cluster of differentiation 326).


This 9-exon gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas.[1]

References

  1. 1.0 1.1 "Entrez Gene: TACSTD1 tumor-associated calcium signal transducer 1".

Further reading

  • Bergsagel PL, Victor-Kobrin C, Timblin CR; et al. (1992). "A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells". J. Immunol. 148 (2): 590–6. PMID 1729376.
  • Simon B, Podolsky DK, Moldenhauer G; et al. (1990). "Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2755–9. PMID 2108441.
  • Szala S, Froehlich M, Scollon M; et al. (1990). "Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3542–6. PMID 2333300.
  • Strnad J, Hamilton AE, Beavers LS; et al. (1989). "Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA". Cancer Res. 49 (2): 314–7. PMID 2463074.
  • Perez MS, Walker LE (1989). "Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker". J. Immunol. 142 (10): 3662–7. PMID 2469722.
  • Linnenbach AJ, Wojcierowski J, Wu SA; et al. (1989). "Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 27–31. PMID 2911574.
  • Spurr NK, Durbin H, Sheer D; et al. (1986). "Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI". Int. J. Cancer. 38 (5): 631–6. PMID 3770992.
  • Björk P, Jönsson U, Svedberg H; et al. (1993). "Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody". J. Biol. Chem. 268 (32): 24232–41. PMID 7693697.
  • Linnenbach AJ, Seng BA, Wu S; et al. (1993). "Retroposition in a family of carcinoma-associated antigen genes". Mol. Cell. Biol. 13 (3): 1507–15. PMID 8382772.
  • Zhong XY, Kaul S, Eichler A, Bastert G (2000). "Evaluating GA733-2 mRNA as a marker for the detection of micrometastatic breast cancer in peripheral blood and bone marrow". Arch. Gynecol. Obstet. 263 (1–2): 2–6. PMID 10728619.
  • Tomita Y, Arakawa F, Yamamoto T; et al. (2000). "Molecular identification of a human carcinoma-associated glycoprotein antigen recognized by mouse monoclonal antibody FU-MK-1". Jpn. J. Cancer Res. 91 (2): 231–8. PMID 10761711.
  • Trebak M, Begg GE, Chong JM; et al. (2001). "Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion". J. Biol. Chem. 276 (3): 2299–309. doi:10.1074/jbc.M004770200. PMID 11058587.
  • Chong JM, Speicher DW (2001). "Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)". J. Biol. Chem. 276 (8): 5804–13. doi:10.1074/jbc.M008839200. PMID 11080501.
  • Calabrese G, Crescenzi C, Morizio E; et al. (2001). "Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization". Cytogenet. Cell Genet. 92 (1–2): 164–5. PMID 11306819.
  • Meyaard L, van der Vuurst de Vries AR, de Ruiter T; et al. (2001). "The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR)". J. Exp. Med. 194 (1): 107–12. PMID 11435477.
  • Lammers R, Giesert C, Grünebach F; et al. (2002). "Monoclonal antibody 9C4 recognizes epithelial cellular adhesion molecule, a cell surface antigen expressed in early steps of erythropoiesis". Exp. Hematol. 30 (6): 537–45. PMID 12063020.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Spizzo G, Gastl G, Wolf D; et al. (2003). "Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival". Br. J. Cancer. 88 (4): 574–8. doi:10.1038/sj.bjc.6600741. PMID 12592372.
  • Nasr AF, Nutini M, Palombo B; et al. (2003). "Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene". Oncogene. 22 (11): 1668–77. doi:10.1038/sj.onc.1206248. PMID 12642870.
  • Gires O, Eskofier S, Lang S; et al. (2003). "Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter". Anticancer Res. 23 (4): 3255–61. PMID 12926061.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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