CCR4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''C-C chemokine receptor type 4''' is a [[protein]] that in humans is encoded by the ''CCR4'' [[gene]].<ref name="pmid7642634">{{cite journal | vauthors = Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN | title = Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line | journal = J Biol Chem | volume = 270 | issue = 33 | pages = 19495–500 |date=Sep 1995 | pmid = 7642634 | pmc =  | doi =10.1074/jbc.270.33.19495 }}</ref><ref name="pmid8884276">{{cite journal | vauthors = Samson M, Soularue P, Vassart G, Parmentier M | title = The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3 | journal = Genomics | volume = 36 | issue = 3 | pages = 522–6 |date=Feb 1997 | pmid = 8884276 | pmc =  | doi = 10.1006/geno.1996.0498 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCR4 chemokine (C-C motif) receptor 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1233| accessdate = }}</ref> CCR4 has also recently been designated '''CD194''' ([[cluster of differentiation]] 194).
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene belongs to the [[G protein-coupled receptor]] family. It is a receptor for the following [[chemokine#CC chemokines|CC chemokines]]:
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Chemokine (C-C motif) receptor 4
| HGNCid = 1605
| Symbol = CCR4
| AltSymbols =; CC-CKR-4; CKR4; CMKBR4; ChemR13; HGCN:14099; K5-5; MGC88293; k5-5, ChemR13, CD194
| OMIM = 604836
| ECnumber = 
| Homologene = 21135
| MGIid = 107824
| GeneAtlas_image1 = PBB_GE_CCR4_208376_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004945 |text = angiotensin type II receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007204 |text = elevation of cytosolic calcium ion concentration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1233
    | Hs_Ensembl = ENSG00000183813
    | Hs_RefseqProtein = NP_005499
    | Hs_RefseqmRNA = NM_005508
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 32968070
    | Hs_GenLoc_end = 32972840
    | Hs_Uniprot = P51679
    | Mm_EntrezGene = 12773
    | Mm_Ensembl = ENSMUSG00000047898
    | Mm_RefseqmRNA = NM_009916
    | Mm_RefseqProtein = NP_034046
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 114339014
    | Mm_GenLoc_end = 114345242
    | Mm_Uniprot = Q14A03
  }}
}}
'''Chemokine (C-C motif) receptor 4''', also known as '''CCR4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCR4 chemokine (C-C motif) receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1233| accessdate = }}</ref>


CCR4 has also recently been designated '''CD194''' ([[cluster of differentiation]] 194).
* [[CCL2]] (MCP-1)
* [[CCL4]] (MIP-1)
* [[CCL5]] (RANTES)
* [[CCL17]] (TARC)<ref name="pmid9169480">{{cite journal | vauthors = Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O | title = The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4 | journal = J. Biol. Chem. | volume = 272 | issue = 23 | pages = 15036–42 |date=June 1997 | pmid = 9169480 | doi = 10.1074/jbc.272.23.15036 }}</ref>
* [[CCL22]] (Macrophage-derived chemokine)<ref name="pmid9430724">{{cite journal | vauthors = Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW | title = Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4 | journal = J. Biol. Chem. | volume = 273 | issue = 3 | pages = 1764–8 |date=January 1998 | pmid = 9430724 | doi = 10.1074/jbc.273.3.1764 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Chemokine]]s are a group of small structurally related proteins that regulate cell trafficking of various types of [[white blood cell|leukocyte]]s. The chemokines also play fundamental roles in the development, homeostasis, and function of the [[immune system]], and they have effects on cells of the [[central nervous system]] as well as on [[endothelium|endothelial]] cells involved in [[angiogenesis]] or [[angiostasis]].<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==Clinical significance==
| summary_text = The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.<ref name="entrez">{{cite web | title = Entrez Gene: CCR4 chemokine (C-C motif) receptor 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1233| accessdate = }}</ref>
CCR4 is often expressed on leukemic cells in [[cutaneous T-cell lymphoma]] (CTCL).<ref name=FDA-mog-PR>[https://www.healio.com/hematology-oncology/lymphoma/news/online/%7B10b49c5e-c6d6-4c43-8b7c-630617559fb2%7D/fda-grants-priority-review-to-mogamulizumab-for-cutaneous-t-cell-lymphoma ''FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma'' Nov 2017]</ref>
}}
 
===As a drug target===
[[Mogamulizumab]] is a humanised [[monoclonal antibody]] targeted at CCR4 and is an [[investigational drug]] for CTCL.<ref name=FDA-mog-PR/>


==References==
==References==
{{reflist|2}}
{{Reflist|2}}
==Further reading==
 
{{refbegin | 2}}
==External links==
{{PBB_Further_reading
* {{UCSC gene info|CCR4}}
| citations =  
* {{MeshName|CCR4+receptor}}
*{{cite journal  | author=Yoshie O |title=Expression of CCR4 in adult T-cell leukemia. |journal=Leuk. Lymphoma |volume=46 |issue= 2 |pages= 185-90 |year= 2005 |pmid= 15621800 |doi= 10.1080/10428190400007607 }}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1288 | title = Chemokine Receptors: CCR4  | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
*{{cite journal  | author=Power CA, Meyer A, Nemeth K, ''et al.'' |title=Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19495-500 |year= 1995 |pmid= 7642634 |doi=  }}
 
*{{cite journal  | author=Hoogewerf A, Black D, Proudfoot AE, ''et al.'' |title=Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. |journal=Biochem. Biophys. Res. Commun. |volume=218 |issue= 1 |pages= 337-43 |year= 1996 |pmid= 8573157 |doi=  }}
*{{cite journal  | author=Samson M, Soularue P, Vassart G, Parmentier M |title=The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. |journal=Genomics |volume=36 |issue= 3 |pages= 522-6 |year= 1997 |pmid= 8884276 |doi= 10.1006/geno.1996.0498 }}
*{{cite journal  | author=Imai T, Baba M, Nishimura M, ''et al.'' |title=The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 15036-42 |year= 1997 |pmid= 9169480 |doi=  }}
*{{cite journal  | author=Imai T, Chantry D, Raport CJ, ''et al.'' |title=Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1764-8 |year= 1998 |pmid= 9430724 |doi=  }}
*{{cite journal  | author=Struyf S, Proost P, Sozzani S, ''et al.'' |title=Enhanced anti-HIV-1 activity and altered chemotactic potency of NH2-terminally processed macrophage-derived chemokine (MDC) imply an additional MDC receptor. |journal=J. Immunol. |volume=161 |issue= 6 |pages= 2672-5 |year= 1998 |pmid= 9743322 |doi=  }}
*{{cite journal  | author=Proost P, Struyf S, Schols D, ''et al.'' |title=Truncation of macrophage-derived chemokine by CD26/ dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 3988-93 |year= 1999 |pmid= 9933589 |doi=  }}
*{{cite journal  | author=Marchese A, Sawzdargo M, Nguyen T, ''et al.'' |title=Discovery of three novel orphan G-protein-coupled receptors. |journal=Genomics |volume=56 |issue= 1 |pages= 12-21 |year= 1999 |pmid= 10036181 |doi= 10.1006/geno.1998.5655 }}
*{{cite journal  | author=Campbell JJ, Haraldsen G, Pan J, ''et al.'' |title=The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. |journal=Nature |volume=400 |issue= 6746 |pages= 776-80 |year= 1999 |pmid= 10466728 |doi= 10.1038/23495 }}
*{{cite journal  | author=Inngjerdingen M, Damaj B, Maghazachi AA |title=Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. |journal=J. Immunol. |volume=164 |issue= 8 |pages= 4048-54 |year= 2000 |pmid= 10754297 |doi=  }}
*{{cite journal  | author=Kato H, Tsuchiya N, Izumi S, ''et al.'' |title=New variations of human CC-chemokine receptors CCR3 and CCR4. |journal=Genes Immun. |volume=1 |issue= 2 |pages= 97-104 |year= 2001 |pmid= 11196669 |doi= 10.1038/sj.gene.6363638 }}
*{{cite journal  | author=Yoshie O, Fujisawa R, Nakayama T, ''et al.'' |title=Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. |journal=Blood |volume=99 |issue= 5 |pages= 1505-11 |year= 2002 |pmid= 11861261 |doi=  }}
*{{cite journal  | author=Kim CH, Johnston B, Butcher EC |title=Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. |journal=Blood |volume=100 |issue= 1 |pages= 11-6 |year= 2002 |pmid= 12070001 |doi= 10.1182/blood-2001-12-0196 }}
*{{cite journal  | author=Juremalm M, Olsson N, Nilsson G |title=Selective CCL5/RANTES-induced mast cell migration through interactions with chemokine receptors CCR1 and CCR4. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 3 |pages= 480-5 |year= 2002 |pmid= 12270118 |doi=  }}
*{{cite journal  | author=Soler D, Humphreys TL, Spinola SM, Campbell JJ |title=CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. |journal=Blood |volume=101 |issue= 5 |pages= 1677-82 |year= 2003 |pmid= 12406880 |doi= 10.1182/blood-2002-07-2348 }}
*{{cite journal | author=Agrawal L, Vanhorn-Ali Z, Alkhatib G |title=Multiple determinants are involved in HIV coreceptor use as demonstrated by CCR4/CCL22 interaction in peripheral blood mononuclear cells (PBMCs). |journal=J. Leukoc. Biol. |volume=72 |issue= 5 |pages= 1063-74 |year= 2002 |pmid= 12429730 |doi= }}
*{{cite journal  | author=Uchida T, Suto H, Ra C, ''et al.'' |title=Preferential expression of T(h)2-type chemokine and its receptor in atopic dermatitis. |journal=Int. Immunol. |volume=14 |issue= 12 |pages= 1431-8 |year= 2003 |pmid= 12456591 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ferenczi K, Fuhlbrigge RC, Pinkus J, ''et al.'' |title=Increased CCR4 expression in cutaneous T cell lymphoma. |journal=J. Invest. Dermatol. |volume=119 |issue= 6 |pages= 1405-10 |year= 2003 |pmid= 12485447 |doi= 10.1046/j.1523-1747.2002.19610.x }}
}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
{{Chemokine receptors}}
{{Chemokine receptors}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Chemokine receptor modulators}}


[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 02:14, 30 November 2017

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Orthologs
SpeciesHumanMouse
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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

C-C chemokine receptor type 4 is a protein that in humans is encoded by the CCR4 gene.[1][2][3] CCR4 has also recently been designated CD194 (cluster of differentiation 194).

The protein encoded by this gene belongs to the G protein-coupled receptor family. It is a receptor for the following CC chemokines:

Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis.[3]

Clinical significance

CCR4 is often expressed on leukemic cells in cutaneous T-cell lymphoma (CTCL).[6]

As a drug target

Mogamulizumab is a humanised monoclonal antibody targeted at CCR4 and is an investigational drug for CTCL.[6]

References

  1. ↑ Power CA, Meyer A, Nemeth K, Bacon KB, Hoogewerf AJ, Proudfoot AE, Wells TN (Sep 1995). "Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line". J Biol Chem. 270 (33): 19495–500. doi:10.1074/jbc.270.33.19495. PMID 7642634.
  2. ↑ Samson M, Soularue P, Vassart G, Parmentier M (Feb 1997). "The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3". Genomics. 36 (3): 522–6. doi:10.1006/geno.1996.0498. PMID 8884276.
  3. ↑ 3.0 3.1 "Entrez Gene: CCR4 chemokine (C-C motif) receptor 4".
  4. ↑ Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S, Yoshie O (June 1997). "The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4". J. Biol. Chem. 272 (23): 15036–42. doi:10.1074/jbc.272.23.15036. PMID 9169480.
  5. ↑ Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW (January 1998). "Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4". J. Biol. Chem. 273 (3): 1764–8. doi:10.1074/jbc.273.3.1764. PMID 9430724.
  6. ↑ 6.0 6.1 FDA grants priority review to mogamulizumab for cutaneous T-cell lymphoma Nov 2017

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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