Piritramide

Jump to navigation Jump to search
Piritramide
Clinical data
Trade namesDipidolor
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • No teratogenic effects in preclinical studies; but, as with other opioids it may cause reversible adverse effects in the newborn.
Routes of
administration
Oral, IM, IV
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding95%[1]
MetabolismLiver
Elimination half-life4-10 hours (acute dosing), 17.4 hours (chronic dosing)
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC27H34N4O
Molar mass430.585 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Piritramide

Articles

Most recent articles on Piritramide

Most cited articles on Piritramide

Review articles on Piritramide

Articles on Piritramide in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Piritramide

Images of Piritramide

Photos of Piritramide

Podcasts & MP3s on Piritramide

Videos on Piritramide

Evidence Based Medicine

Cochrane Collaboration on Piritramide

Bandolier on Piritramide

TRIP on Piritramide

Clinical Trials

Ongoing Trials on Piritramide at Clinical Trials.gov

Trial results on Piritramide

Clinical Trials on Piritramide at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Piritramide

NICE Guidance on Piritramide

NHS PRODIGY Guidance

FDA on Piritramide

CDC on Piritramide

Books

Books on Piritramide

News

Piritramide in the news

Be alerted to news on Piritramide

News trends on Piritramide

Commentary

Blogs on Piritramide

Definitions

Definitions of Piritramide

Patient Resources / Community

Patient resources on Piritramide

Discussion groups on Piritramide

Patient Handouts on Piritramide

Directions to Hospitals Treating Piritramide

Risk calculators and risk factors for Piritramide

Healthcare Provider Resources

Symptoms of Piritramide

Causes & Risk Factors for Piritramide

Diagnostic studies for Piritramide

Treatment of Piritramide

Continuing Medical Education (CME)

CME Programs on Piritramide

International

Piritramide en Espanol

Piritramide en Francais

Business

Piritramide in the Marketplace

Patents on Piritramide

Experimental / Informatics

List of terms related to Piritramide

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Piritramide (R-3365, trade names Dipidolor, Piridolan, Pirium and others) is a synthetic opioid analgesic (narcotic painkiller) that is marketed in certain European countries including: Austria, Belgium, Czech Republic, Germany and the Netherlands.[2] It comes in free form, is about 0.75x times as potent as morphine and is given parenterally (by injection) for the treatment of severe pain.[2][3] Nausea, vomiting, respiratory depression and constipation are believed to be less frequent with piritramide than with morphine (which is the gold standard opioid against which other opioids are compared and contrasted against) and it produces more rapid-onset analgesia (pain relief) when compared to morphine and pethidine, after intravenous administration the onset of analgesia is as little as 1–2 minutes, which may be related to its great lipophilicity.[4] The analgesic and sedative effects of piritramide are believed to be potentiated with phenothiazines and its emetic (nausea/vomiting-inducing) effects are suppressed.[4] The volume of distribution is 0.7-1 L/kg after a single dose, 4.7-6 L/kg after steady-state concentrations are achieved and up to 11.1 L/kg after prolonged dosing.[4]

History & Regulation

Piritramide was developed and patented in the Netherlands, at Janssen, in 1960. It is part of an eponymous two-member class of opioids in clinical use with the other being bezitramide (Burgodin). The closest chemical and structural relatives of piritramide in clinical use include the diphenoxylate family, fentanyl (both Janssen discoveries) and somewhat more distantly alphaprodine.

Not being in clinical use in the United States, it is a Schedule I Narcotic controlled substance with a DEA ACSCN of 9642 and manufacturing quota of zero.[5] It presumably has abuse potential, and appears on the European black market on occasion and has a handful of street names including "Pierrette" and "P".[6] LEXIS-NEXIS and other database searches do not show mentions of law enforcement contact with this drug in the United States. Piritramide is specifically exempted from the Canadian controlled-substances law, and its relative bezitramide is a Schedule II controlled substance in the US, although not used there as of 2014.

Synthesis

See also

References

  1. Jage, J; Laufenberg-Feldmann, R; Heid, F (May 2008). "Medikamente zur postoperativen Schmerztherapie: Bewährtes und Neues". Der Anaesthesist (in German). 57 (5): 491–8. doi:10.1007/s00101-008-1327-9. PMID 18409073. Unknown parameter |trans_title= ignored (help)
  2. 2.0 2.1 Brayfield, A, ed. (23 September 2011). "Piritramide". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 22 April 2014.
  3. Kay, B (December 1971). "A clinical investigation of piritramide in the treatment of postoperative pain". British Journal of Anaesthesia. 43 (12): 1167–71. doi:10.1093/bja/43.12.1167. PMID 4945251.
  4. 4.0 4.1 4.2 "FACHINFORMATION (Zusammenfassung der Merkmale des Arzneimittels)" (PDF). Janssen. Janssen - Cilag Pharma GmbH. November 2013. Retrieved 9 April 2014. Unknown parameter |trans_title= ignored (help)
  5. http://www.deadiversion.usdoj.gov/fed_regs/quotas/2013/fr0620.htm
  6. Inside Narcotics, 5th Edition, pp 347 (sidebar) "Piritramide -- what they say - Wien 8/iii/2002"