Free fatty acid receptor

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free fatty acid receptor 1
Identifiers
SymbolFFAR1, FFA1R
Alt. symbolsGPR40
Entrez2864
HUGO4498
OMIM603820
RefSeqNM_005303
UniProtO14842
Other data
LocusChr. 19 q13.1
free fatty acid receptor 2
Identifiers
SymbolFFAR2
Alt. symbolsGPR43, FFA2R
Entrez2867
HUGO4501
OMIM603823
RefSeqNM_005306
UniProtO15552
Other data
LocusChr. 19 q13.1
free fatty acid receptor 3
Identifiers
SymbolFFAR3
Alt. symbolsGPR41, FFA3R
Entrez2865
HUGO4499
OMIM603821
RefSeqNM_005304
UniProtO14843
Other data
LocusChr. 19 q13.1
G protein-coupled receptor 42
Identifiers
SymbolGPR42
Alt. symbolsGPR41L, FFAR1L
Entrez2866
HUGO4500
OMIM603822
RefSeqNM_005305
UniProtO15529
Other data
LocusChr. 19 q31.1

The free fatty acid receptor is a G-protein coupled receptor which binds free fatty acids.[1] There are four variants of the receptor, each encoded by a separate gene (FFAR1, FFAR2, FFAR3, FFAR4). Preliminary findings suggest that FFAR2 and FFAR3 may interact to form a FFAR2-FFAR3 receptor heteromer. [2]

References

  1. Covington DK, Briscoe CA, Brown AJ, Jayawickreme CK (2006). "The G-protein-coupled receptor 40 family (GPR40-GPR43) and its role in nutrient sensing". Biochem. Soc. Trans. 34 (Pt 5): 770–3. doi:10.1042/BST0340770. PMID 17052194.
  2. Ang, Zhiwei; Xiong, Ding; Wu, Min; Ding, Jeak Ling (2017-09-07). "FFAR2-FFAR3 receptor heteromerization modulates short-chain fatty acid sensing". The FASEB Journal. 32: –201700252RR. doi:10.1096/fj.201700252RR. ISSN 0892-6638. PMC 5731126. PMID 28883043. Retrieved 2017-09-10.

External links


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