Retinoic acid-inducible orphan G protein-coupled receptor

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G protein-coupled receptor, family C, group 5, member A
Identifiers
SymbolGPRC5A
Alt. symbolsRAIG1, RAI3
Entrez9052
HUGO9836
OMIM604138
RefSeqNM_003979
UniProtQ8NFJ5
Other data
LocusChr. 12 p13-p12.3
G protein coupled receptor, family C, group 5, member B
Identifiers
SymbolGPRC5B
Alt. symbolsRAIG2
Entrez51704
HUGO13308
OMIM605948
RefSeqNM_016235
UniProtQ9NZH0
Other data
LocusChr. 16 p12
G protein-coupled receptor, family C, group 5, member C
Identifiers
SymbolGPRC5C
Alt. symbolsRAIG3
Entrez55890
HUGO13309
OMIM605949
RefSeqNM_022036
UniProtQ9NQ84
Other data
LocusChr. 17 q25
G protein-coupled receptor, family C, group 5, member D
Identifiers
SymbolGPRC5D
Entrez55507
HUGO13310
OMIM607437
RefSeqNM_018654
UniProtQ9NZD1
Other data
LocusChr. 12 p13.3

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

References

  1. Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
  2. Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  3. Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  4. Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
  5. Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.

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