Roxatidine

Roxatidine acetate

Clinical data
Routes of administration	Oral
ATC code	A02BA06 (WHO)
Pharmacokinetic data
Bioavailability	80–90%
Protein binding	5–7%
Metabolism	Hepatic deacetylation Minor involvement of CYP2D6 and CYP2A6
Elimination half-life	5–7 hours
Excretion	Renal
Identifiers
IUPAC name 2-oxo-2-(3-[3-(piperidin-1-ylmethyl)phenoxy]propylamino)ethyl acetate
CAS Number	78628-28-1 N
PubChem CID	5105
DrugBank	DB08806 Y
ChemSpider	4926 Y
UNII	IV9VHT3YUM
KEGG	D08495 Y
ChEMBL	ChEMBL46102 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C19H28N2O4
Molar mass	348.437 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(OCC(=O)NCCCOc1cc(ccc1)CN2CCCCC2)C
InChI InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23) Y Key:SMTZFNFIKUPEJC-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Experimental / Informatics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Roxatidine acetate is a specific and competitive histamine H₂ receptor antagonist drug that is used to treat gastric ulcers, Zollinger–Ellison syndrome, erosive esophagitis, gastro-oesophageal reflux disease, and gastritis.

Pharmacodynamic studies showed that 150 mg of roxatidine acetate were optimal in suppressing gastric acid secretion, and that a single bedtime dose of 150 mg was more effective than a dose of 75 mg twice daily in terms of inhibiting nocturnal acid secretion.

It is available in countries including China, Japan, Korea, Germany, Italy, the Netherlands, Greece and South Africa.

References

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