Diethylcathinone

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Diethylcathinone
Clinical data
Pregnancy
category
  • B
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC13H19NO
Molar mass241.76

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Overview

Diethylcathinone (also called Diethylpropion and Amfepramone), is a sympathomimetic stimulant drug marketed as an appetite suppressant. It is sold under the brand name Tenuate or Tenuate Dospan, and may also be known as Amfepramone. The popular antidepressant, Wellbutrin (bupropion) is an analogue of this chemical. Both diethylpropion and bupropion have a stimulant effect on the CNS.

Pharmacology

Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. Chemically, it is the N,N-diethyl analog of cathinone and dimethylcathinone. Diethylpropion is manufactured in 25 mg tablets and 75 mg controlled-release tablets (Tenuate®, Tepanil Ten-Tab®). Diethylpropion is classified as a Schedule IV controlled substance in the United States.

It is also used in the treatment of migraine (off-label).

Contraindications

  • Hypersensitivity to sympathomimetic amines
  • Advanced arteriosclerosis or symptomatic cardiovascular disease
  • Moderate or severe hypertension
  • Hyperthyroidism
  • History of drug abuse
  • MAO inhibitor use (within 14 days)

Side effects

Severe
  • Pulmonary hypertension
  • Stroke
  • Psychosis
Cardiovascular
  • Tachycardia, hypertension, arrhythmia, chest pain
Ear, nose, and throat
  • Xerostomia, metallic taste
Endocrine
  • Changes in libido, gynecomastia, menstrual irregularities
Eye
  • Blurred vision
Gastrointestinal
  • Nausea/vomiting, constipation, abdominal cramps
Hematological
  • Bone marrow depression, agranulocytosis, leukopenia
Neurological
  • Tremor
Psychological
  • Euphoria, agitation, nervousness, restlessness, dizziness, anxiety, headache, mental depression, seizures
Skin
  • Rash, hives, alopecia, ecchymosis
Urogenital and reproductive
  • Changes in libido, impotence

See also

References


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