LILRB2: Difference between revisions

Jump to navigation Jump to search
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Bibcode Bot
m (Adding 0 arxiv eprint(s), 2 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Use dmy dates|date=April 2013}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Leukocyte immunoglobulin-like receptor subfamily B member 2''' is a [[protein]] that in humans is encoded by the ''LILRB2'' [[gene]].<ref name="pmid9151699">{{cite journal |vauthors=Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M | title = A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing | journal = J Exp Med | volume = 185 | issue = 10 | pages = 1743–51 |date=Jun 1997 | pmid = 9151699 | pmc = 2196312 | doi =10.1084/jem.185.10.1743  }}</ref><ref name="pmid9079806">{{cite journal |vauthors=Samaridis J, Colonna M | title = Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways | journal = Eur J Immunol | volume = 27 | issue = 3 | pages = 660–5 |date=Apr 1997 | pmid = 9079806 | pmc =  | doi =10.1002/eji.1830270313 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10288| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_LILRB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dyp.
| PDB = {{PDB2|2dyp}}, {{PDB2|2gw5}}
| Name = Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
| HGNCid = 6606
| Symbol = LILRB2
| AltSymbols =; CD85D; ILT4; LIR-2; LIR2; MIR-10; MIR10
| OMIM = 604815
| ECnumber = 
| Homologene = 81741
| MGIid = 
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006968 |text = cellular defense response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10288
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001074447
    | Hs_RefseqmRNA = NM_001080978
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2''', also known as '''LILRB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10288| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10288| accessdate = }}</ref>
| summary_text = This gene is a member of the [[leukocyte immunoglobulin-like receptor]] (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
}}
}}
==Interactions==
LILRB2 has been shown to [[Protein-protein interaction|interact]] with [[PTPN6]].<ref name=pmid9842885>{{cite journal |last=Fanger |first=N A |authorlink= |author2=Cosman D |author3=Peterson L |author4=Braddy S C |author5=Maliszewski C R |author6=Borges L  |date=Nov 1998 |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes |journal=Eur. J. Immunol. |volume=28 |issue=11 |pages=3423–34 |publisher= |location = GERMANY| issn = 0014-2980| pmid = 9842885 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2 }}</ref><ref name=pmid9531263>{{cite journal |last=Colonna |first=M |authorlink= |author2=Samaridis J |author3=Cella M |author4=Angman L |author5=Allen R L |author6=O'Callaghan C A |author7=Dunbar R |author8=Ogg G S |author9=Cerundolo V |author10=Rolink A  |date=Apr 1998 |title=Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules |journal=J. Immunol. |volume=160 |issue=7 |pages=3096–100 |publisher= |location = UNITED STATES| issn = 0022-1767| pmid = 9531263 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==
Line 57: Line 16:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
Line 63: Line 22:
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Suciu-Foca N, Cortesini R |title=Central role of ILT3 in the T suppressor cell cascade. |journal=Cell. Immunol. |volume=248 |issue= 1 |pages= 59-67 |year= 2007 |pmid= 17923119 |doi= 10.1016/j.cellimm.2007.01.013 }}
*{{cite journal  |vauthors=Suciu-Foca N, Cortesini R |title=Central role of ILT3 in the T suppressor cell cascade. |journal=Cell. Immunol. |volume=248 |issue= 1 |pages= 59–67 |year= 2007 |pmid= 17923119 |doi= 10.1016/j.cellimm.2007.01.013 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Samaridis J, Colonna M |title=Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways. |journal=Eur. J. Immunol. |volume=27 |issue= 3 |pages= 660-5 |year= 1997 |pmid= 9079806 |doi=  }}
*{{cite journal   |vauthors=Wagtmann N, Rojo S, Eichler E, etal |title=A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 615–8 |year= 1997 |pmid= 9259559 |doi=10.1016/S0960-9822(06)00263-6 }}
*{{cite journal | author=Cella M, Döhring C, Samaridis J, ''et al.'' |title=A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. |journal=J. Exp. Med. |volume=185 |issue= 10 |pages= 1743-51 |year= 1997 |pmid= 9151699 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Wagtmann N, Rojo S, Eichler E, ''et al.'' |title=A new human gene complex encoding the killer cell inhibitory receptors and related monocyte/macrophage receptors. |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 615-8 |year= 1997 |pmid= 9259559 |doi= }}
*{{cite journal   |vauthors=Colonna M, Navarro F, Bellón T, etal |title=A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells |journal=J. Exp. Med. |volume=186 |issue= 11 |pages= 1809–18 |year= 1997 |pmid= 9382880 |doi=10.1084/jem.186.11.1809  | pmc=2199153  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Colonna M, Samaridis J, Cella M, etal |title=Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules |journal=J. Immunol. |volume=160 |issue= 7 |pages= 3096–100 |year= 1998 |pmid= 9531263 |doi=  }}
*{{cite journal | author=Colonna M, Navarro F, Bellón T, ''et al.'' |title=A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. |journal=J. Exp. Med. |volume=186 |issue= 11 |pages= 1809-18 |year= 1997 |pmid= 9382880 |doi=  }}
*{{cite journal   |vauthors=Borges L, Hsu ML, Fanger N, etal |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192–6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal | author=Colonna M, Samaridis J, Cella M, ''et al.'' |title=Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. |journal=J. Immunol. |volume=160 |issue= 7 |pages= 3096-100 |year= 1998 |pmid= 9531263 |doi= }}
*{{cite journal   |vauthors=Fanger NA, Cosman D, Peterson L, etal |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes |journal=Eur. J. Immunol. |volume=28 |issue= 11 |pages= 3423–34 |year= 1998 |pmid= 9842885 |doi=10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2  }}
*{{cite journal | author=Borges L, Hsu ML, Fanger N, ''et al.'' |title=A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules. |journal=J. Immunol. |volume=159 |issue= 11 |pages= 5192-6 |year= 1998 |pmid= 9548455 |doi=  }}
*{{cite journal   |vauthors=Allan DS, Colonna M, Lanier LL, etal |title=Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells |journal=J. Exp. Med. |volume=189 |issue= 7 |pages= 1149–56 |year= 1999 |pmid= 10190906 |doi=10.1084/jem.189.7.1149  | pmc=2193000 }}
*{{cite journal | author=Fanger NA, Cosman D, Peterson L, ''et al.'' |title=The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes. |journal=Eur. J. Immunol. |volume=28 |issue= 11 |pages= 3423-34 |year= 1998 |pmid= 9842885 |doi= }}
*{{cite journal   |vauthors=Lepin EJ, Bastin JM, Allan DS, etal |title=Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors |journal=Eur. J. Immunol. |volume=30 |issue= 12 |pages= 3552–61 |year= 2001 |pmid= 11169396 |doi=10.1002/1521-4141(200012)30:12<3552::AID-IMMU3552>3.0.CO;2-L  }}
*{{cite journal | author=Allan DS, Colonna M, Lanier LL, ''et al.'' |title=Tetrameric complexes of human histocompatibility leukocyte antigen (HLA)-G bind to peripheral blood myelomonocytic cells. |journal=J. Exp. Med. |volume=189 |issue= 7 |pages= 1149-56 |year= 1999 |pmid= 10190906 |doi=  }}
*{{cite journal   |vauthors=Young NT, Canavez F, Uhrberg M, etal |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=10.1007/s002510100332 }}
*{{cite journal | author=Lepin EJ, Bastin JM, Allan DS, ''et al.'' |title=Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors. |journal=Eur. J. Immunol. |volume=30 |issue= 12 |pages= 3552-61 |year= 2001 |pmid= 11169396 |doi= }}
*{{cite journal   |vauthors=Chang CC, Ciubotariu R, Manavalan JS, etal |title=Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4 |journal=Nat. Immunol. |volume=3 |issue= 3 |pages= 237–43 |year= 2002 |pmid= 11875462 |doi= 10.1038/ni760 }}
*{{cite journal | author=Young NT, Canavez F, Uhrberg M, ''et al.'' |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270-8 |year= 2001 |pmid= 11491530 |doi= }}
*{{cite journal   |vauthors=Willcox BE, Thomas LM, Chapman TL, etal |title=Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18 |journal=BMC Struct. Biol. |volume=2|pages= 6 |year= 2003 |pmid= 12390682 |doi=10.1186/1472-6807-2-6  | pmc=130215  }}
*{{cite journal  | author=Chang CC, Ciubotariu R, Manavalan JS, ''et al.'' |title=Tolerization of dendritic cells by T(S) cells: the crucial role of inhibitory receptors ILT3 and ILT4. |journal=Nat. Immunol. |volume=3 |issue= 3 |pages= 237-43 |year= 2002 |pmid= 11875462 |doi= 10.1038/ni760 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Willcox BE, Thomas LM, Chapman TL, ''et al.'' |title=Crystal structure of LIR-2 (ILT4) at 1.8 A: differences from LIR-1 (ILT2) in regions implicated in the binding of the Human Cytomegalovirus class I MHC homolog UL18. |journal=BMC Struct. Biol. |volume=2 |issue= |pages= 6 |year= 2003 |pmid= 12390682 |doi=  }}
*{{cite journal   |vauthors=Shiroishi M, Tsumoto K, Amano K, etal |title=Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8856–61 |year= 2003 |pmid= 12853576 |doi= 10.1073/pnas.1431057100 | pmc=166403 |bibcode=2003PNAS..100.8856S }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Nakajima H, Asai A, Okada A, etal |title=Transcriptional regulation of ILT family receptors |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6611–20 |year= 2004 |pmid= 14662864 |doi= 10.4049/jimmunol.171.12.6611}}
*{{cite journal  | author=Shiroishi M, Tsumoto K, Amano K, ''et al.'' |title=Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 15 |pages= 8856-61 |year= 2003 |pmid= 12853576 |doi= 10.1073/pnas.1431057100 }}
*{{cite journal  |vauthors=Papanikolaou NA, Vasilescu ER, Suciu-Foca N |title=Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4 |journal=Hum. Immunol. |volume=65 |issue= 7 |pages= 700–5 |year= 2005 |pmid= 15301858 |doi= 10.1016/j.humimm.2004.04.003 }}
*{{cite journal | author=Nakajima H, Asai A, Okada A, ''et al.'' |title=Transcriptional regulation of ILT family receptors. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6611-20 |year= 2004 |pmid= 14662864 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Papanikolaou NA, Vasilescu ER, Suciu-Foca N |title=Novel single nucleotide polymorphisms in the human immune inhibitory immunoglobulin-like T cell receptor type 4. |journal=Hum. Immunol. |volume=65 |issue= 7 |pages= 700-5 |year= 2005 |pmid= 15301858 |doi= 10.1016/j.humimm.2004.04.003 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10288}}


==External links==
==External links==
* {{MeshName|LILRB2+protein,+human}}
* {{MeshName|LILRB2+protein,+human}}
* {{UCSC genome browser|LILRB2}}
* {{UCSC gene details|LILRB2}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
[[Category:Immunoglobulin superfamily]]
 
 
{{immunology-stub}}
{{membrane-protein-stub}}

Latest revision as of 18:35, 24 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Leukocyte immunoglobulin-like receptor subfamily B member 2 is a protein that in humans is encoded by the LILRB2 gene.[1][2][3]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

LILRB2 has been shown to interact with PTPN6.[4][5]

See also

References

  1. Cella M, Dohring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M (Jun 1997). "A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing". J Exp Med. 185 (10): 1743–51. doi:10.1084/jem.185.10.1743. PMC 2196312. PMID 9151699.
  2. Samaridis J, Colonna M (Apr 1997). "Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways". Eur J Immunol. 27 (3): 660–5. doi:10.1002/eji.1830270313. PMID 9079806.
  3. 3.0 3.1 "Entrez Gene: LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2".
  4. Fanger, N A; Cosman D; Peterson L; Braddy S C; Maliszewski C R; Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". Eur. J. Immunol. GERMANY. 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. ISSN 0014-2980. PMID 9842885.
  5. Colonna, M; Samaridis J; Cella M; Angman L; Allen R L; O'Callaghan C A; Dunbar R; Ogg G S; Cerundolo V; Rolink A (Apr 1998). "Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules". J. Immunol. UNITED STATES. 160 (7): 3096–100. ISSN 0022-1767. PMID 9531263.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.