Leptin receptor
| Leptin receptor | |||||||||||
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| Identifiers | |||||||||||
| Symbols | LEPR ; CD295; OBR | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1731 | ||||||||||
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| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
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Leptin receptor, also known as LEPR, is a human gene. LEPR has also been designated as CD295 (cluster of differentiation 295).
Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM][1]
References
Further reading
- Heshka JT, Jones PJ (2001). "A role for dietary fat in leptin receptor, OB-Rb, function". Life Sci. 69 (9): 987–1003. PMID 11508653.
- Tartaglia LA, Dembski M, Weng X; et al. (1996). "Identification and expression cloning of a leptin receptor, OB-R". Cell. 83 (7): 1263–71. PMID 8548812.
- Chen H, Charlat O, Tartaglia LA; et al. (1996). "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice". Cell. 84 (3): 491–5. PMID 8608603.
- Cioffi JA, Shafer AW, Zupancic TJ; et al. (1996). "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction". Nat. Med. 2 (5): 585–9. PMID 8616721.
- Considine RV, Considine EL, Williams CJ; et al. (1996). "The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations". Diabetes. 45 (7): 992–4. PMID 8666155.
- Chung WK, Power-Kehoe L, Chua M, Leibel RL (1996). "Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human". Genome Res. 6 (5): 431–8. PMID 8743992.
- Bennett BD, Solar GP, Yuan JQ; et al. (1997). "A role for leptin and its cognate receptor in hematopoiesis". Curr. Biol. 6 (9): 1170–80. PMID 8805376.
- Winick JD, Stoffel M, Friedman JM (1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1". Genomics. 36 (1): 221–2. doi:10.1006/geno.1996.0455. PMID 8812446.
- Luoh SM, Di Marco F, Levin N; et al. (1997). "Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin". J. Mol. Endocrinol. 18 (1): 77–85. PMID 9061609.
- Echwald SM, Sørensen TD, Sørensen TI; et al. (1997). "Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity". Biochem. Biophys. Res. Commun. 233 (1): 248–52. doi:10.1006/bbrc.1997.6430. PMID 9144432.
- Thompson DB, Ravussin E, Bennett PH, Bogardus C (1997). "Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians". Hum. Mol. Genet. 6 (5): 675–9. PMID 9158141.
- Gotoda T, Manning BS, Goldstone AP; et al. (1997). "Leptin receptor gene variation and obesity: lack of association in a white British male population". Hum. Mol. Genet. 6 (6): 869–76. PMID 9175732.
- Bailleul B, Akerblom I, Strosberg AD (1997). "The leptin receptor promoter controls expression of a second distinct protein". Nucleic Acids Res. 25 (14): 2752–8. PMID 9207021.
- Chung WK, Power-Kehoe L, Chua M; et al. (1997). "Exonic and intronic sequence variation in the human leptin receptor gene (LEPR)". Diabetes. 46 (9): 1509–11. PMID 9287054.
- Bjørbaek C, Uotani S, da Silva B, Flier JS (1998). "Divergent signaling capacities of the long and short isoforms of the leptin receptor". J. Biol. Chem. 272 (51): 32686–95. PMID 9405487.
- Clément K, Vaisse C, Lahlou N; et al. (1998). "A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction". Nature. 392 (6674): 398–401. doi:10.1038/32911. PMID 9537324.
- Carpenter LR, Farruggella TJ, Symes A; et al. (1998). "Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6061–6. PMID 9600917.
- Kielar D, Clark JS, Ciechanowicz A; et al. (1998). "Leptin receptor isoforms expressed in human adipose tissue". Metab. Clin. Exp. 47 (7): 844–7. PMID 9667233.
- Haniu M, Arakawa T, Bures EJ; et al. (1998). "Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain". J. Biol. Chem. 273 (44): 28691–9. PMID 9786864.
- Haft CR, de la Luz Sierra M, Barr VA; et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol. Cell. Biol. 18 (12): 7278–87. PMID 9819414.
External links
- LEPR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.