Mequitazine

Mequitazine

Gene therapy
Clinical data
Trade names	Primalan
AHFS/Drugs.com	International Drug Names
ATC code	R06AD07 (WHO)
Physiological data
Legal status
Pharmacokinetic data
Identifiers
IUPAC name 10-(4-azabicyclo[2.2.2] oct-7-ylmethyl) phenothiazine
CAS Number	29216-28-2 Y
PubChem Template:Abbreviation	4066
DrugBank	DB01071 N
ChemSpider	3926 N
UNII	Y463242LY2
KEGG	D01324 Y
Chemical and physical data
Formula	C20H22N2S
Molar mass	322.468 g/mol
Template:XmarkY (what is this?)  (verify)

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mequitazine (trade name Primalan) is an antihistamine and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

Contraindications

Severe liver disease; premature infants or full-term neonates .

Special precautions

Pregnancy, lactation; severe CardioVascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.

Adverse drug reactions

CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.

Drug Interactions

Enhanced effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation reported with spiramycin.

See also

• Phenothiazine