CCL19
| chemokine (C-C motif) ligand 19
| |
| Identifiers | |
| Symbol | CCL19 |
| Alt. Symbols | SCYA19, ELC, MIP-3b, exodus-3, CKb11 |
| Entrez | 6363 |
| HUGO | 10617 |
| OMIM | 602227 |
| RefSeq | NM_006274 |
| UniProt | Q99731 |
| Other data | |
| Locus | Chr. 9 p13 |
Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen.[1] The gene for CCL19 is located on human chromosome 9.[2]. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7.[1] It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells,[3][4] CCR7+ Effector-memory T-Cells [5]
References
- ↑ 1.0 1.1 Yoshida et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-13809, 1997.
- ↑ Rossi et al. Identification through bioinformatics of two new macrophage proinflammatory human chemokines. J. Immun. 158: 1033-1036, 1997.
- ↑ Robbiani et al,. The leukotriene C4 transporter MRP1 regulates CCL19 (MIP-3-beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell 103: 757-768, 2000.
- ↑ Reif et al. Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position. Nature 416: 94-99, 2002.
- ↑ Bromley et al,. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into lympaphatics. Nature Immunology 6: 895-901, 2005
Cytokines: chemokines | |
|---|---|
| CCL | CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28 |
| CXCL | CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17 |
| CX3CL | CX3CL1 |
| XCL | XCL1 - XCL2 |
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