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Clinical data
SynonymsPropiram, Algeril
Legal status
Legal status
Pharmacokinetic data
Elimination half-life5.2 hours
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
Molar mass275.39 g/mol

Propiram (Algeril) is an opioid analgesic from the ampromide family of drugs. It was invented in the 1970s but was not widely marketed, although it saw some limited clinical use, especially in dentistry.

Propiram is an effective analgesic comparable to other drugs such as codeine and pethidine, with a normal dose of around 50-100mg.[1] It is more potent and effective than codeine,[2] and longer lasting and with a faster onset of action compared to pethidine.[3] Side effects include sedation, dizziness, nausea and vomiting.[4]



  1. Wilson RS, Landers JH. Use of a new oral analgesic, propiram fumarate, in treating postoperative ocular pain. Annals of Ophthalmology. 1982 Dec;14(12):1172-4.
  2. Desjardins PJ, Cooper SA, Gallegos TL, Allwein JB, Reynolds DC, Kruger GO, Beaver WT. The relative analgesic efficacy of propiram fumarate, codeine, aspirin, and placebo in post-impaction dental pain. Journal of Clinical Pharmacology. 1984 Jan;24(1):35-42.
  3. Korduba CA, Veals J, Radwanski E, Symchowicz S, Chung M. Bioavailability of orally administered propiram fumarate in humans. Journal of Pharmaceutical Sciences. 1981 May;70(5):521-3.
  4. Goa KL, Brogden RN. Propiram. A review of its pharmacodynamic and pharmacokinetic properties, and clinical use as an analgesic. Drugs. 1993 Sep;46(3):428-45.