AM404

Jump to: navigation, search
AM404
AM404.png
Legal status
Legal status
Identifiers
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC26H37NO2
Molar mass395.59 g·mol−1

WikiDoc Resources for AM404

Articles

Most recent articles on AM404

Most cited articles on AM404

Review articles on AM404

Articles on AM404 in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on AM404

Images of AM404

Photos of AM404

Podcasts & MP3s on AM404

Videos on AM404

Evidence Based Medicine

Cochrane Collaboration on AM404

Bandolier on AM404

TRIP on AM404

Clinical Trials

Ongoing Trials on AM404 at Clinical Trials.gov

Trial results on AM404

Clinical Trials on AM404 at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on AM404

NICE Guidance on AM404

NHS PRODIGY Guidance

FDA on AM404

CDC on AM404

Books

Books on AM404

News

AM404 in the news

Be alerted to news on AM404

News trends on AM404

Commentary

Blogs on AM404

Definitions

Definitions of AM404

Patient Resources / Community

Patient resources on AM404

Discussion groups on AM404

Patient Handouts on AM404

Directions to Hospitals Treating AM404

Risk calculators and risk factors for AM404

Healthcare Provider Resources

Symptoms of AM404

Causes & Risk Factors for AM404

Diagnostic studies for AM404

Treatment of AM404

Continuing Medical Education (CME)

CME Programs on AM404

International

AM404 en Espanol

AM404 en Francais

Business

AM404 in the Marketplace

Patents on AM404

Experimental / Informatics

List of terms related to AM404


AM404 also known as N-arachidonoylphenolamine is an active metabolite of paracetamol (acetaminophen) responsible for all or part of its analgesic action.

Pharmacology

AM404 has been noted as an endogenous cannabinoid reuptake inhibitor, preventing the transport of anandamide and other related compounds back from the synaptic cleft, much in the same way that common SSRI antidepressants prevent the reuptake of serotonin. AM404 is also TRPV1 agonist, and also prevents cyclooxygenase COX-1 and COX-2 and prostaglandin synthesis. AM404 is thought to induce its analgesic action through its activity on the cannabinoid, COX and TRPV systems, all of which are present in pain and thermoregulatory pathways.[1]

References

  1. Högestätt, E. D., B. A. G. Jönsson, A. Ermund, D. A. Andersson, H. Björk, J. P. Alexander, B. F. Cravatt, A. I. Basbaum, P. M. Zygmunt (September 9, 2005). "Conversion of Acetaminophen to the Bioactive N-Acylphenolamine AM404 via Fatty Acid Amide Hydrolase-dependent Arachidonic Acid Conjugation in the Nervous System". Journal of Biological Chemistry. 280 (36): 31405–31412. doi:10.1074/jbc.M501489200. Retrieved 2006-04-25. Check date values in: |date= (help)

Linked-in.jpg