SEMA7A: Difference between revisions

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Latest revision as of 06:06, 11 September 2017

Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) (SEMA7A) also known as CD108 (Cluster of Differentiation 108), is a human gene.^[1]

SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM]^[1]

Genetics

This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.

Molecular biology

This protein forms dimers.

Notes

This protein acts as a receptor for the malaria parasite Plasmodium falciparum.

References

↑ ^1.0 ^1.1 "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

Xu X, Ng S, Wu ZL, et al. (1998). "Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins". J. Biol. Chem. 273 (35): 22428–34. doi:10.1074/jbc.273.35.22428. PMID 9712866.
Lange C, Liehr T, Goen M, et al. (1998). "New eukaryotic semaphorins with close homology to semaphorins of DNA viruses". Genomics. 51 (3): 340–50. doi:10.1006/geno.1998.5256. PMID 9721204.
Yamada A, Kubo K, Takeshita T, et al. (1999). "Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108". J. Immunol. 162 (7): 4094–100. PMID 10201933.
Angelisová P, Drbal K, Cerný J, et al. (1999). "Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules". Immunobiology. 200 (2): 234–45. doi:10.1016/s0171-2985(99)80073-4. PMID 10416131.
Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995.
Mine T, Harada K, Matsumoto T, et al. (2000). "CDw108 expression during T-cell development". Tissue Antigens. 55 (5): 429–36. doi:10.1034/j.1399-0039.2000.550505.x. PMID 10885563.
Holmes S, Downs AM, Fosberry A, et al. (2002). "Sema7A is a potent monocyte stimulator". Scand. J. Immunol. 56 (3): 270–5. doi:10.1046/j.1365-3083.2002.01129.x. PMID 12193228.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Maurin JC, Delorme G, Machuca-Gayet I, et al. (2005). "Odontoblast expression of semaphorin 7A during innervation of human dentin". Matrix Biol. 24 (3): 232–8. doi:10.1016/j.matbio.2005.03.005. PMID 15907379.
Hu Y, Malone JP, Fagan AM, et al. (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid". Mol. Cell. Proteomics. 4 (12): 2000–9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
Koh JM, Oh B, Lee JY, et al. (2006). "Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women". J. Hum. Genet. 51 (2): 112–7. doi:10.1007/s10038-005-0331-z. PMID 16372136.

External links

SEMA7A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
John Milton Hagen blood group system in the BGMUT blood group antigen gene mutation database

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)".

[1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Semaphorin 7A, GPI membrane anchor''' ('''John Milton Hagen blood group''') ('''SEMA7A''') also known as '''CD108''' ('''C'''luster of '''D'''ifferentiation 108), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-| update_protein_box = yes
+{{PBB_Summary
-| update_summary = yes
+| section_title =
-| update_citations = yes
+| summary_text = SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}</ref>
 }}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
- | HGNCid = 10741
- | Symbol = SEMA7A
- | AltSymbols =; CD108; CDw108; H-SEMA-K1; H-Sema K1; H-Sema-L; JMH; MGC126692; MGC126696; SEMAK1; SEMAL
- | OMIM = 607961
- | ECnumber =
- | Homologene = 2678
- | MGIid = 1306826
- | GeneAtlas_image1 = PBB_GE_SEMA7A_210083_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
- | Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8482
-    | Hs_Ensembl = ENSG00000138623
-    | Hs_RefseqProtein = NP_003603
-    | Hs_RefseqmRNA = NM_003612
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 15
-    | Hs_GenLoc_start = 72489376
-    | Hs_GenLoc_end = 72513329
-    | Hs_Uniprot = O75326
-    | Mm_EntrezGene = 20361
-    | Mm_Ensembl = ENSMUSG00000038264
-    | Mm_RefseqmRNA = NM_011352
-    | Mm_RefseqProtein = NP_035482
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 57738272
-    | Mm_GenLoc_end = 57761002
-    | Mm_Uniprot = Q9QUR8
-  }}
-}}
-{{SI}}
-{{CMG}}
+==Genetics==
+This protein is known to have eight variants in the extracellular region: seven lie within the Sema domain and one within the PSI domain.
+==Molecular biology==
+This protein forms dimers.
-'''Semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)''' ('''SEMA7A''') also known as '''CD108''' ('''C'''luster of '''D'''ifferentiation 108), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}</ref>
+==Notes==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+This protein acts as a receptor for the malaria parasite ''[[Plasmodium falciparum]]''.
-{{PBB_Summary
-| section_title =
-| summary_text = SEMA7A is a membrane-bound semaphorin that associates with cell surfaces via a glycosylphosphatidylinositol (GPI) linkage. SEMA7A is also known as the John-Milton-Hagen (JMH) blood group antigen, an 80-kD glycoprotein expressed on activated lymphocytes and erythrocytes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8482| accessdate = }}</ref>
-}}
 ==See also==
@@ Line 62: / Line 24: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 68: / Line 30: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Xu X, Ng S, Wu ZL, ''et al.'' |title=Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22428-34 |year= 1998 |pmid= 9712866 |doi=  }}
+*{{cite journal   |vauthors=Xu X, Ng S, Wu ZL, etal |title=Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22428–34 |year= 1998 |pmid= 9712866 |doi=10.1074/jbc.273.35.22428  }}
-*{{cite journal  | author=Lange C, Liehr T, Goen M, ''et al.'' |title=New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. |journal=Genomics |volume=51 |issue= 3 |pages= 340-50 |year= 1998 |pmid= 9721204 |doi= 10.1006/geno.1998.5256 }}
+*{{cite journal   |vauthors=Lange C, Liehr T, Goen M, etal |title=New eukaryotic semaphorins with close homology to semaphorins of DNA viruses. |journal=Genomics |volume=51 |issue= 3 |pages= 340–50 |year= 1998 |pmid= 9721204 |doi= 10.1006/geno.1998.5256 }}
-*{{cite journal  | author=Yamada A, Kubo K, Takeshita T, ''et al.'' |title=Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4094-100 |year= 1999 |pmid= 10201933 |doi=  }}
+*{{cite journal   |vauthors=Yamada A, Kubo K, Takeshita T, etal |title=Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108. |journal=J. Immunol. |volume=162 |issue= 7 |pages= 4094–100 |year= 1999 |pmid= 10201933 |doi=  }}
-*{{cite journal  | author=Angelisová P, Drbal K, Cerný J, ''et al.'' |title=Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. |journal=Immunobiology |volume=200 |issue= 2 |pages= 234-45 |year= 1999 |pmid= 10416131 |doi=  }}
+*{{cite journal   |vauthors=Angelisová P, Drbal K, Cerný J, etal |title=Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. |journal=Immunobiology |volume=200 |issue= 2 |pages= 234–45 |year= 1999 |pmid= 10416131 |doi=  10.1016/s0171-2985(99)80073-4}}
-*{{cite journal  | author=Tamagnone L, Artigiani S, Chen H, ''et al.'' |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |journal=Cell |volume=99 |issue= 1 |pages= 71-80 |year= 1999 |pmid= 10520995 |doi=  }}
+*{{cite journal   |vauthors=Tamagnone L, Artigiani S, Chen H, etal |title=Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |journal=Cell |volume=99 |issue= 1 |pages= 71–80 |year= 1999 |pmid= 10520995 |doi=10.1016/S0092-8674(00)80063-X  }}
-*{{cite journal  | author=Mine T, Harada K, Matsumoto T, ''et al.'' |title=CDw108 expression during T-cell development. |journal=Tissue Antigens |volume=55 |issue= 5 |pages= 429-36 |year= 2000 |pmid= 10885563 |doi=  }}
+*{{cite journal   |vauthors=Mine T, Harada K, Matsumoto T, etal |title=CDw108 expression during T-cell development. |journal=Tissue Antigens |volume=55 |issue= 5 |pages= 429–36 |year= 2000 |pmid= 10885563 |doi=10.1034/j.1399-0039.2000.550505.x  }}
-*{{cite journal  | author=Holmes S, Downs AM, Fosberry A, ''et al.'' |title=Sema7A is a potent monocyte stimulator. |journal=Scand. J. Immunol. |volume=56 |issue= 3 |pages= 270-5 |year= 2002 |pmid= 12193228 |doi=  }}
+*{{cite journal   |vauthors=Holmes S, Downs AM, Fosberry A, etal |title=Sema7A is a potent monocyte stimulator. |journal=Scand. J. Immunol. |volume=56 |issue= 3 |pages= 270–5 |year= 2002 |pmid= 12193228 |doi=10.1046/j.1365-3083.2002.01129.x  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Maurin JC, Delorme G, Machuca-Gayet I, ''et al.'' |title=Odontoblast expression of semaphorin 7A during innervation of human dentin. |journal=Matrix Biol. |volume=24 |issue= 3 |pages= 232-8 |year= 2005 |pmid= 15907379 |doi= 10.1016/j.matbio.2005.03.005 }}
+*{{cite journal   |vauthors=Maurin JC, Delorme G, Machuca-Gayet I, etal |title=Odontoblast expression of semaphorin 7A during innervation of human dentin. |journal=Matrix Biol. |volume=24 |issue= 3 |pages= 232–8 |year= 2005 |pmid= 15907379 |doi= 10.1016/j.matbio.2005.03.005 }}
-*{{cite journal  | author=Hu Y, Malone JP, Fagan AM, ''et al.'' |title=Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. |journal=Mol. Cell Proteomics |volume=4 |issue= 12 |pages= 2000-9 |year= 2006 |pmid= 16199891 |doi= 10.1074/mcp.M500207-MCP200 }}
+*{{cite journal   |vauthors=Hu Y, Malone JP, Fagan AM, etal |title=Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid. |journal=Mol. Cell. Proteomics |volume=4 |issue= 12 |pages= 2000–9 |year= 2006 |pmid= 16199891 |doi= 10.1074/mcp.M500207-MCP200 }}
-*{{cite journal  | author=Koh JM, Oh B, Lee JY, ''et al.'' |title=Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. |journal=J. Hum. Genet. |volume=51 |issue= 2 |pages= 112-7 |year= 2006 |pmid= 16372136 |doi= 10.1007/s10038-005-0331-z }}
+*{{cite journal   |vauthors=Koh JM, Oh B, Lee JY, etal |title=Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women. |journal=J. Hum. Genet. |volume=51 |issue= 2 |pages= 112–7 |year= 2006 |pmid= 16372136 |doi= 10.1007/s10038-005-0331-z }}
 }}
 {{refend}}
@@ Line 86: / Line 48: @@
 ==External links==
 * {{MeshName|SEMA7A+protein,+human}}
+* [https://www.ncbi.nlm.nih.gov/projects/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=jmh John Milton Hagen blood group system] in the [[BGMUT]] blood group antigen gene mutation database
 {{NLM content}}
 {{Clusters of differentiation}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:Clusters of differentiation]]
-[[Category:Clusters of differentiation]]
-{{WH}}
+{{membrane-protein-stub}}
-{{WS}}

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

SEMA7A: Difference between revisions

Latest revision as of 06:06, 11 September 2017

Contents

Genetics

Molecular biology

Notes

See also

References

Further reading

External links

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