LILRB2

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
File:PBB Protein LILRB2 image.jpg PDB rendering based on 2dyp.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 2dyp​, 2gw5​
Identifiers
Symbols	LILRB2 ; CD85D; ILT4; LIR-2; LIR2; MIR-10; MIR10
External IDs	Template:OMIM5 HomoloGene: 81741
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2, also known as LILRB2, is a human gene.

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.

See also

• Cluster of differentiation

Further reading

• Suciu-Foca N, Cortesini R (2007). "Central role of ILT3 in the T suppressor cell cascade". Cell. Immunol. 248 (1): 59–67. doi:10.1016/j.cellimm.2007.01.013. PMID 17923119.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Samaridis J, Colonna M (1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur. J. Immunol. 27 (3): 660–5. PMID 9079806.
• Cella M, Döhring C, Samaridis J; et al. (1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J. Exp. Med. 185 (10): 1743–51. PMID 9151699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wagtmann N, Rojo S, Eichler E; et al. (1997). "A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors". Curr. Biol. 7 (8): 615–8. PMID 9259559.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colonna M, Navarro F, Bellón T; et al. (1997). "A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells". J. Exp. Med. 186 (11): 1809–18. PMID 9382880.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colonna M, Samaridis J, Cella M; et al. (1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. 160 (7): 3096–100. PMID 9531263.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Borges L, Hsu ML, Fanger N; et al. (1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J. Immunol. 159 (11): 5192–6. PMID 9548455.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fanger NA, Cosman D, Peterson L; et al. (1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. 28 (11): 3423–34. PMID 9842885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allan DS, Colonna M, Lanier LL; et al. (1999). "Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells". J. Exp. Med. 189 (7): 1149–56. PMID 10190906.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lepin EJ, Bastin JM, Allan DS; et al. (2001). "Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors". Eur. J. Immunol. 30 (12): 3552–61. PMID 11169396.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Young NT, Canavez F, Uhrberg M; et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. PMID 11491530.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chang CC, Ciubotariu R, Manavalan JS; et al. (2002). "Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4". Nat. Immunol. 3 (3): 237–43. doi:10.1038/ni760. PMID 11875462.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Willcox BE, Thomas LM, Chapman TL; et al. (2003). "Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18". BMC Struct. Biol. 2: 6. PMID 12390682.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shiroishi M, Tsumoto K, Amano K; et al. (2003). "Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8856–61. doi:10.1073/pnas.1431057100. PMID 12853576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakajima H, Asai A, Okada A; et al. (2004). "Transcriptional regulation of ILT family receptors". J. Immunol. 171 (12): 6611–20. PMID 14662864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Papanikolaou NA, Vasilescu ER, Suciu-Foca N (2005). "Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4". Hum. Immunol. 65 (7): 700–5. doi:10.1016/j.humimm.2004.04.003. PMID 15301858.CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

External links

• LILRB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.