P2RY2: Difference between revisions

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{{Infobox_gene}}
 
'''P2Y purinoceptor 2''' is a [[protein]] that in humans is encoded by the ''P2RY2'' [[gene]].<ref name="pmid8159738">{{cite journal | vauthors = Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT | title = Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy | journal = Proc Natl Acad Sci USA | volume = 91 | issue = 8 | pages = 3275–9 |date=May 1994 | pmid = 8159738 | pmc = 43559 | doi =10.1073/pnas.91.8.3275  }}</ref><ref name="pmid9286708">{{cite journal | vauthors = Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ | title = Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family | journal = Genomics | volume = 44 | issue = 1 | pages = 127–30 |date=Nov 1997 | pmid = 9286708 | pmc =  | doi = 10.1006/geno.1997.4841 }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Purinergic receptor P2Y, G-protein coupled, 2
| HGNCid = 8541
| Symbol = P2RY2
| AltSymbols =; HP2U; MGC20088; MGC40010; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R
| OMIM = 600041
| ECnumber = 
| Homologene = 1927
| MGIid = 105107
| GeneAtlas_image1 = PBB_GE_P2RY2_206277_at_tn.png
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0045028 |text = purinergic nucleotide receptor activity, G-protein coupled}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006873 |text = cell ion homeostasis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007200 |text = G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5029
    | Hs_Ensembl = ENSG00000175591
    | Hs_RefseqProtein = NP_002555
    | Hs_RefseqmRNA = NM_002564
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 72606992
    | Hs_GenLoc_end = 72625041
    | Hs_Uniprot = P41231
    | Mm_EntrezGene = 18442
    | Mm_Ensembl = ENSMUSG00000032860
    | Mm_RefseqmRNA = NM_008773
    | Mm_RefseqProtein = NP_032799
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 100870659
    | Mm_GenLoc_end = 100886078
    | Mm_Uniprot = Q3U185
  }}
}}
'''Purinergic receptor P2Y, G-protein coupled, 2''', also known as '''P2RY2''', is a human [[gene]].


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5029| accessdate = }}</ref>
| summary_text = The product of this gene, P2Y<sub>2</sub> belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5029| accessdate = }}</ref>
}}
}}


==See also==
==See also==
* [[P2Y receptor]]
* [[P2Y receptor]]
* [[Denufosol]], a P2Y<sub>2</sub> agonist


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Tokuyama Y, Hara M, Jones EM, ''et al.'' |title=Cloning of rat and mouse P2Y purinoceptors. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 211-8 |year= 1995 |pmid= 7779087 |doi= 10.1006/bbrc.1995.1798 }}
*{{cite journal   |vauthors=Tokuyama Y, Hara M, Jones EM, etal |title=Cloning of rat and mouse P2Y purinoceptors. |journal=Biochem. Biophys. Res. Commun. |volume=211 |issue= 1 |pages= 211–8 |year= 1995 |pmid= 7779087 |doi= 10.1006/bbrc.1995.1798 }}
*{{cite journal | author=Parr CE, Sullivan DM, Paradiso AM, ''et al.'' |title=Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 13067 |year= 1995 |pmid= 7809171 |doi=  }}
*{{cite journal   |vauthors=Parr CE, Sullivan DM, Paradiso AM, etal |title=Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 13067 |year= 1995 |pmid= 7809171 |doi=10.1073/pnas.91.26.13067  | pmc=45582 }}
*{{cite journal | author=Parr CE, Sullivan DM, Paradiso AM, ''et al.'' |title=Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 8 |pages= 3275-9 |year= 1994 |pmid= 8159738 |doi=  }}
*{{cite journal   |vauthors=Erb L, Lustig KD, Sullivan DM, etal |title=Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10449–53 |year= 1993 |pmid= 8248130 |doi=10.1073/pnas.90.22.10449  | pmc=47794 }}
*{{cite journal | author=Erb L, Lustig KD, Sullivan DM, ''et al.'' |title=Functional expression and photoaffinity labeling of a cloned P2U purinergic receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 22 |pages= 10449-53 |year= 1993 |pmid= 8248130 |doi=  }}
*{{cite journal   |vauthors=Dasari VR, Sandhu AK, Mills DC, etal |title=Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1. |journal=Somat. Cell Mol. Genet. |volume=22 |issue= 1 |pages= 75–9 |year= 1996 |pmid= 8643996 |doi=10.1007/BF02374378 }}
*{{cite journal | author=Dasari VR, Sandhu AK, Mills DC, ''et al.'' |title=Mapping of the P2U purinergic receptor gene to human chromosome 11q 13.5-14.1. |journal=Somat. Cell Mol. Genet. |volume=22 |issue= 1 |pages= 75-9 |year= 1996 |pmid= 8643996 |doi=  }}
*{{cite journal   |vauthors=Sullivan DM, Erb L, Anglade E, etal |title=Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells. |journal=J. Neurosci. Res. |volume=49 |issue= 1 |pages= 43–52 |year= 1997 |pmid= 9211988 |doi=10.1002/(SICI)1097-4547(19970701)49:1<43::AID-JNR5>3.0.CO;2-D }}
*{{cite journal  | author=Sullivan DM, Erb L, Anglade E, ''et al.'' |title=Identification and characterization of P2Y2 nucleotide receptors in human retinal pigment epithelial cells. |journal=J. Neurosci. Res. |volume=49 |issue= 1 |pages= 43-52 |year= 1997 |pmid= 9211988 |doi= }}
*{{cite journal  | vauthors=Bogdanov Y, Rubino A, Burnstock G |title=Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. |journal=Life Sci. |volume=62 |issue= 8 |pages= 697–703 |year= 1998 |pmid= 9489506 |doi=10.1016/S0024-3205(97)01168-5  }}
*{{cite journal  | author=Somers GR, Hammet F, Woollatt E, ''et al.'' |title=Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. |journal=Genomics |volume=44 |issue= 1 |pages= 127-30 |year= 1997 |pmid= 9286708 |doi= 10.1006/geno.1997.4841 }}
*{{cite journal  | vauthors=Jin J, Dasari VR, Sistare FD, Kunapuli SP |title=Distribution of P2Y receptor subtypes on haematopoietic cells. |journal=Br. J. Pharmacol. |volume=123 |issue= 5 |pages= 789–94 |year= 1998 |pmid= 9535005 |doi= 10.1038/sj.bjp.0701665  | pmc=1565225 }}
*{{cite journal | author=Bogdanov Y, Rubino A, Burnstock G |title=Characterisation of subtypes of the P2X and P2Y families of ATP receptors in the foetal human heart. |journal=Life Sci. |volume=62 |issue= 8 |pages= 697-703 |year= 1998 |pmid= 9489506 |doi=  }}
*{{cite journal   |vauthors=Tai CJ, Kang SK, Cheng KW, etal |title=Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 4 |pages= 1591–7 |year= 2000 |pmid= 10770202 |doi=10.1210/jc.85.4.1591 }}
*{{cite journal | author=Jin J, Dasari VR, Sistare FD, Kunapuli SP |title=Distribution of P2Y receptor subtypes on haematopoietic cells. |journal=Br. J. Pharmacol. |volume=123 |issue= 5 |pages= 789-94 |year= 1998 |pmid= 9535005 |doi= 10.1038/sj.bjp.0701665 }}
*{{cite journal   |vauthors=Erb L, Liu J, Ockerhausen J, etal |title=An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 491–501 |year= 2001 |pmid= 11331301 |doi=10.1083/jcb.153.3.491  | pmc=2190579  }}
*{{cite journal | author=Tai CJ, Kang SK, Cheng KW, ''et al.'' |title=Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. |journal=J. Clin. Endocrinol. Metab. |volume=85 |issue= 4 |pages= 1591-7 |year= 2000 |pmid= 10770202 |doi=  }}
*{{cite journal   |vauthors=Moore DJ, Chambers JK, Wahlin JP, etal |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107–19 |year= 2001 |pmid= 11690642 |doi=  10.1016/S0167-4781(01)00291-3}}
*{{cite journal | author=Erb L, Liu J, Ockerhausen J, ''et al.'' |title=An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. |journal=J. Cell Biol. |volume=153 |issue= 3 |pages= 491-501 |year= 2001 |pmid= 11331301 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Moore DJ, Chambers JK, Wahlin JP, ''et al.'' |title=Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 107-19 |year= 2001 |pmid= 11690642 |doi= }}
*{{cite journal  | vauthors=Burrell HE, Bowler WB, Gallagher JA, Sharpe GR |title=Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 440–7 |year= 2003 |pmid= 12603858 |doi= 10.1046/j.1523-1747.2003.12050.x }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Schafer R, Sedehizade F, Welte T, Reiser G |title=ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 2 |pages= L376–85 |year= 2003 |pmid= 12691958 |doi= 10.1152/ajplung.00447.2002 }}
*{{cite journal | author=Burrell HE, Bowler WB, Gallagher JA, Sharpe GR |title=Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. |journal=J. Invest. Dermatol. |volume=120 |issue= 3 |pages= 440-7 |year= 2003 |pmid= 12603858 |doi= 10.1046/j.1523-1747.2003.12050.x }}
*{{cite journal   |vauthors=Seye CI, Yu N, Jain R, etal |title=The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24960–5 |year= 2003 |pmid= 12714597 |doi= 10.1074/jbc.M301439200 }}
*{{cite journal | author=Schafer R, Sedehizade F, Welte T, Reiser G |title=ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=285 |issue= 2 |pages= L376-85 |year= 2003 |pmid= 12691958 |doi= 10.1152/ajplung.00447.2002 }}
*{{cite journal   |vauthors=Greig AV, Linge C, Terenghi G, etal |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007–15 |year= 2003 |pmid= 12787128 |doi=10.1046/j.1523-1747.2003.12261.x }}
*{{cite journal  | author=Seye CI, Yu N, Jain R, ''et al.'' |title=The P2Y2 nucleotide receptor mediates UTP-induced vascular cell adhesion molecule-1 expression in coronary artery endothelial cells. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24960-5 |year= 2003 |pmid= 12714597 |doi= 10.1074/jbc.M301439200 }}
*{{cite journal   |vauthors=Greig AV, Linge C, Healy V, etal |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315–27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
*{{cite journal  | author=Greig AV, Linge C, Terenghi G, ''et al.'' |title=Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes. |journal=J. Invest. Dermatol. |volume=120 |issue= 6 |pages= 1007-15 |year= 2003 |pmid= 12787128 |doi= }}
*{{cite journal   |vauthors=Meshki J, Tuluc F, Bredetean O, etal |title=Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor. |journal=Am. J. Physiol., Cell Physiol. |volume=286 |issue= 2 |pages= C264–71 |year= 2004 |pmid= 14613890 |doi= 10.1152/ajpcell.00287.2003 }}
*{{cite journal | author=Greig AV, Linge C, Healy V, ''et al.'' |title=Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells. |journal=J. Invest. Dermatol. |volume=121 |issue= 2 |pages= 315-27 |year= 2003 |pmid= 12880424 |doi= 10.1046/j.1523-1747.2003.12379.x }}
*{{cite journal   |vauthors=Haserück N, Erl W, Pandey D, etal |title=The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. |journal=Blood |volume=103 |issue= 7 |pages= 2585–92 |year= 2004 |pmid= 14645014 |doi= 10.1182/blood-2003-04-1127 }}
*{{cite journal | author=Meshki J, Tuluc F, Bredetean O, ''et al.'' |title=Molecular mechanism of nucleotide-induced primary granule release in human neutrophils: role for the P2Y2 receptor. |journal=Am. J. Physiol., Cell Physiol. |volume=286 |issue= 2 |pages= C264-71 |year= 2004 |pmid= 14613890 |doi= 10.1152/ajpcell.00287.2003 }}
*{{cite journal | author=Haserück N, Erl W, Pandey D, ''et al.'' |title=The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. |journal=Blood |volume=103 |issue= 7 |pages= 2585-92 |year= 2004 |pmid= 14645014 |doi= 10.1182/blood-2003-04-1127 }}
}}
}}
{{refend}}
{{refend}}
==External links==
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2394 | title = P2Y Receptors: P2Y<sub>2</sub> | accessdate = | date = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}
[[Category:G protein coupled receptors]]
{{Purinergics}}
 
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{{WH}}
[[Category:G protein-coupled receptors]]
{{WS}}
{{transmembranereceptor-stub}}

Latest revision as of 18:01, 24 September 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

P2Y purinoceptor 2 is a protein that in humans is encoded by the P2RY2 gene.[1][2]

The product of this gene, P2Y2 belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to both adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial carcinoma cells. Three transcript variants encoding the same protein have been identified for this gene.[3]

See also

References

  1. ↑ Parr CE, Sullivan DM, Paradiso AM, Lazarowski ER, Burch LH, Olsen JC, Erb L, Weisman GA, Boucher RC, Turner JT (May 1994). "Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy". Proc Natl Acad Sci USA. 91 (8): 3275–9. doi:10.1073/pnas.91.8.3275. PMC 43559. PMID 8159738.
  2. ↑ Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Nov 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
  3. ↑ "Entrez Gene: P2RY2 purinergic receptor P2Y, G-protein coupled, 2".

Further reading

External links

  • "P2Y Receptors: P2Y2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=P2RY2&oldid=1527791"