Chlorphenoxamine: Difference between revisions

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{{drugbox
{{Drugbox
| IUPAC_name       = 2-[1-(4-chlorophenyl)-1-phenyl-ethoxy]-<br>''N'',''N''-dimethyl-ethanamine
| Verifiedfields = changed
| image             = Chlorphenoxamine.svg
| Watchedfields = changed
| CAS_number        = 77-38-3
| verifiedrevid = 447811372
| CAS_supplemental  = {{CAS|562-09-4}} ([[hydrochloride]])
| IUPAC_name = {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine
| ATC_prefix        = D04
| image = Chlorphenoxamine.svg
| ATC_suffix        = AA34
 
| ATC_supplemental  = {{ATC|R06|AA06}} {{ATC|R06|AA56}}
<!--Clinical data-->
| PubChem          = 6475
| tradename =
| DrugBank          =
| Drugs.com = {{drugs.com|international|chlorphenoxamine}}
| C = 18 | H = 22 | Cl = 1 | N = 1 | O = 1
| pregnancy_category =   
| molecular_weight  = 303.826 g/mol
| legal_status =   
| bioavailability  = Well absorbed
| protein_bound    =
| metabolism        = Likely [[liver|hepatic]]
| elimination_half-life =
| excretion        = [[Kidney|Renal]]
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category=   
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          =  <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US          =  <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      =
| routes_of_administration = Oral, topical
| routes_of_administration = Oral, topical
<!--Pharmacokinetic data-->
| bioavailability = Well absorbed
| protein_bound = 
| metabolism = Likely [[liver|hepatic]]
| elimination_half-life = 
| excretion = [[Kidney|Renal]]
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 77-38-3
| CAS_supplemental = {{CAS|562-09-4}}
| ATC_prefix = D04
| ATC_suffix = AA34
| ATC_supplemental =  {{ATC|R06|AA06}}
| PubChem = 6475
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB09007
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 6230
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL = 2110774
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3UVD77BP8R
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07198
<!--Chemical data-->
| C=18 | H=22 | Cl=1 | N=1 | O=1
| molecular_weight = 303.826 g/mol
| smiles = Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C
| InChI = 1/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3
| InChIKey = KKHPNPMTPORSQE-UHFFFAOYAK
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = KKHPNPMTPORSQE-UHFFFAOYSA-N
}}
}}
'''Chlorphenoxamine''' is an [[antipruritic]].


{{pharmacology-stub}}
'''Chlorphenoxamine''' ('''Phenoxene''') is an [[antihistamine]] and [[anticholinergic]] used as an [[antipruritic]]<ref>{{cite pmid|13967113}}</ref> and [[antiparkinsonian]]<ref>{{cite pmid|13779077}}</ref> agent. It is an analog of [[diphenhydramine]].<ref>H. Arnold, N. Brock, E. Kuhas, and D. Lorenz, Arzneimittel Forsch., 4, 189 (1954).</ref>
 
== References ==
{{Reflist}}
 
 
{{Antipruritics}}
{{Antipruritics}}
{{Antiparkinsonian}}
{{Antihistamines}}
{{Antihistamines}}
{{Cholinergics}}
{{Histaminergics}}
[[Category:H1 receptor antagonists]]
[[Category:H1 receptor antagonists]]
{{WikiDoc Help Menu}}
[[Category:Organochlorides]]
[[Category:Ethers]]
[[Category:Amines]]
 
 
{{respiratory-system-drug-stub}}
{{dermatologic-drug-stub}}
{{nervous-system-drug-stub}}

Revision as of 20:11, 10 April 2015

Chlorphenoxamine
File:Chlorphenoxamine.svg
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, topical
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
MetabolismLikely hepatic
ExcretionRenal
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC18H22ClNO
Molar mass303.826 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic[1] and antiparkinsonian[2] agent. It is an analog of diphenhydramine.[3]

References

  1. ↑ PMID 13967113 (PMID 13967113)
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  2. ↑ PMID 13779077 (PMID 13779077)
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  3. ↑ H. Arnold, N. Brock, E. Kuhas, and D. Lorenz, Arzneimittel Forsch., 4, 189 (1954).


Template:Antipruritics Template:Antiparkinsonian


Template:Respiratory-system-drug-stub Template:Dermatologic-drug-stub Template:Nervous-system-drug-stub

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