Jump to navigation Jump to search
Clinical data
SynonymsAcetyldihydrocodeine, Dihydrothebacone, 6-acetyl-7,8-dihydrocodeine
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass343.417 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Acetyldihydrocodeine


Most recent articles on Acetyldihydrocodeine

Most cited articles on Acetyldihydrocodeine

Review articles on Acetyldihydrocodeine

Articles on Acetyldihydrocodeine in N Eng J Med, Lancet, BMJ


Powerpoint slides on Acetyldihydrocodeine

Images of Acetyldihydrocodeine

Photos of Acetyldihydrocodeine

Podcasts & MP3s on Acetyldihydrocodeine

Videos on Acetyldihydrocodeine

Evidence Based Medicine

Cochrane Collaboration on Acetyldihydrocodeine

Bandolier on Acetyldihydrocodeine

TRIP on Acetyldihydrocodeine

Clinical Trials

Ongoing Trials on Acetyldihydrocodeine at Clinical

Trial results on Acetyldihydrocodeine

Clinical Trials on Acetyldihydrocodeine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Acetyldihydrocodeine

NICE Guidance on Acetyldihydrocodeine


FDA on Acetyldihydrocodeine

CDC on Acetyldihydrocodeine


Books on Acetyldihydrocodeine


Acetyldihydrocodeine in the news

Be alerted to news on Acetyldihydrocodeine

News trends on Acetyldihydrocodeine


Blogs on Acetyldihydrocodeine


Definitions of Acetyldihydrocodeine

Patient Resources / Community

Patient resources on Acetyldihydrocodeine

Discussion groups on Acetyldihydrocodeine

Patient Handouts on Acetyldihydrocodeine

Directions to Hospitals Treating Acetyldihydrocodeine

Risk calculators and risk factors for Acetyldihydrocodeine

Healthcare Provider Resources

Symptoms of Acetyldihydrocodeine

Causes & Risk Factors for Acetyldihydrocodeine

Diagnostic studies for Acetyldihydrocodeine

Treatment of Acetyldihydrocodeine

Continuing Medical Education (CME)

CME Programs on Acetyldihydrocodeine


Acetyldihydrocodeine en Espanol

Acetyldihydrocodeine en Francais


Acetyldihydrocodeine in the Marketplace

Patents on Acetyldihydrocodeine

Experimental / Informatics

List of terms related to Acetyldihydrocodeine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


Acetyldihydrocodeine is an opiate derivative discovered in Germany in 1914[1] and was used as a cough suppressant and analgesic. It is not commonly used, but has activity similar to other opiates. Acetyldihydrocodeine is a very close relative derivative of Thebacon, where only the 6-7 double bond is unsaturated. Acetyldihydrocodeine can be described as the 6-acetyl derivative of dihydrocodeine and is metabolised in the liver by demethylation and deacetylation to produce dihydromorphine.

Since acetyldihydrocodeine has higher lipophilicity than codeine and is converted into dihydromorphine rather than morphine, it can be expected to be more potent and longer lasting, and also have higher bioavailability than codeine. Side effects are similar to those of other opiates and include itching, nausea and respiratory depression.

Although an opioid of low to moderate strength and use in medicine elsewhere in the world, acetyldihydrocodeine is a Schedule I controlled substance in the United States. Its DEA Administrative Controlled Substances Control Number is 9051 and the one salt in use, acetyldihydrocodeine hydrochloride, has a freebase conversion ratio of 0.90. The 2013 annual production quota from the DEA is 2 grammes.


  1. v. Braun, J. (1914). "Untersuchungen über Morphium-Alkaloide". Chemische Berichte. 47 (2): 2312–2330. doi:10.1002/cber.191404702149.

Template:Cough and cold preparations