CCL26
| chemokine (C-C motif) ligand 26
| |
| Identifiers | |
| Symbol | CCL26 |
| Alt. Symbols | SCYA26, MIP-4alpha, eotaxin-3, IMAC, MIP-4a, TSC-1 |
| Entrez | 10344 |
| HUGO | 10625 |
| OMIM | 604697 |
| PDB | 1G2T |
| RefSeq | NM_006072 |
| UniProt | Q9Y258 |
| Other data | |
| Locus | Chr. 7 q11.2 |
Chemokine (C-C motif) ligand 26 (CCL26) is a small cytokine belonging to the CC chemokine family that is also called Eotaxin-3, Macrophage inflammatory protein 4-alpha (MIP-4-alpha), Thymic stroma chemokine-1 (TSC-1), and IMAC. It is expressed by several tissues including heart, lung and ovary, and in endothelial cells that have been stimulated with the cytokine interleukin 4.[1][2] CCL26 is chemotactic for eosinophils and basophils and elicits its effects by binding to the cell surface chemokine receptor CCR3.[3] This gene for chemokine is located on human chromosome 7.[4]
References
- ↑ Shinkai et al. A novel human CC chemokine, eotaxin-3, which is expressed in IL-4-stimulated vascular endothelial cells, exhibits potent activity toward eosinophils. J. Immunol. 163:1602-1610, 1999.
- ↑ Guo et al. Molecular cloning and characterization of a novel human CC chemokine, SCYA26. Genomics 58:313-317, 1999.
- ↑ Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
- ↑ Hillier et al. The DNA sequence of human chromosome 7. Nature 424:157-164, 2003.
Cytokines: chemokines | |
|---|---|
| CCL | CCL1 - CCL2 - CCL3 - CCL4 - CCL5 - CCL6 - CCL7 - CCL8 - CCL9 - CCL10 - CCL11 - CCL12 - CCL13 - CCL14 - CCL15 - CCL16 - CCL17 - CCL18 - CCL19 - CCL20 - CCL21 - CCL22 - CCL23 - CCL24 - CCL25 - CCL26 - CCL27 - CCL28 |
| CXCL | CXCL1 - CXCL2 - CXCL3 - CXCL4 - CXCL5 - CXCL6 - CXCL7 - CXCL8 - CXCL9 - CXCL10 - CXCL11 - CXCL12 - CXCL13 - CXCL14 - CXCL15 - CXCL16 - CXCL17 |
| CX3CL | CX3CL1 |
| XCL | XCL1 - XCL2 |
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