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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''CD226''' ('''C'''luster of '''D'''ifferentiation 226), '''PTA1''' (outdated term, 'platelet and T cell activation antigen 1')<ref name='Fuchs-2006'>{{cite journal | vauthors = Fuchs A, Colonna M | title = The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance | journal = Seminars in Cancer Biology | volume = 16 | issue = 5 | pages = 359–66 | date = October 2006 | pmid = 16904340 | doi = 10.1016/j.semcancer.2006.07.002 }}<!--|accessdate=2010-04-17--></ref> or '''DNAM-1''' ([[DNAX|'''D'''NAX]] '''A'''ccessory '''M'''olecule-'''1''')<ref name='Fuchs-2006' /> is a [[protein]] that in humans is encoded by the ''CD226'' [[gene]] which is located on chromosome 18q22.3.<ref name="entrez">{{cite web | title = Entrez Gene: CD226 CD226 molecule| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10666| accessdate = }}</ref>
| update_page = yes
__NOTOC__
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure and function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = CD226 molecule
| HGNCid = 16961
| Symbol = CD226
| AltSymbols =; DNAM-1; DNAM1; PTA1; TLiSA1
| OMIM = 605397
| ECnumber = 
| Homologene = 4787
| MGIid = 3039602
| GeneAtlas_image1 = PBB_GE_CD226_207315_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001816 |text = cytokine production}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10666
    | Hs_Ensembl = ENSG00000150637
    | Hs_RefseqProtein = NP_006557
    | Hs_RefseqmRNA = NM_006566
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 65681175
    | Hs_GenLoc_end = 65775140
    | Hs_Uniprot = Q15762
    | Mm_EntrezGene = 225825
    | Mm_Ensembl = ENSMUSG00000034028
    | Mm_RefseqmRNA = NM_001039148
    | Mm_RefseqProtein = NP_001034237
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 89331620
    | Mm_GenLoc_end = 89404520
    | Mm_Uniprot = Q5DW69
  }}
}}
'''CD226''' ('''C'''luster of '''D'''ifferentiation 226) is a human [[protein]] encoded by the {{gene|CD226}} [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CD226 CD226 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10666| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
CD226 is a ~65 kDa glycoprotein expressed on the surface of [[natural killer cell]]s, [[platelet]]s, [[monocyte]]s and a subset of [[T cell]]s. It is a member of the [[immunoglobulin superfamily]] containing 2 Ig-like domains of the [[immunoglobulin V-set domain|V-set]].<ref name="pmid12913096"/>
{{PBB_Summary
| section_title =
| summary_text = CD226 is a ~65 kDa glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set and is encoded by a gene on human chromosome 18q22.3. CD226 mediates cellular adhesion to other cells bearing an unidentified ligand and cross-linking CD226 with antibodies causes cellular activation.<ref name="entrez">{{cite web | title = Entrez Gene: CD226 CD226 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10666| accessdate = }}</ref>
}}


==See also==
CD226 mediates cellular adhesion to other cells bearing its ligands, [[PVRL2|CD112]] and [[CD155]],<ref name="pmid12913096">{{cite journal | vauthors = Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A | title = Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule | journal = The Journal of Experimental Medicine | volume = 198 | issue = 4 | pages = 557–67 | date = August 2003 | pmid = 12913096 | pmc = 2194180 | doi = 10.1084/jem.20030788 }}</ref><ref name="pmid15039383">{{cite journal | vauthors = Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A | title = Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112) | journal = [[International Immunology]] | volume = 16 | issue = 4 | pages = 533–8 | date = April 2004 | pmid = 15039383 | doi = 10.1093/intimm/dxh059 }}</ref> and cross-linking CD226 with antibodies causes cellular activation.<ref name="entrez"/>
 
== See also ==
* [[Cluster of differentiation]]
* [[Cluster of differentiation]]
* [[Nectin]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH | title = DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes | journal = Immunity | volume = 4 | issue = 6 | pages = 573–81 | date = June 1996 | pmid = 8673704 | doi = 10.1016/S1074-7613(00)70060-4 }}
| citations =
* {{cite journal | vauthors = Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A | title = Physical and functional association of LFA-1 with DNAM-1 adhesion molecule | journal = Immunity | volume = 11 | issue = 5 | pages = 615–23 | date = November 1999 | pmid = 10591186 | doi = 10.1016/S1074-7613(00)80136-3 }}
*{{cite journal | author=Shibuya A, Campbell D, Hannum C, ''et al.'' |title=DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes. |journal=Immunity |volume=4 |issue= 6 |pages= 573-81 |year= 1996 |pmid= 8673704 |doi= }}
* {{cite journal | vauthors = Kojima H, Kanada H, Shimizu S, Kasama E, Shibuya K, Nakauchi H, Nagasawa T, Shibuya A | title = CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36748–53 | date = September 2003 | pmid = 12847109 | doi = 10.1074/jbc.M300702200 }}
*{{cite journal | author=Shibuya K, Lanier LL, Phillips JH, ''et al.'' |title=Physical and functional association of LFA-1 with DNAM-1 adhesion molecule. |journal=Immunity |volume=11 |issue= 5 |pages= 615-23 |year= 2000 |pmid= 10591186 |doi= }}
* {{cite journal | vauthors = Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, Miyamoto A, Onodera M, Sumida T, Nakauchi H, Miyoshi H, Shibuya A | title = CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation | journal = The Journal of Experimental Medicine | volume = 198 | issue = 12 | pages = 1829–39 | date = December 2003 | pmid = 14676297 | pmc = 2194159 | doi = 10.1084/jem.20030958 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Reymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, Farnarier C, Cantoni C, Bottino C, Moretta A, Dubreuil P, Lopez M | title = DNAM-1 and PVR regulate monocyte migration through endothelial junctions | journal = The Journal of Experimental Medicine | volume = 199 | issue = 10 | pages = 1331–41 | date = May 2004 | pmid = 15136589 | pmc = 2211807 | doi = 10.1084/jem.20032206 }}
*{{cite journal | author=Kojima H, Kanada H, Shimizu S, ''et al.'' |title=CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36748-53 |year= 2003 |pmid= 12847109 |doi= 10.1074/jbc.M300702200 }}
* {{cite journal | vauthors = Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF | title = The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large | journal = The Journal of Biological Chemistry | volume = 279 | issue = 32 | pages = 33816–28 | date = August 2004 | pmid = 15138281 | doi = 10.1074/jbc.M401040200 }}
*{{cite journal | author=Bottino C, Castriconi R, Pende D, ''et al.'' |title=Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule. |journal=J. Exp. Med. |volume=198 |issue= 4 |pages= 557-67 |year= 2003 |pmid= 12913096 |doi= 10.1084/jem.20030788 }}
* {{cite journal | vauthors = Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L | title = Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112) | journal = Blood | volume = 105 | issue = 5 | pages = 2066–73 | date = March 2005 | pmid = 15536144 | doi = 10.1182/blood-2004-09-3548 }}
*{{cite journal | author=Shibuya K, Shirakawa J, Kameyama T, ''et al.'' |title=CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation. |journal=J. Exp. Med. |volume=198 |issue= 12 |pages= 1829-39 |year= 2004 |pmid= 14676297 |doi= 10.1084/jem.20030958 }}
* {{cite journal | vauthors = Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A | title = PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis | journal = Molecular Immunology | volume = 42 | issue = 4 | pages = 463–9 | date = February 2005 | pmid = 15607800 | doi = 10.1016/j.molimm.2004.07.028 }}
*{{cite journal | author=Tahara-Hanaoka S, Shibuya K, Onoda Y, ''et al.'' |title=Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). |journal=Int. Immunol. |volume=16 |issue= 4 |pages= 533-8 |year= 2005 |pmid= 15039383 |doi= }}
* {{cite journal | vauthors = Tao D, Shangwu L, Qun W, Yan L, Wei J, Junyan L, Feili G, Boquan J, Jinquan T | title = CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus | journal = Journal of Immunology | volume = 174 | issue = 3 | pages = 1281–90 | date = February 2005 | pmid = 15661884 | doi = 10.4049/jimmunol.174.3.1281 }}
*{{cite journal | author=Reymond N, Imbert AM, Devilard E, ''et al.'' |title=DNAM-1 and PVR regulate monocyte migration through endothelial junctions. |journal=J. Exp. Med. |volume=199 |issue= 10 |pages= 1331-41 |year= 2004 |pmid= 15136589 |doi= 10.1084/jem.20032206 }}
* {{cite journal | vauthors = Ma D, Sun Y, Lin D, Wang H, Dai B, Zhang X, Ouyang W, Jian J, Jia W, Xu X, Jin B | title = CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization | journal = European Journal of Haematology | volume = 74 | issue = 3 | pages = 228–40 | date = March 2005 | pmid = 15693793 | doi = 10.1111/j.1600-0609.2004.00345.x }}
*{{cite journal | author=Ralston KJ, Hird SL, Zhang X, ''et al.'' |title=The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33816-28 |year= 2004 |pmid= 15138281 |doi= 10.1074/jbc.M401040200 }}
* {{cite journal | vauthors = Storojeva I, Boulay JL, Ballabeni P, Buess M, Terracciano L, Laffer U, Mild G, Herrmann R, Rochlitz C | title = Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer | journal = Oncology | volume = 68 | issue = 2-3 | pages = 246–55 | year = 2005 | pmid = 16015041 | doi = 10.1159/000086781 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F | title = Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process | journal = The Journal of Biological Chemistry | volume = 281 | issue = 37 | pages = 27190–6 | date = September 2006 | pmid = 16831868 | doi = 10.1074/jbc.M602359200 }}
*{{cite journal | author=Pende D, Spaggiari GM, Marcenaro S, ''et al.'' |title=Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112). |journal=Blood |volume=105 |issue= 5 |pages= 2066-73 |year= 2005 |pmid= 15536144 |doi= 10.1182/blood-2004-09-3548 }}
* {{cite journal | vauthors = Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ | title = Identification and characterization of the CD226 gene promoter | journal = The Journal of Biological Chemistry | volume = 281 | issue = 39 | pages = 28731–6 | date = September 2006 | pmid = 16887814 | doi = 10.1074/jbc.M601786200 }}
*{{cite journal | author=Pende D, Bottino C, Castriconi R, ''et al.'' |title=PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. |journal=Mol. Immunol. |volume=42 |issue= 4 |pages= 463-9 |year= 2005 |pmid= 15607800 |doi= 10.1016/j.molimm.2004.07.028 }}
* {{cite journal | vauthors = Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H | title = Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients | journal = Viral Immunology | volume = 19 | issue = 3 | pages = 576–81 | year = 2006 | pmid = 16987076 | doi = 10.1089/vim.2006.19.576 }}
*{{cite journal | author=Tao D, Shangwu L, Qun W, ''et al.'' |title=CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus. |journal=J. Immunol. |volume=174 |issue= 3 |pages= 1281-90 |year= 2005 |pmid= 15661884 |doi= }}
* {{cite journal | vauthors = El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP | title = The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells | journal = Cancer Research | volume = 67 | issue = 18 | pages = 8444–9 | date = September 2007 | pmid = 17875681 | doi = 10.1158/0008-5472.CAN-06-4230 }}
*{{cite journal | author=Ma D, Sun Y, Lin D, ''et al.'' |title=CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization. |journal=Eur. J. Haematol. |volume=74 |issue= 3 |pages= 228-40 |year= 2005 |pmid= 15693793 |doi= 10.1111/j.1600-0609.2004.00345.x }}
*{{cite journal  | author=Storojeva I, Boulay JL, Ballabeni P, ''et al.'' |title=Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer. |journal=Oncology |volume=68 |issue= 2-3 |pages= 246-55 |year= 2005 |pmid= 16015041 |doi= 10.1159/000086781 }}
*{{cite journal  | author=Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F |title=Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. |journal=J. Biol. Chem. |volume=281 |issue= 37 |pages= 27190-6 |year= 2006 |pmid= 16831868 |doi= 10.1074/jbc.M602359200 }}
*{{cite journal  | author=Jian JL, Zhu CS, Xu ZW, ''et al.'' |title=Identification and characterization of the CD226 gene promoter. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28731-6 |year= 2006 |pmid= 16887814 |doi= 10.1074/jbc.M601786200 }}
*{{cite journal  | author=Ye X, Zhang Z, Jiang Y, ''et al.'' |title=Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients. |journal=Viral Immunol. |volume=19 |issue= 3 |pages= 576-81 |year= 2006 |pmid= 16987076 |doi= 10.1089/vim.2006.19.576 }}
*{{cite journal  | author=El-Sherbiny YM, Meade JL, Holmes TD, ''et al.'' |title=The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells. |journal=Cancer Res. |volume=67 |issue= 18 |pages= 8444-9 |year= 2007 |pmid= 17875681 |doi= 10.1158/0008-5472.CAN-06-4230 }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|CD226+protein,+human}}
* {{MeshName|CD226+protein,+human}}
* {{UCSC gene info|CD226}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 09:03, 9 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1')[1] or DNAM-1 (DNAX Accessory Molecule-1)[1] is a protein that in humans is encoded by the CD226 gene which is located on chromosome 18q22.3.[2]


Structure and function

CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.[3]

CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155,[3][4] and cross-linking CD226 with antibodies causes cellular activation.[2]

See also

References

  1. ↑ 1.0 1.1 Fuchs A, Colonna M (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Seminars in Cancer Biology. 16 (5): 359–66. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  2. ↑ 2.0 2.1 "Entrez Gene: CD226 CD226 molecule".
  3. ↑ 3.0 3.1 Bottino C, Castriconi R, Pende D, Rivera P, Nanni M, Carnemolla B, Cantoni C, Grassi J, Marcenaro S, Reymond N, Vitale M, Moretta L, Lopez M, Moretta A (August 2003). "Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule". The Journal of Experimental Medicine. 198 (4): 557–67. doi:10.1084/jem.20030788. PMC 2194180. PMID 12913096.
  4. ↑ Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A (April 2004). "Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112)". International Immunology. 16 (4): 533–8. doi:10.1093/intimm/dxh059. PMID 15039383.

Further reading

  • Shibuya A, Campbell D, Hannum C, Yssel H, Franz-Bacon K, McClanahan T, Kitamura T, Nicholl J, Sutherland GR, Lanier LL, Phillips JH (June 1996). "DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes". Immunity. 4 (6): 573–81. doi:10.1016/S1074-7613(00)70060-4. PMID 8673704.
  • Shibuya K, Lanier LL, Phillips JH, Ochs HD, Shimizu K, Nakayama E, Nakauchi H, Shibuya A (November 1999). "Physical and functional association of LFA-1 with DNAM-1 adhesion molecule". Immunity. 11 (5): 615–23. doi:10.1016/S1074-7613(00)80136-3. PMID 10591186.
  • Kojima H, Kanada H, Shimizu S, Kasama E, Shibuya K, Nakauchi H, Nagasawa T, Shibuya A (September 2003). "CD226 mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells". The Journal of Biological Chemistry. 278 (38): 36748–53. doi:10.1074/jbc.M300702200. PMID 12847109.
  • Shibuya K, Shirakawa J, Kameyama T, Honda S, Tahara-Hanaoka S, Miyamoto A, Onodera M, Sumida T, Nakauchi H, Miyoshi H, Shibuya A (December 2003). "CD226 (DNAM-1) is involved in lymphocyte function-associated antigen 1 costimulatory signal for naive T cell differentiation and proliferation". The Journal of Experimental Medicine. 198 (12): 1829–39. doi:10.1084/jem.20030958. PMC 2194159. PMID 14676297.
  • Reymond N, Imbert AM, Devilard E, Fabre S, Chabannon C, Xerri L, Farnarier C, Cantoni C, Bottino C, Moretta A, Dubreuil P, Lopez M (May 2004). "DNAM-1 and PVR regulate monocyte migration through endothelial junctions". The Journal of Experimental Medicine. 199 (10): 1331–41. doi:10.1084/jem.20032206. PMC 2211807. PMID 15136589.
  • Ralston KJ, Hird SL, Zhang X, Scott JL, Jin B, Thorne RF, Berndt MC, Boyd AW, Burns GF (August 2004). "The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large". The Journal of Biological Chemistry. 279 (32): 33816–28. doi:10.1074/jbc.M401040200. PMID 15138281.
  • Pende D, Spaggiari GM, Marcenaro S, Martini S, Rivera P, Capobianco A, Falco M, Lanino E, Pierri I, Zambello R, Bacigalupo A, Mingari MC, Moretta A, Moretta L (March 2005). "Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)". Blood. 105 (5): 2066–73. doi:10.1182/blood-2004-09-3548. PMID 15536144.
  • Pende D, Bottino C, Castriconi R, Cantoni C, Marcenaro S, Rivera P, Spaggiari GM, Dondero A, Carnemolla B, Reymond N, Mingari MC, Lopez M, Moretta L, Moretta A (February 2005). "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis". Molecular Immunology. 42 (4): 463–9. doi:10.1016/j.molimm.2004.07.028. PMID 15607800.
  • Tao D, Shangwu L, Qun W, Yan L, Wei J, Junyan L, Feili G, Boquan J, Jinquan T (February 2005). "CD226 expression deficiency causes high sensitivity to apoptosis in NK T cells from patients with systemic lupus erythematosus". Journal of Immunology. 174 (3): 1281–90. doi:10.4049/jimmunol.174.3.1281. PMID 15661884.
  • Ma D, Sun Y, Lin D, Wang H, Dai B, Zhang X, Ouyang W, Jian J, Jia W, Xu X, Jin B (March 2005). "CD226 is expressed on the megakaryocytic lineage from hematopoietic stem cells/progenitor cells and involved in its polyploidization". European Journal of Haematology. 74 (3): 228–40. doi:10.1111/j.1600-0609.2004.00345.x. PMID 15693793.
  • Storojeva I, Boulay JL, Ballabeni P, Buess M, Terracciano L, Laffer U, Mild G, Herrmann R, Rochlitz C (2005). "Prognostic and predictive relevance of DNAM-1, SOCS6 and CADH-7 genes on chromosome 18q in colorectal cancer". Oncology. 68 (2–3): 246–55. doi:10.1159/000086781. PMID 16015041.
  • Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (September 2006). "Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process". The Journal of Biological Chemistry. 281 (37): 27190–6. doi:10.1074/jbc.M602359200. PMID 16831868.
  • Jian JL, Zhu CS, Xu ZW, Ouyang WM, Ma DC, Zhang Y, Chen LJ, Yang AG, Jin BQ (September 2006). "Identification and characterization of the CD226 gene promoter". The Journal of Biological Chemistry. 281 (39): 28731–6. doi:10.1074/jbc.M601786200. PMID 16887814.
  • Ye X, Zhang Z, Jiang Y, Han X, Wang Y, Zhang M, Liu J, Geng W, Dai D, Shi W, Shang H (2006). "Expression of human CD226 on T cells and natural killer cells and of soluble CD226 in plasma of HIV-1-infected Chinese patients". Viral Immunology. 19 (3): 576–81. doi:10.1089/vim.2006.19.576. PMID 16987076.
  • El-Sherbiny YM, Meade JL, Holmes TD, McGonagle D, Mackie SL, Morgan AW, Cook G, Feyler S, Richards SJ, Davies FE, Morgan GJ, Cook GP (September 2007). "The requirement for DNAM-1, NKG2D, and NKp46 in the natural killer cell-mediated killing of myeloma cells". Cancer Research. 67 (18): 8444–9. doi:10.1158/0008-5472.CAN-06-4230. PMID 17875681.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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