Etazolate

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Etazolate
Etazolate.png
Clinical data
SynonymsEtazolate
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC14H19N5O2
Molar mass289.33 g/mol
3D model (JSmol)

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Overview

Etazolate is a pyrazolopyridine derivative drug,[1] which acts as an anxiolytic.[2]

It has several mechanisms of action, acting as an adenosine antagonist,[3] a subtype-selective GABAA receptor partial agonist,[4] and a phosphodiesterase inhibitor selective for the PDE4 subtype.[5]


See also

References

  1. Ticku MK, Davis WC (1982). "Molecular interactions of etazolate with benzodiazepine and picrotoxinin binding sites". J. Neurochem. 38 (4): 1180–2. PMID 6278085.
  2. Williams M. Anxioselective anxiolytics. Journal of Medicinal Chemistry. 1983 May;26(5):619-28. PMID 6132997
  3. Williams M, Jarvis MF. Adenosine antagonists as potential therapeutic agents. Pharmacology Biochemistry and Behaviour. 1988 Feb;29(2):433-41. PMID 3283781
  4. Zezula J, Slany A, Sieghart W. Interaction of allosteric ligands with GABAA receptors containing one, two, or three different subunits. European Journal of Pharmacology. 1996 Apr 22;301(1-3):207-14. PMID 8773466
  5. Wang P, Myers JG, Wu P, Cheewatrakoolpong B, Egan RW, Billah MM. Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. Biochemical and Biophysical Research Communications. 1997 May 19;234(2):320-4. PMID 9177268




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