EGF module-containing mucin-like hormone receptor

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egf-like module containing, mucin-like, hormone receptor-like 1
Identifiers
SymbolEMR1
Alt. symbolsTM7LN3
IUPHAR182
Entrez2015
HUGO3336
OMIM600493
RefSeqNM_001974
UniProtQ14246
Other data
LocusChr. 19 p13.3
egf-like module containing, mucin-like, hormone receptor-like 2
Identifiers
SymbolEMR2
IUPHAR183
Entrez30817
HUGO3337
OMIM606100
RefSeqNM_152916
UniProtQ9UHX3
Other data
LocusChr. 19 p13.1
egf-like module containing, mucin-like, hormone receptor-like 3
Identifiers
SymbolEMR3
IUPHAR184
Entrez84658
HUGO23647
OMIM606101
RefSeqNM_032571
UniProtQ9BY15
Other data
LocusChr. 19 p13.1
egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
SymbolEMR4P
Alt. symbolsGPR127
Entrez326342
HUGO19240
RefSeqXM_940358
UniProtQ86SQ3
Other data
LocusChr. 19 p13.3

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1-4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.[5]

References

  1. Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, Lipinski M (1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–44. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
  2. Lin HH, Stacey M, Hamann J, Gordon S, McKnight AJ (2000). "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics. 67 (2): 188–200. doi:10.1006/geno.2000.6238. PMID 10903844.
  3. Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (2001). "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. doi:10.1074/jbc.M101147200. PMID 11279179.
  4. Caminschi I, Vandenabeele S, Sofi M, McKnight AJ, Ward N, Brodnicki TC, Toy T, Lahoud M, Maraskovsky E, Shortman K, Wright MD (2006). "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. doi:10.1080/10425170500355737. PMID 16753812.
  5. Kwakkenbos MJ, Kop EN, Stacey M, Matmati M, Gordon S, Lin HH, Hamann J (2004). "The EGF-TM7 family: a postgenomic view". Immunogenetics. 55 (10): 655–66. doi:10.1007/s00251-003-0625-2. PMID 14647991.

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