DPI-3290

DPI-3290
Gene therapy
Clinical data
Physiological data
Legal status
Pharmacokinetic data
Identifiers
	IUPAC name (+)-3-((αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide;
PubChem Template:Abbreviation	5242141;
Chemical and physical data
Formula	C30H34FN3O2
Molar mass	487.607 g/mol
3D model (JSmol)	Interactive image;
	SMILES c2c(O)cccc2C(N(CC1C)C(C)CN1CC=C)c(ccc3)cc3C(=O)N(C)c4cc(F)ccc4;

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

DPI-3290 is a drug which is used in scientific research. It is a potent analgesic drug,^[1] which produces little respiratory depression.^[2]

DPI-3290 acts as an agonist at both μ- and δ-opioid receptors, with an IC50 of 6.2nM at μ and 1.0nM at δ.^[3]

↑ Gengo PJ, Pettit HO, O'Neill SJ, Wei K, McNutt R, Bishop MJ, Chang KJ. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. Journal of Pharmacology and Experimental Therapeutics. 2003 Dec;307(3):1221-6. PMID 14534368
↑ Gengo PJ, Pettit HO, O'Neill SJ, Su YF, McNutt R, Chang KJ. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. Journal of Pharmacology and Experimental Therapeutics. 2003 Dec;307(3):1227-33. PMID 14534367
↑ Ananthan S. Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics. AAPS Journal. 2006 Mar 10;8(1):E118-25. PMID 16584118