FZD8

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.[1][2]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

See also

References

  1. Saitoh T, Hirai M, Katoh M (Apr 2001). "Molecular cloning and characterization of human Frizzled-8 gene on chromosome 10p11.2". Int J Oncol. 18 (5): 991–6. doi:10.3892/ijo.18.5.991. PMID 11295046.
  2. 2.0 2.1 "Entrez Gene: FZD8 frizzled homolog 8 (Drosophila)".

Further reading

External links

  • "Frizzled Receptors: FZD8". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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