Propacetamol

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Propacetamol
Propacetamol.png
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration
IV[1][2]
ATC code
Pharmacokinetic data
Elimination half-life2.4 hours [1]
ExcretionRenal
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
E number{{#property:P628}}
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Chemical and physical data
FormulaC14H20N2O3
Molar mass264.3202 g/mol
3D model (JSmol)
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Propacetamol is a prodrug form of paracetamol which is formed from esterification of paracetamol, and the carboxylic acid diethylglycine. This has the advantage of making it more water-soluble. It is used in post-operative care and is delivered by I.V.[2] It is given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated. The onset of analgaesia from propacetamol is more rapid than paracetamol given orally.[3] 2 g of propacetamol are equivalent to 1g of paracetamol.[4]

See also

References

  1. 1.0 1.1 Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A (1992). "Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol" (pdf). British Journal of Clinical Pharmacology. 34 (1): 79–81. doi:10.1111/j.1365-2125.1992.tb04112.x. PMC 1381380. PMID 1633071.
  2. 2.0 2.1 Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P (2004). "Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]" (pdf). BMC Anesthesiology. 4 (1): 6. doi:10.1186/1471-2253-4-6. PMC 520811. PMID 15367329.
  3. Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA (2005). "Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery" (pdf). British Journal of Anaesthesiology. 94 (5): 642–648. doi:10.1093/bja/aei109. PMID 15790675.
  4. Flouvat B, Leneveu A, Fitoussi S, Delhotal-Landes B, Gendron A (2004). "Bioequivalence study comparing a new paracetamol solution for injection and propacetamol after single intravenous infusion in healthy subjects". International Journal of Clinical Pharmacology and Therapeutics. 42 (1): 50–57. doi:10.5414/cpp42050. PMID 14756388.