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'''Lysophosphatidic acid receptor 6''' also known as '''LPA<sub>6</sub>''', '''P2RY5''', and '''GPR87''', is a [[protein]] that in humans is encoded by the ''LPAR6'' [[gene]].<ref name="pmid11004484">{{cite journal |vauthors=Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochim Biophys Acta | volume = 1492 | issue = 1 | pages = 127–38 |date=Sep 2000 | pmid = 11004484 | pmc = | doi = 10.1016/S0167-4781(00)00094-4}}</ref><ref name="pmid9755289">{{cite journal |vauthors=Ralevic V, Burnstock G | title = Receptors for purines and pyrimidines | journal = Pharmacol Rev | volume = 50 | issue = 3 | pages = 413–92 |date=Nov 1998 | pmid = 9755289 | pmc = | doi = }}</ref><ref name="pmid19386608">{{cite journal |vauthors=Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S | title = Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 | journal = J Biol Chem | volume = 284 | issue = 26 | pages = 17731–41 |date=Jun 2009 | pmid = 19386608 | pmc = 2719412 | doi = 10.1074/jbc.M808506200 }}</ref><ref name="entrez"/> LPA<sub>6</sub> is a [[G protein-coupled receptor]] that binds the lipid signaling molecule [[lysophosphatidic acid]] (LPA).<ref name="pmid18297070">{{cite journal |vauthors=Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC | title = G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | journal = Nat. Genet. | volume = 40 | issue = 3 | pages = 329–34 |date=March 2008 | pmid = 18297070 | doi = 10.1038/ng.84 | url = | issn = }}</ref><ref name = "Choi_2010">{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J |date=January 2010 | title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = | '''Lysophosphatidic acid receptor 6''' also known as '''LPA<sub>6</sub>''', '''P2RY5''', and '''GPR87''', is a [[protein]] that in humans is encoded by the ''LPAR6'' [[gene]].<ref name="pmid11004484">{{cite journal |vauthors=Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochim Biophys Acta | volume = 1492 | issue = 1 | pages = 127–38 |date=Sep 2000 | pmid = 11004484 | pmc = | doi = 10.1016/S0167-4781(00)00094-4}}</ref><ref name="pmid9755289">{{cite journal |vauthors=Ralevic V, Burnstock G | title = Receptors for purines and pyrimidines | journal = Pharmacol Rev | volume = 50 | issue = 3 | pages = 413–92 |date=Nov 1998 | pmid = 9755289 | pmc = | doi = }}</ref><ref name="pmid19386608">{{cite journal |vauthors=Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S | title = Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 | journal = J Biol Chem | volume = 284 | issue = 26 | pages = 17731–41 |date=Jun 2009 | pmid = 19386608 | pmc = 2719412 | doi = 10.1074/jbc.M808506200 }}</ref><ref name="entrez"/> LPA<sub>6</sub> is a [[G protein-coupled receptor]] that binds the lipid signaling molecule [[lysophosphatidic acid]] (LPA).<ref name="pmid18297070">{{cite journal |vauthors=Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC | title = G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | journal = Nat. Genet. | volume = 40 | issue = 3 | pages = 329–34 |date=March 2008 | pmid = 18297070 | doi = 10.1038/ng.84 | url = | issn = }}</ref><ref name = "Choi_2010">{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J |date=January 2010 | title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | pmid=20055701}}</ref> | ||
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*{{cite journal |vauthors=Toguchida J, McGee TL, Paterson JC, etal |title=Complete genomic sequence of the human retinoblastoma susceptibility gene. |journal=Genomics |volume=17 |issue= 3 |pages= 535–43 |year= 1993 |pmid= 7902321 |doi= 10.1006/geno.1993.1368 }} | *{{cite journal |vauthors=Toguchida J, McGee TL, Paterson JC, etal |title=Complete genomic sequence of the human retinoblastoma susceptibility gene. |journal=Genomics |volume=17 |issue= 3 |pages= 535–43 |year= 1993 |pmid= 7902321 |doi= 10.1006/geno.1993.1368 }} | ||
*{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal |vauthors=Herzog H, Darby K, Hort YJ, Shine J |title=Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. |journal=Genome Res. |volume=6 |issue= 9 |pages= 858–61 |year= 1997 |pmid= 8889552 |doi=10.1101/gr.6.9.858 }} | *{{cite journal |vauthors=Herzog H, Darby K, Hort YJ, Shine J |title=Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. |journal=Genome Res. |volume=6 |issue= 9 |pages= 858–61 |year= 1997 |pmid= 8889552 |doi=10.1101/gr.6.9.858 }} | ||
*{{cite journal |vauthors=Li Q, Schachter JB, Harden TK, Nicholas RA |title=The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 455–60 |year= 1997 |pmid= 9240460 |doi= 10.1006/bbrc.1997.6984 }} | *{{cite journal |vauthors=Li Q, Schachter JB, Harden TK, Nicholas RA |title=The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 455–60 |year= 1997 |pmid= 9240460 |doi= 10.1006/bbrc.1997.6984 }} | ||
*{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= | *{{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 }} | ||
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | *{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }} | ||
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[[Category:G protein coupled receptors]] | [[Category:G protein-coupled receptors]] | ||
{{transmembranereceptor-stub}} | {{transmembranereceptor-stub}} | ||
Revision as of 13:29, 7 November 2018
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Lysophosphatidic acid receptor 6 also known as LPA6, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene.[1][2][3][4] LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[5][6]
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.[4]
Role in hair growth/loss
In February 2008 researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss.[5]
See also
References
- ↑ Adrian K, Bernhard MK, Breitinger HG, Ogilvie A (Sep 2000). "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochim Biophys Acta. 1492 (1): 127–38. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
- ↑ Ralevic V, Burnstock G (Nov 1998). "Receptors for purines and pyrimidines". Pharmacol Rev. 50 (3): 413–92. PMID 9755289.
- ↑ Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S (Jun 2009). "Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6". J Biol Chem. 284 (26): 17731–41. doi:10.1074/jbc.M808506200. PMC 2719412. PMID 19386608.
- ↑ 4.0 4.1 "Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5".
- ↑ 5.0 5.1 Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC (March 2008). "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth". Nat. Genet. 40 (3): 329–34. doi:10.1038/ng.84. PMID 18297070.
- ↑ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology. 50 (1): 157–186. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
Further reading
- Toguchida J, McGee TL, Paterson JC, et al. (1993). "Complete genomic sequence of the human retinoblastoma susceptibility gene". Genomics. 17 (3): 535–43. doi:10.1006/geno.1993.1368. PMID 7902321.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Herzog H, Darby K, Hort YJ, Shine J (1997). "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene". Genome Res. 6 (9): 858–61. doi:10.1101/gr.6.9.858. PMID 8889552.
- Li Q, Schachter JB, Harden TK, Nicholas RA (1997). "The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses". Biochem. Biophys. Res. Commun. 236 (2): 455–60. doi:10.1006/bbrc.1997.6984. PMID 9240460.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ihara H, Hirukawa K, Goto S, Togari A (2005). "ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts". Biochem. Biophys. Res. Commun. 326 (2): 329–34. doi:10.1016/j.bbrc.2004.11.037. PMID 15582581.
External links
- LPAR6 human gene location in the UCSC Genome Browser.
- LPAR6 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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