GPR12

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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[1][2][3]

The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity[4].


References

  1. Saeki Y, Ueno S, Mizuno R, Nishimura T, Fujimura H, Nagai Y, Yanagihara T (Jan 1994). "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Lett. 336 (2): 317–322. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
  2. Song ZH, Modi W, Bonner TI (Feb 1996). "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics. 28 (2): 347–349. doi:10.1006/geno.1995.1154. PMID 8530049.
  3. "Entrez Gene: GPR12 G protein-coupled receptor 12".
  4. Bjursell, Mikael; Gerdin, Anna-Karin; Jönsson, Marie; Surve, Vikas V.; Svensson, Lennart; Huang, Xu-Feng; Törnell, Jan; Bohlooly-Y, Mohammad (2006-09-22). "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications. 348 (2): 359–366. doi:10.1016/j.bbrc.2006.07.090. ISSN 0006-291X. PMID 16887097.

Further reading


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