Tachykinin receptor

tachykinin receptor 1
Identifiers
Symbol	TACR1
Alt. symbols	TAC1R
Entrez	6869
HUGO	11526
OMIM	162323
RefSeq	NM_001058
UniProt	P25103
Other data
Locus	Chr. 2 p13.1-p12

tachykinin receptor 2
Identifiers
Symbol	TACR2
Alt. symbols	TAC2R, NKNAR
Entrez	6865
HUGO	11527
OMIM	162321
RefSeq	NM_001057
UniProt	P21452
Other data
Locus	Chr. 10 q11-q21

tachykinin receptor 3
Identifiers
Symbol	TACR3
Entrez	6870
HUGO	11528
OMIM	162332
RefSeq	NM_001059
UniProt	P29371
Other data
Locus	Chr. 4 q25

There are three known mammalian tachykinin receptors termed NK₁, NK₂ and NK₃. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called G_q-coupled).

Binding

The genes and receptor ligands are as follows:

Receptor	Gene	Preferred ligand
NK1	TACR1	substance P
NK2	TACR2	neurokinin A
NK3	TACR3	neurokinin B

(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)

See also

• Substance P
• G protein coupled receptors

External links

• "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
• Tachykinin+Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)