IL17RB

Interleukin 17 receptor B
Identifiers
Symbol(s)	IL17RB; CRL4; EVI27; IL17BR; IL17RH1; MGC5245
External IDs	OMIM: 605458 MGI: 1355292 Homologene: 10287
Gene ontology Molecular Function: • receptor activity • interleukin receptor activity Cellular Component: • integral to plasma membrane • membrane Biological Process: • regulation of cell growth • defense response
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	55540	50905
Ensembl	ENSG00000056736	ENSMUSG00000015966
Uniprot	Q9NRM6	Q543U7
Refseq	NM_172234 (mRNA) NP_758434 (protein)	NM_019583 (mRNA) NP_062529 (protein)
Location	Chr 3: 53.86 - 53.87 Mb	Chr 14: 28.83 - 28.84 Mb
Pubmed search	[1]	[2]

Interleukin 17 receptor B, also known as IL17RB, is a human gene.

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor.

See also

• Interleukin-17 receptor

Further reading

• Schwandner R, Yamaguchi K, Cao Z (2000). "Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction.". J. Exp. Med. 191 (7): 1233-40. PMID 10748240.
• Shi Y, Ullrich SJ, Zhang J, et al. (2000). "A novel cytokine receptor-ligand pair. Identification, molecular characterization, and in vivo immunomodulatory activity.". J. Biol. Chem. 275 (25): 19167-76. doi:10.1074/jbc.M910228199. PMID 10749887.
• Tian E, Sawyer JR, Largaespada DA, et al. (2000). "Evi27 encodes a novel membrane protein with homology to the IL17 receptor.". Oncogene 19 (17): 2098-109. doi:10.1038/sj.onc.1203577. PMID 10815801.
• Lee J, Ho WH, Maruoka M, et al. (2001). "IL-17E, a novel proinflammatory ligand for the IL-17 receptor homolog IL-17Rh1.". J. Biol. Chem. 276 (2): 1660-4. doi:10.1074/jbc.M008289200. PMID 11058597.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance.". Genome Biol. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
• Symmans WF (2006). "Genomic testing for sensitivity of breast cancer to hormonal therapy.". Clin. Cancer Res. 12 (7 Pt 1): 1954-5. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
• Goetz MP, Suman VJ, Ingle JN, et al. (2006). "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen.". Clin. Cancer Res. 12 (7 Pt 1): 2080-7. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019.
• Ma XJ, Hilsenbeck SG, Wang W, et al. (2006). "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer.". J. Clin. Oncol. 24 (28): 4611-9. doi:10.1200/JCO.2006.06.6944. PMID 17008703.

External links

• MeSH IL17RB+protein,+human

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.