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{{Infobox_gene}}
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'''Natural cytotoxicity triggering receptor 1''' is a [[protein]] that in humans is encoded by the ''NCR1'' [[gene]].<ref name="pmid9730896">{{cite journal |vauthors=Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A | title = Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity | journal = J Exp Med | volume = 188 | issue = 5 | pages = 953–60 |date=Sep 1998 | pmid = 9730896 | pmc =  3207313| doi =10.1084/jem.188.5.953 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9437| accessdate = }}</ref> NCR1 has also been designated as '''CD335''' ([[cluster of differentiation]] 335).
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{{GNF_Protein_box
| image = PBB_Protein_NCR1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oll.
| PDB = {{PDB2|1oll}}, {{PDB2|1p6f}}
| Name = Natural cytotoxicity triggering receptor 1
| HGNCid = 6731
| Symbol = NCR1
| AltSymbols =; CD335; LY94; NK-p46; NKP46
| OMIM = 604530
| ECnumber =
| Homologene = 3551
| MGIid = 1336212
  | GeneAtlas_image1 = PBB_GE_NCR1_217088_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCR1_207860_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCR1_217095_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005057 |text = receptor signaling protein activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016514 |text = SWI/SNF complex}}
| Process = {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030101 |text = natural killer cell activation}} {{GNF_GO|id=GO:0042269 |text = regulation of natural killer cell mediated cytotoxicity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9437
    | Hs_Ensembl = ENSG00000189430
    | Hs_RefseqProtein = NP_004820
    | Hs_RefseqmRNA = NM_004829
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 60109351
    | Hs_GenLoc_end = 60116153
    | Hs_Uniprot = O76036
    | Mm_EntrezGene = 17086
    | Mm_Ensembl = ENSMUSG00000062524
    | Mm_RefseqmRNA = NM_010746
    | Mm_RefseqProtein = NP_034876
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 3940811
    | Mm_GenLoc_end = 3948251
    | Mm_Uniprot = Q3T9W3
  }}
}}
'''Natural cytotoxicity triggering receptor 1''', also known as '''NCR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9437| accessdate = }}</ref> NCR1 has also been designated as '''CD335''' ([[cluster of differentiation]] 335).


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Biassoni R, Cantoni C, Marras D, ''et al.'' |title=Human natural killer cell receptors: insights into their molecular function and structure. |journal=J. Cell. Mol. Med. |volume=7 |issue= 4 |pages= 376-87 |year= 2004 |pmid= 14754506 |doi=  }}
*{{cite journal  | author=Biassoni R |title=Human natural killer cell receptors: insights into their molecular function and structure |journal=J. Cell. Mol. Med. |volume=7 |issue= 4 |pages= 376–87 |year= 2004 |pmid= 14754506 |doi=10.1111/j.1582-4934.2003.tb00240.x |name-list-format=vanc| author2=Cantoni C | author3=Marras D  | display-authors=3  | last4=Giron-Michel  | first4=J. | last5=Falco  | first5=Michela  | last6=Moretta  | first6=L.  | last7=Dimasi  | first7=N. }}
*{{cite journal | author=Sivori S, Vitale M, Morelli L, ''et al.'' |title=p46, a novel natural killer cell-specific surface molecule that mediates cell activation. |journal=J. Exp. Med. |volume=186 |issue= 7 |pages= 1129-36 |year= 1997 |pmid= 9314561 |doi=  }}
*{{cite journal  | author=Sivori S |title=p46, a Novel Natural Killer Cell–specific Surface Molecule That Mediates Cell Activation |journal=J. Exp. Med. |volume=186 |issue= 7 |pages= 1129–36 |year= 1997 |pmid= 9314561 |doi=10.1084/jem.186.7.1129 | pmc=2211712 |name-list-format=vanc| author2=Vitale M  | author3=Morelli L  | display-authors=3  | last4=Sanseverino  | first4=L  | last5=Augugliaro  | first5=R  | last6=Bottino  | first6=C  | last7=Moretta | first7=L  | last8=Moretta  | first8=A  }}
*{{cite journal  | author=Vitale M, Bottino C, Sivori S, ''et al.'' |title=NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2065-72 |year= 1998 |pmid= 9625766 |doi=  }}
*{{cite journal  | author=Vitale M |title=NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis |journal=J. Exp. Med. |volume=187 |issue= 12 |pages= 2065–72 |year= 1998 |pmid= 9625766 |doi=10.1084/jem.187.12.2065 | pmc=2212362 |name-list-format=vanc| author2=Bottino C  | author3=Sivori S  | display-authors=3  | last4=Sanseverino  | first4=L  | last5=Castriconi  | first5=R  | last6=Marcenaro  | first6=E | last7=Augugliaro  | first7=R  | last8=Moretta  | first8=L  | last9=Moretta  | first9=A  }}
*{{cite journal | author=Pessino A, Sivori S, Bottino C, ''et al.'' |title=Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. |journal=J. Exp. Med. |volume=188 |issue= 5 |pages= 953-60 |year= 1998 |pmid= 9730896 |doi=  }}
*{{cite journal  | author=Cantoni C |title=NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily |journal=J. Exp. Med. |volume=189 |issue= 5 |pages= 787–96 |year= 1999 |pmid= 10049942 |doi=10.1084/jem.189.5.787  | pmc=2192947 |name-list-format=vanc| author2=Bottino C | author3=Vitale M  | display-authors=3  | last4=Pessino  | first4=A  | last5=Augugliaro  | first5=R  | last6=Malaspina  | first6=A | last7=Parolini | first7=S  | last8=Moretta  | first8=L  | last9=Moretta  | first9=A  }}
*{{cite journal  | author=Cantoni C, Bottino C, Vitale M, ''et al.'' |title=NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. |journal=J. Exp. Med. |volume=189 |issue= 5 |pages= 787-96 |year= 1999 |pmid= 10049942 |doi=  }}
*{{cite journal  | author=Vankayalapati R |title=The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3451–7 |year= 2002 |pmid= 11907104 |doi= 10.4049/jimmunol.168.7.3451|name-list-format=vanc| author2=Wizel B | author3=Weis SE  | display-authors=3  | last4=Safi  | first4=H | last5=Lakey  | first5=DL  | last6=Mandelboim  | first6=O  | last7=Samten  | first7=B  | last8=Porgador  | first8=A  | last9=Barnes  | first9=PF  }}
*{{cite journal | author=Vankayalapati R, Wizel B, Weis SE, ''et al.'' |title=The NKp46 receptor contributes to NK cell lysis of mononuclear phagocytes infected with an intracellular bacterium. |journal=J. Immunol. |volume=168 |issue= 7 |pages= 3451-7 |year= 2002 |pmid= 11907104 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner | first7=L | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Augugliaro R |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235–41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896  |name-list-format=vanc| author2=Parolini S  | author3=Castriconi R  | display-authors=3  | last4=Marcenaro  | first4=Emanuela  | last5=Cantoni  | first5=Claudia  | last6=Nanni  | first6=Marina  | last7=Moretta  | first7=Lorenzo  | last8=Moretta  | first8=Alessandro  | last9=Bottino  | first9=Cristina }}
*{{cite journal  | author=Augugliaro R, Parolini S, Castriconi R, ''et al.'' |title=Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. |journal=Eur. J. Immunol. |volume=33 |issue= 5 |pages= 1235-41 |year= 2003 |pmid= 12731048 |doi= 10.1002/eji.200323896 }}
*{{cite journal  | author=Ponassi M |title=Structure of the human NK cell triggering receptor NKp46 ectodomain |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 2 |pages= 317–23 |year= 2003 |pmid= 12951052 |doi=10.1016/j.bbrc.2003.08.007  |name-list-format=vanc| author2=Cantoni C  | author3=Biassoni R  | display-authors=3  | last4=Conte  | first4=Romana  | last5=Spallarossa  | first5=Andrea  | last6=Pesce  | first6=Alessandra  | last7=Moretta  | first7=Alessandro  | last8=Moretta  | first8=Lorenzo  | last9=Bolognesi  | first9=Martino }}
*{{cite journal | author=Ponassi M, Cantoni C, Biassoni R, ''et al.'' |title=Structure of the human NK cell triggering receptor NKp46 ectodomain. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 2 |pages= 317-23 |year= 2003 |pmid= 12951052 |doi=  }}
*{{cite journal  |vauthors=Foster CE, Colonna M, Sun PD |title=Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 46081–6 |year= 2003 |pmid= 12960161 |doi= 10.1074/jbc.M308491200 }}
*{{cite journal | author=Foster CE, Colonna M, Sun PD |title=Crystal structure of the human natural killer (NK) cell activating receptor NKp46 reveals structural relationship to other leukocyte receptor complex immunoreceptors. |journal=J. Biol. Chem. |volume=278 |issue= 46 |pages= 46081-6 |year= 2003 |pmid= 12960161 |doi= 10.1074/jbc.M308491200 }}
*{{cite journal  | author=Arnon TI |title=The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46 |journal=Blood |volume=103 |issue= 2 |pages= 664–72 |year= 2004 |pmid= 14504081 |doi= 10.1182/blood-2003-05-1716  |name-list-format=vanc| author2=Achdout H  | author3=Lieberman N  | display-authors=3  | last4=Gazit  | first4=R  | last5=Gonen-Gross  | first5=T  | last6=Katz  | first6=G  | last7=Bar-Ilan  | first7=A  | last8=Bloushtain  | first8=N  | last9=Lev  | first9=M }}
*{{cite journal | author=Arnon TI, Achdout H, Lieberman N, ''et al.'' |title=The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. |journal=Blood |volume=103 |issue= 2 |pages= 664-72 |year= 2004 |pmid= 14504081 |doi= 10.1182/blood-2003-05-1716 }}
*{{cite journal  | author=Marcenaro E |title=CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity |journal=Eur. J. Immunol. |volume=33 |issue= 12 |pages= 3367–76 |year= 2004 |pmid= 14635045 |doi= 10.1002/eji.200324425  |name-list-format=vanc| author2=Augugliaro R  | author3=Falco M  | display-authors=3  | last4=Castriconi  | first4=Roberta  | last5=Parolini  | first5=Silvia  | last6=Sivori  | first6=Simona  | last7=Romeo  | first7=Elisa  | last8=Millo  | first8=Romano  | last9=Moretta  | first9=Lorenzo }}
*{{cite journal  | author=Marcenaro E, Augugliaro R, Falco M, ''et al.'' |title=CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity. |journal=Eur. J. Immunol. |volume=33 |issue= 12 |pages= 3367-76 |year= 2004 |pmid= 14635045 |doi= 10.1002/eji.200324425 }}
*{{cite journal  | author=Carbone E |title=HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells |journal=Blood |volume=105 |issue= 1 |pages= 251–8 |year= 2005 |pmid= 15328155 |doi= 10.1182/blood-2004-04-1422  |name-list-format=vanc| author2=Neri P  | author3=Mesuraca M  | display-authors=3  | last4=Fulciniti  | first4=MT  | last5=Otsuki  | first5=T  | last6=Pende  | first6=D  | last7=Groh  | first7=V  | last8=Spies  | first8=T  | last9=Pollio  | first9=G }}
*{{cite journal | author=Carbone E, Neri P, Mesuraca M, ''et al.'' |title=HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells. |journal=Blood |volume=105 |issue= 1 |pages= 251-8 |year= 2005 |pmid= 15328155 |doi= 10.1182/blood-2004-04-1422 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Mavoungou E, Bouyou-Akotet MK, Kremsner PG |title=Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30) |journal=Clin. Exp. Immunol. |volume=139 |issue= 2 |pages= 287–96 |year= 2005 |pmid= 15654827 |doi= 10.1111/j.1365-2249.2004.02686.x  | pmc=1809301 }}
*{{cite journal  | author=Mavoungou E, Bouyou-Akotet MK, Kremsner PG |title=Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30). |journal=Clin. Exp. Immunol. |volume=139 |issue= 2 |pages= 287-96 |year= 2005 |pmid= 15654827 |doi= 10.1111/j.1365-2249.2004.02686.x }}
*{{cite journal  | author=Nowbakht P |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias |journal=Blood |volume=105 |issue= 9 |pages= 3615–22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585  |name-list-format=vanc| author2=Ionescu MC  | author3=Rohner A  | display-authors=3  | last4=Kalberer  | first4=CP  | last5=Rossy  | first5=E  | last6=Mori  | first6=L  | last7=Cosman  | first7=D  | last8=De Libero  | first8=G  | last9=Wodnar-Filipowicz  | first9=A }}
*{{cite journal  | author=Nowbakht P, Ionescu MC, Rohner A, ''et al.'' |title=Ligands for natural killer cell-activating receptors are expressed upon the maturation of normal myelomonocytic cells but at low levels in acute myeloid leukemias. |journal=Blood |volume=105 |issue= 9 |pages= 3615-22 |year= 2005 |pmid= 15657183 |doi= 10.1182/blood-2004-07-2585 }}
*{{cite journal  | author=Poggi A |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653–60 |year= 2005 |pmid= 15728472 |doi=  10.4049/jimmunol.174.5.2653|name-list-format=vanc| author2=Massaro AM  | author3=Negrini S  | display-authors=3  | last4=Contini  | first4=P  | last5=Zocchi  | first5=MR  }}
*{{cite journal  | author=Poggi A, Massaro AM, Negrini S, ''et al.'' |title=Tumor-induced apoptosis of human IL-2-activated NK cells: role of natural cytotoxicity receptors. |journal=J. Immunol. |volume=174 |issue= 5 |pages= 2653-60 |year= 2005 |pmid= 15728472 |doi=  }}
*{{cite journal  | author=Zilka A |title=Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46 |journal=Biochemistry |volume=44 |issue= 44 |pages= 14477–85 |year= 2006 |pmid= 16262248 |doi= 10.1021/bi051241s  |name-list-format=vanc| author2=Landau G  | author3=Hershkovitz O  | display-authors=3  | last4=Bloushtain  | first4=Noga  | last5=Bar-Ilan  | first5=Ahuva  | last6=Benchetrit  | first6=Fabrice  | last7=Fima  | first7=Eyal  | last8=Van Kuppevelt  | first8=Toin H.  | last9=Gallagher  | first9=John T. }}
*{{cite journal  | author=Zilka A, Landau G, Hershkovitz O, ''et al.'' |title=Characterization of the heparin/heparan sulfate binding site of the natural cytotoxicity receptor NKp46. |journal=Biochemistry |volume=44 |issue= 44 |pages= 14477-85 |year= 2006 |pmid= 16262248 |doi= 10.1021/bi051241s }}
*{{cite journal  | author=Hermann E |title=Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells |journal=Pediatr. Res. |volume=60 |issue= 1 |pages= 38–43 |year= 2006 |pmid= 16690951 |doi= 10.1203/01.pdr.0000220335.05588.ea  |name-list-format=vanc| author2=Alonso-Vega C  | author3=Berthe A  | display-authors=3  | last4=Truyens  | first4=Carine  | last5=Flores  | first5=Amilcar  | last6=Cordova  | first6=Marisol  | last7=Moretta  | first7=Lorenzo  | last8=Torrico  | first8=Faustino  | last9=Braud  | first9=Veronique }}
*{{cite journal  | author=Hermann E, Alonso-Vega C, Berthe A, ''et al.'' |title=Human congenital infection with Trypanosoma cruzi induces phenotypic and functional modifications of cord blood NK cells. |journal=Pediatr. Res. |volume=60 |issue= 1 |pages= 38-43 |year= 2006 |pmid= 16690951 |doi= 10.1203/01.pdr.0000220335.05588.ea }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9437}}


==External links==
==External links==
* {{MeshName|NCR1+protein,+human}}
* {{MeshName|NCR1+protein,+human}}


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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{{DEFAULTSORT:Ncr1}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Human proteins]]

Latest revision as of 12:42, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Natural cytotoxicity triggering receptor 1 is a protein that in humans is encoded by the NCR1 gene.[1][2] NCR1 has also been designated as CD335 (cluster of differentiation 335).


References

  1. ↑ Pessino A, Sivori S, Bottino C, Malaspina A, Morelli L, Moretta L, Biassoni R, Moretta A (Sep 1998). "Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity". J Exp Med. 188 (5): 953–60. doi:10.1084/jem.188.5.953. PMC 3207313. PMID 9730896.
  2. ↑ "Entrez Gene: NCR1 natural cytotoxicity triggering receptor 1".

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=NCR1&oldid=1418859"