Hormone receptor
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A hormone receptor is a receptor protein on the surface of a cell or in its interior that binds to a specific hormone. The hormone causes many changes to take place in the cell.
Binding of hormones to hormone receptors often trigger the start of a biophysical signal that can lead to further signal transduction pathways, or trigger the activation or inhibition of genes.[1]
Types of Hormone Receptors
- Peptide hormone receptors are often transmembrane proteins. They are also called G-protein-coupled receptors, sensory receptors or ionotropic receptors. These receptors generally function via intracellular second messengers, including cyclic AMP (cAMP), inositol 1,4,5-trisphosphate (IP3) and the calcium (Ca2+)-calmodulin system.
- Steroid hormone receptors and related receptors are generally soluble proteins that function through gene activation. Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The receptors themselves are zinc-finger proteins.[2] These receptors include those for glucocorticoids, estrogens, androgens, thyroid hormone (T3), calcitriol (the active form of vitamin D, and the retinoids (vitamin A).
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
