NCR1

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Natural cytotoxicity triggering receptor 1
File:PBB Protein NCR1 image.jpg
PDB rendering based on 1oll.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols NCR1 ; CD335; LY94; NK-p46; NKP46
External IDs Template:OMIM5 Template:MGI HomoloGene: 3551
RNA expression pattern
File:PBB GE NCR1 217088 s at tn.png
File:PBB GE NCR1 207860 at tn.png
File:PBB GE NCR1 217095 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Natural cytotoxicity triggering receptor 1, also known as NCR1, is a human gene.[1] NCR1 has also been designated as CD335 (cluster of differentiation 335).


References

  1. ↑ "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".

Further reading

  • Biassoni R, Cantoni C, Marras D; et al. (2004). "Human natural killer cell receptors: insights into their molecular function and structure". J. Cell. Mol. Med. 7 (4): 376–87. PMID 14754506.
  • Sivori S, Vitale M, Morelli L; et al. (1997). "p46, a novel natural killer cell-specific surface molecule that mediates cell activation". J. Exp. Med. 186 (7): 1129–36. PMID 9314561.
  • Vitale M, Bottino C, Sivori S; et al. (1998). "NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis". J. Exp. Med. 187 (12): 2065–72. PMID 9625766.
  • Pessino A, Sivori S, Bottino C; et al. (1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J. Exp. Med. 188 (5): 953–60. PMID 9730896.
  • Cantoni C, Bottino C, Vitale M; et al. (1999). "NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily". J. Exp. Med. 189 (5): 787–96. PMID 10049942.
  • Vankayalapati R, Wizel B, Weis SE; et al. (2002). "The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium". J. Immunol. 168 (7): 3451–7. PMID 11907104.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Augugliaro R, Parolini S, Castriconi R; et al. (2003). "Selective cross-talk among natural cytotoxicity receptors in human natural killer cells". Eur. J. Immunol. 33 (5): 1235–41. doi:10.1002/eji.200323896. PMID 12731048.
  • Ponassi M, Cantoni C, Biassoni R; et al. (2003). "Structure of the human NK cell triggering receptor NKp46 ectodomain". Biochem. Biophys. Res. Commun. 309 (2): 317–23. PMID 12951052.
  • Foster CE, Colonna M, Sun PD (2003). "Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors". J. Biol. Chem. 278 (46): 46081–6. doi:10.1074/jbc.M308491200. PMID 12960161.
  • Arnon TI, Achdout H, Lieberman N; et al. (2004). "The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46". Blood. 103 (2): 664–72. doi:10.1182/blood-2003-05-1716. PMID 14504081.
  • Marcenaro E, Augugliaro R, Falco M; et al. (2004). "CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity". Eur. J. Immunol. 33 (12): 3367–76. doi:10.1002/eji.200324425. PMID 14635045.
  • Carbone E, Neri P, Mesuraca M; et al. (2005). "HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells". Blood. 105 (1): 251–8. doi:10.1182/blood-2004-04-1422. PMID 15328155.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Mavoungou E, Bouyou-Akotet MK, Kremsner PG (2005). "Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30)". Clin. Exp. Immunol. 139 (2): 287–96. doi:10.1111/j.1365-2249.2004.02686.x. PMID 15654827.
  • Nowbakht P, Ionescu MC, Rohner A; et al. (2005). "Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias". Blood. 105 (9): 3615–22. doi:10.1182/blood-2004-07-2585. PMID 15657183.
  • Poggi A, Massaro AM, Negrini S; et al. (2005). "Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors". J. Immunol. 174 (5): 2653–60. PMID 15728472.
  • Zilka A, Landau G, Hershkovitz O; et al. (2006). "Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46". Biochemistry. 44 (44): 14477–85. doi:10.1021/bi051241s. PMID 16262248.
  • Hermann E, Alonso-Vega C, Berthe A; et al. (2006). "Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells". Pediatr. Res. 60 (1): 38–43. doi:10.1203/01.pdr.0000220335.05588.ea. PMID 16690951.

External links

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