Triprolidine

Jump to: navigation, search
Triprolidine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.

Overview

Triprolidine is a antihistamine that is FDA approved for the treatment of symptoms due to hay fever (allergic rhinitis) or other upper respiratory allergies, runny nose, sneezing, itching of the nose or throat and itchy, watery eyes. Common adverse reactions include xerostomia, sedation, nasal mucosa dry, pharyngeal dryness, thick bronchial sputum.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Dosage Triprolidine.png

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Triprolidine in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Triprolidine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Dosage Triprolidine.png

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Triprolidine in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Triprolidine in pediatric patients.

Contraindications

There is limited information regarding Triprolidine Contraindications in the drug label.

Warnings

Do not exceed recommended dosage

Ask a doctor before use if you have:

Ask a doctor before use if you are taking sedatives or tranquilizers

When using this product

  • excitability may occur, especially in children
  • may cause drowsiness
  • alcohol, sedatives and tranquilizers may increase the drowsiness effect
  • avoid alcoholic beverages
  • use caution when driving a motor vehicle or operating machinery

Stop use and ask a doctor if new symptoms occur
If pregnant or breast-feeding, ask a health professional before use.
Keep out of the reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Triprolidine Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Triprolidine Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Triprolidine Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Triprolidine in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Triprolidine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Triprolidine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Triprolidine in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Triprolidine in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Triprolidine in geriatric settings.

Gender

There is no FDA guidance on the use of Triprolidine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Triprolidine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Triprolidine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Triprolidine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Triprolidine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Triprolidine in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Triprolidine Administration in the drug label.

Monitoring

There is limited information regarding Triprolidine Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Triprolidine and IV administrations.

Overdosage

There is limited information regarding Triprolidine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

Triprolidine Structure.png
Triprolidine
Systematic (IUPAC) name
2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-yl-
prop-1-enyl]pyridine
Identifiers
CAS number 486-12-4
ATC code R06AX07
PubChem 5282443
DrugBank DB00427
Chemical data
Formula C19H22N2 
Mol. mass 278.391 g/mol
SMILES eMolecules & PubChem
Physical data
Melt. point 60 °C (140 °F)
Solubility in water 500 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability 4% oral
Protein binding 90%
Metabolism Hepatic (CYP2D6)
Half life 4-6 hours
Excretion Renal
Therapeutic considerations
Pregnancy cat.

C (US)

Legal status

OTC (US)

Routes Oral

Mechanism of Action

There is limited information regarding Triprolidine Mechanism of Action in the drug label.

Structure

There is limited information regarding Triprolidine Structure in the drug label.

Pharmacodynamics

There is limited information regarding Triprolidine Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Triprolidine Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Triprolidine Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Triprolidine Clinical Studies in the drug label.

How Supplied

There is limited information regarding Triprolidine How Supplied in the drug label.

Storage

There is limited information regarding Triprolidine Storage in the drug label.

Images

Drug Images

Package and Label Display Panel

Triprolidine Appearance.png
Triprolidine Package1.png
Triprolidine Package2.png

Patient Counseling Information

There is limited information regarding Triprolidine Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Triprolidine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

There is limited information regarding Triprolidine Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.


Linked-in.jpg