Anxiety causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]


Life threatening causes of anxiety include anaphylaxis, acute coronary syndromes, cardiogenic shock, and myocardial infarction. Other common causes include anemia, caffeine, diabetes, and hyperthyroidism.


Life Threatening Causes

Common Causes

Causes by Organ System


Cardiovascular Accelerated hypertension , Acute Coronary Syndromes, Angina pectoris, Aortic aneurysm, Bacterial pericarditis, Cardiac arrhythmia, Cardiac tamponade, Cardiogenic shock, Cerebrovascular disease, Chest pain, chronic orthostatic hypotension, Congenital heart disease, Congestive cardiac failure, Constrictive pericarditis , constrictive tuberculous pericarditis , decreased cardiac output, Heart disease, Hypertension, Mitral valve prolapse, Myocardial infarction, Orthostatic intolerance, Postural orthostatic tachycardia syndrome, Sinus arrhythmia, Sinus node disease, Sinus tachycardia Supraventricular tachycardia
Chemical / poisoning Amines, Barium nitrate, Carbamate insecticide poisoning, Carbon disulfide,Lead poisoning, Manganese, Mercury, Organophosphate poisoning
Dermatologic Acne, insect bite allergy, lupus, Pellagra, Vitiligo
Drug Side Effect Acamprosate calcium, Acetaminophen, alpha-methyltryptamine, amantadine, amobarbital sodium, amphetamine, antidepressants, anorexia nervosa, aripiprazole, armodafinil, bortezomib, buprenorphine, bupropion, buspirone, butorphanol, caffeine, cannabis, carbamazepine, cimetidine, clobazam, clofarabine Injection, cocaine, caspofungin acetate, cyclosporine, dexamethasone Oral, dextroamphetamine and Amphetamine, dicyclomine, diphenhydramine, doxylamine, ECA stack, efavirenz, enoxacin, epinephrine (aerosol), ethcathinone, ethynodiol diacetate and ethinyl estradiol, Fentanyl fludrocortisone acetate, fluticasone Oral Inhalation , fluoxetine, fluphenazine, fluticasone Oral Inhalation, gabapentin, ginseng, paroxetine, pergolide, phencyclidine, phenylephrine
Ear Nose Throat Burning mouth syndrome, cholesteatoma, infectious mononucleosis, middle ear infection
Endocrine Addison's disease, adrenal cortex diseases, adrenal gland hypofunction, autoimmune thyroid diseases, Graves disease, adrenal hypertension, adrenal tumor, anorexia nervosa, autoimmune thyroid diseases, carcinoid syndrome, congenital adrenal hyperplasia, conn syndrome-induced hypertension, cushing's disease, cushing syndrome, diabetes, eating disorder, Ectopic ACTH Syndrome, Graves disease, high t4 syndrome, hyperthyroidism, hyperparathyroidism hypoadrenalism, hypoglycaemia, hypoparathyroidism, hypothyroidism, insulinoma, multiple endocrine neoplasia type 1, pheochromocytoma, pituitary dysfunction, postpartum thyroiditis, subacute thyroiditis
Environmental Nitrogen narcosis
Gastroenterologic Anorexia nervosa, carcinoid syndrome, celiac disease, chest pain, congenital hepatic porphyria, Crohn's disease, eating disorder, hepatic encephalopathy syndrome, hiatus hernia, irritable bowel syndrome, pellagra, ulcerative colitis, Wilson's disease
Genetic 22q11.2 deletion syndrome, acute intermittent porphyria, Asperger syndrome, celiac disease, chromosome 22q deletion, congenital heart disease, Crohn's disease, early-onset Alzheimer's disease, familial dysautonomia, Gulf War syndrome, heritable connective tissue disorders, velocardiofacial syndrome, WAGR syndrome
Hematologic Anemia
Iatrogenic Akathisia
Infectious Disease Brucellosis, cystitis, encephalitis, infectious mononucleosis, neurosyphilis, rabies, tetanus, toxic shock syndrome, variant Creutzfeldt-Jakob disease
Musculoskeletal / Ortho Tension myositis
Neurologic Aging brain syndrome, akathisia, Alzheimer disease, Asperger syndrome, autism, autoimmune limbic encephalitis, autonomic dysreflexia autonomic hyperreflexia, brain tumor, delirium, delirium tremens, dementia, early-onset Alzheimer's, encephalitis, familial dysautonomia, head injury, hepatic encephalopathy syndrome, Huntington's disease, hypersomnia, limbic encephalitis, multiple sclerosis, pellagra, post-concussion syndrome, Right parietal lobe syndrome, subarachnoid hemorrhage, temporal arteritis, temporal lobe epilepsy, vascular malformations of the brain, Wernicke-Korsakoff syndrome, Wilson's disease
Nutritional / Metabolic Acute intermittent porphyria, celiac disease, food additives, glycogen storage disease type 6, hyperglycemia, hypoglycaemia, inborn amino acid metabolism disorder, pellagra, Wernicke-Korsakoff syndrome, Wilson's disease
Obstetric/Gynecologic Menopause, postpartum depression, postpartum thyroiditis, premenstrual dysphoric disorder, premenstrual syndrome
Oncologic Adrenal tumor, brain tumor, carcinoid syndrome, insulinoma, paraneoplastic limbic encephalitis
Opthalmologic Oculogyric crisis, progressive external ophthalmoplegia, temporal arteritis
Overdose / Toxicity Alcohol intoxication, amphetamine abuse, barbiturate abuse, benzodiazepine abuse, caffeine addiction , chemical addiction, cocaine addiction, crack addiction, cyclosporine toxicity, ecstasy addiction, ginseng overdose, lidocaine toxicity, marijuana addiction, methamphetamine overdose, narcotic addiction
Psychiatric Abuse, Phonophobia, acrophobia, acute stress disorder, addiction, adjustment disorder, agoraphobia, alcohol withdrawal, anglophobia, anorexia nervosa, anthropophobia, antipsychotic (withdrawal), Asperger syndrome, attention deficit hyperactivity disorder, behavioral disorders, belonephobia, benzodiazepine withdrawal syndrome, bibliophobia, binge eating disorder, bipolar disorder, borderline personality disorder, bromidrosiphobia, bruxism, bulimia nervosa, cainophobia, cancerophobia, cardiophobia, cheimatophobia, cherophobia, child abuse, chrematophobia, chronic stress, claustrophobia, cocaine withdrawal, coitophobia, combat stress reaction, coulrophobia(fear of clowns), delirium tremens, dementia, demophobia
Pulmonary Airway obstruction, anaphylaxis, aspiration pneumonia, asthma, chest pain, chronic obstructive pulmonary disease, chronic respiratory failure, decreased oxygen saturation, diaphragmatic paralysis, emphysema, hyperoxia, hyperventilation syndrome, hyperventilation, pulmonary edema, pulmonary embolism, pneumonia, pneumothorax, respiratory alkalosis, stridor
Renal / Electrolyte Cystitis, Electrolyte disturbance, hematuria syndrome, lupus, Uremia
Rheum / Immune / Allergy 22q11.2 deletion syndrome, anaphylaxis, fibromyalgia, Graves disease, Gulf War syndrome, hypersensitivity to food, insect bite allergy, rheumatoid arthritis, lupus, paraneoplastic limbic encephalitis, polyarteritis nodosa, temporal arteritis, velocardiofacial syndrome, vitiligo, Wilson's disease
Sexual Female hysteria, neurosyphilis, puberty
Trauma Concussion, head injury,
Urologic hematuria syndrome, subarachnoid hemorrhage
Dental No underlying causes

Causes in Alphabetical Order


  1. Thobois S, Prange S, Sgambato-Faure V, Tremblay L, Broussolle E (2017). "Imaging the Etiology of Apathy, Anxiety, and Depression in Parkinson's Disease: Implication for Treatment". Curr Neurol Neurosci Rep. 17 (10): 76. doi:10.1007/s11910-017-0788-0. PMID 28822071.
  2. Tseng CC, Hu LY, Liu ME, Yang AC, Shen CC, Tsai SJ (2017). "Bidirectional association between Bell's palsy and anxiety disorders: A nationwide population-based retrospective cohort study". J Affect Disord. 215: 269–273. doi:10.1016/j.jad.2017.03.051. PMID 28359982.
  3. Pham T, Sauro KM, Patten SB, Wiebe S, Fiest KM, Bulloch A, Jetté N (2017). "The prevalence of anxiety and associated factors in persons with epilepsy". Epilepsia. 58 (8): e107–e110. doi:10.1111/epi.13817. PMID 28597927. Vancouver style error: initials (help)
  4. Mitsikostas DD, Ljubisavljevic S, Deligianni CI (2017). "Refractory burning mouth syndrome: clinical and paraclinical evaluation, comorbiities, treatment and outcome". J Headache Pain. 18 (1): 40. doi:10.1186/s10194-017-0745-y. PMC 5371535. PMID 28357703.
  5. Empty citation (help)

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