Melanocortin 3 receptor

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
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RefSeq (mRNA)

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RefSeq (protein)

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Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene.[1][2]

Function

This gene encodes MC3, a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis.[2]

Research

Studies performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), found that two specific polymorphisms in the MC3R gene may be associated with pediatric obesity and greater body mass because of greater energy intake. Children who were homozygous for C17A + G241A consumed approximately 38% more than those who did not contain aforementioned polymorphisms. The study concluded that these genetic variants did not affect energy expenditure.[3]

See also

References

  1. Gantz I, Konda Y, Tashiro T, Shimoto Y, Miwa H, Munzert G, Watson SJ, DelValle J, Yamada T (April 1993). "Molecular cloning of a novel melanocortin receptor". The Journal of Biological Chemistry. 268 (11): 8246–50. PMID 8463333.
  2. 2.0 2.1 "Entrez Gene: MC3R melanocortin 3 receptor".
  3. Savastano DM, Tanofsky-Kraff M, Han JC, Ning C, Sorg RA, Roza CA, Wolkoff LE, Anandalingam K, Jefferson-George KS, Figueroa RE, Sanford EL, Brady S, Kozlosky M, Schoeller DA, Yanovski JA (October 2009). "Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor". The American Journal of Clinical Nutrition. 90 (4): 912–20. doi:10.3945/ajcn.2009.27537. PMC 2744620. PMID 19656839.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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