T-cell surface glycoprotein CD3 epsilon chain: Difference between revisions

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* {{cite journal | vauthors = DeNofrio D, Radcliff G, Weinhold KJ, Denning SM | title = CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors | journal = Human Immunology | volume = 43 | issue = 4 | pages = 283–94 | date = August 1995 | pmid = 7499176 | doi = 10.1016/0198-8859(95)91034-U }}
* {{cite journal | vauthors = DeNofrio D, Radcliff G, Weinhold KJ, Denning SM | title = CD3 delta and epsilon gene expression in CD3-CD16+ natural killer cell clones derived from thymic precursors | journal = Human Immunology | volume = 43 | issue = 4 | pages = 283–94 | date = August 1995 | pmid = 7499176 | doi = 10.1016/0198-8859(95)91034-U }}
* {{cite journal | vauthors = Kishimoto H, Kubo RT, Yorifuji H, Nakayama T, Asano Y, Tada T | title = Physical dissociation of the TCR-CD3 complex accompanies receptor ligation | journal = The Journal of Experimental Medicine | volume = 182 | issue = 6 | pages = 1997–2006 | date = December 1995 | pmid = 7500045 | pmc = 2192252 | doi = 10.1084/jem.182.6.1997 }}
* {{cite journal | vauthors = Kishimoto H, Kubo RT, Yorifuji H, Nakayama T, Asano Y, Tada T | title = Physical dissociation of the TCR-CD3 complex accompanies receptor ligation | journal = The Journal of Experimental Medicine | volume = 182 | issue = 6 | pages = 1997–2006 | date = December 1995 | pmid = 7500045 | pmc = 2192252 | doi = 10.1084/jem.182.6.1997 }}
* {{cite journal | vauthors = Oravecz T, Norcross MA | title = Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120 | journal = AIDS Research and Human Retroviruses | volume = 9 | issue = 10 | pages = 945–55 | date = October 1993 | pmid = 7506554 | doi = 10.1089/aid.1993.9.945 }}
* {{cite journal | vauthors = Oravecz T, Norcross MA | title = Costimulatory properties of the human CD4 molecule: enhancement of CD3-induced T cell activation by human immunodeficiency virus type 1 through viral envelope glycoprotein gp120 | journal = AIDS Research and Human Retroviruses | volume = 9 | issue = 10 | pages = 945–55 | date = October 1993 | pmid = 7506554 | doi = 10.1089/aid.1993.9.945 | url = https://zenodo.org/record/1235235/files/article.pdf }}
* {{cite journal | vauthors = Beecher MS, Baiocchi RA, Linett ML, Krajewski CA, Caligiuri MA | title = Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus | journal = Cellular Immunology | volume = 155 | issue = 2 | pages = 508–16 | date = May 1994 | pmid = 7514106 | doi = 10.1006/cimm.1994.1143 }}
* {{cite journal | vauthors = Beecher MS, Baiocchi RA, Linett ML, Krajewski CA, Caligiuri MA | title = Expression of the zeta protein subunit in CD3- NK effectors derived from human thymus | journal = Cellular Immunology | volume = 155 | issue = 2 | pages = 508–16 | date = May 1994 | pmid = 7514106 | doi = 10.1006/cimm.1994.1143 }}
* {{cite journal | vauthors = Luzzati AL, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, Pugliese O | title = An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex | journal = Cellular Immunology | volume = 156 | issue = 2 | pages = 286–95 | date = July 1994 | pmid = 7517794 | doi = 10.1006/cimm.1994.1175 }}
* {{cite journal | vauthors = Luzzati AL, Giacomini E, Giordani L, Viora M, Chersi A, Camponeschi B, Pugliese O | title = An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex | journal = Cellular Immunology | volume = 156 | issue = 2 | pages = 286–95 | date = July 1994 | pmid = 7517794 | doi = 10.1006/cimm.1994.1175 }}

Latest revision as of 03:19, 25 October 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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CD3e molecule, epsilon also known as CD3E is a polypeptide which in humans is encoded by the CD3E gene which resides on chromosome 11.[1][2]

Function

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development.[3]

Clinical significance

Defects in this gene cause severe immunodeficiency.[4][5] This gene has also been linked to a susceptibility to type I diabetes in women.[6]

Interactions

T-cell surface glycoprotein CD3 epsilon chain has been shown to interact with TOP2B,[7] CD3EAP[8] and NCK2.[9]

See also

References

  1. Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C (1986). "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex". Nature. 321 (6068): 431–4. doi:10.1038/321431a0. PMID 3012357.
  2. Clevers HC, Dunlap S, Wileman TE, Terhorst C (November 1988). "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter". Proceedings of the National Academy of Sciences of the United States of America. 85 (21): 8156–60. doi:10.1073/pnas.85.21.8156. PMC 282386. PMID 3267235.
  3. "Entrez Gene: CD3E CD3e molecule, epsilon (CD3-TCR complex)".
  4. Soudais C, de Villartay JP, Le Deist F, Fischer A, Lisowska-Grospierre B (January 1993). "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency". Nature Genetics. 3 (1): 77–81. doi:10.1038/ng0193-77. PMID 8490660.
  5. de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F (November 2004). "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3". The Journal of Clinical Investigation. 114 (10): 1512–7. doi:10.1172/JCI22588. PMC 525745. PMID 15546002.
  6. Wong S, Moore S, Orisio S, Millward A, Demaine AG (January 1991). "Susceptibility to type I diabetes in women is associated with the CD3 epsilon locus on chromosome 11". Clinical and Experimental Immunology. 83 (1): 69–73. doi:10.1111/j.1365-2249.1991.tb05590.x. PMC 1535466. PMID 1671006.
  7. Nakano H, Yamazaki T, Miyatake S, Nozaki N, Kikuchi A, Saito T (March 1996). "Specific interaction of topoisomerase II beta and the CD3 epsilon chain of the T cell receptor complex". The Journal of Biological Chemistry. 271 (11): 6483–9. doi:10.1074/jbc.271.11.6483. PMID 8626450.
  8. Yamazaki T, Hamano Y, Tashiro H, Itoh K, Nakano H, Miyatake S, Saito T (June 1999). "CAST, a novel CD3epsilon-binding protein transducing activation signal for interleukin-2 production in T cells". The Journal of Biological Chemistry. 274 (26): 18173–80. doi:10.1074/jbc.274.26.18173. PMID 10373416.
  9. Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (June 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell. 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. PMID 12110186.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.