ITGA6: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Use dmy dates|date=July 2013}}
{{PBB_Controls
{{Infobox_gene}}
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'''Integrin alpha-6''' is a [[protein]] that in humans is encoded by the ''ITGA6'' [[gene]].
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Integrin, alpha 6
| HGNCid = 6142
| Symbol = ITGA6
| AltSymbols =; CD49f; ITGA6B; VLA-6
| OMIM = 147556
| ECnumber = 
| Homologene = 20091
| MGIid = 96605
| GeneAtlas_image1 = PBB_GE_ITGA6_201656_at_tn.png
| GeneAtlas_image2 = PBB_GE_ITGA6_215177_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0008305 |text = integrin complex}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}}
| Process = {{GNF_GO|id=GO:0007044 |text = cell-substrate junction assembly}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007160 |text = cell-matrix adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0042475 |text = odontogenesis (sensu Vertebrata)}} {{GNF_GO|id=GO:0046847 |text = filopodium formation}} {{GNF_GO|id=GO:0050900 |text = leukocyte migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3655
    | Hs_Ensembl = ENSG00000091409
    | Hs_RefseqProtein = NP_000201
    | Hs_RefseqmRNA = NM_000210
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 173000616
    | Hs_GenLoc_end = 173079256
    | Hs_Uniprot = P23229
    | Mm_EntrezGene = 16403
    | Mm_Ensembl = ENSMUSG00000027111
    | Mm_RefseqmRNA = NM_008397
    | Mm_RefseqProtein = NP_032423
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 71587779
    | Mm_GenLoc_end = 71657597
    | Mm_Uniprot = Q3TWK2
  }}
}}
'''Integrin, alpha 6''', also known as '''ITGA6''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ITGA6 integrin, alpha 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655| accessdate = }}</ref>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: ITGA6 integrin, alpha 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3655| accessdate = }}</ref>
 
}}
ITGA6 has been shown to [[Protein-protein interaction|interact]] with [[TSPAN4]]<ref name=pmid9360996>{{cite journal | vauthors = Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME | title = NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins | journal = The Journal of Biological Chemistry | volume = 272 | issue = 46 | pages = 29181–9 | date = November 1997 | pmid = 9360996 | doi = 10.1074/jbc.272.46.29181 }}</ref> and [[GIPC1]].<ref name=pmid11479315>{{cite journal | vauthors = Tani TT, Mercurio AM | title = PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B | journal = The Journal of Biological Chemistry | volume = 276 | issue = 39 | pages = 36535–42 | date = September 2001 | pmid = 11479315 | doi = 10.1074/jbc.M105785200 }}</ref>
==See also==
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]
* [[Integrin]]s
* [[Integrin]]s


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lipscomb EA, Mercurio AM | title = Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression | journal = Cancer Metastasis Reviews | volume = 24 | issue = 3 | pages = 413–23 | date = September 2005 | pmid = 16258729 | doi = 10.1007/s10555-005-5133-4 }}
| citations =
*{{cite journal | author=Lipscomb EA, Mercurio AM |title=Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression. |journal=Cancer Metastasis Rev. |volume=24 |issue= 3 |pages= 413-23 |year= 2006 |pmid= 16258729 |doi= 10.1007/s10555-005-5133-4 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CD49f+Antigen}}
* {{MeshName|CD49f+Antigen}}
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=3655 ITGA6] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]


{{membrane-protein-stub}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Cell adhesion proteins]]
{{Integrins}}
 
{{DEFAULTSORT:Itga6}}
[[Category:Integrins]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Latest revision as of 00:39, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[1]

Interactions

ITGA6 has been shown to interact with TSPAN4[2] and GIPC1.[3]

See also

References

  1. ↑ "Entrez Gene: ITGA6 integrin, alpha 6".
  2. ↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  3. ↑ Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Further reading

  • Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=ITGA6&oldid=1412133"