IL13RA2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interleukin-13 receptor subunit alpha-2''' (IL-13Rα2), also known as '''CD213A2''' ([[cluster of differentiation]] 213A2), is a membrane bound [[protein]] that in humans is encoded by the ''IL13RA2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interleukin 13 receptor, alpha 2
| HGNCid = 5975
| Symbol = IL13RA2
| AltSymbols =; CD213A2; IL-13R; IL13BP
| OMIM = 300130
| ECnumber = 
| Homologene = 534
| MGIid = 1277954
| GeneAtlas_image1 = PBB_GE_IL13RA2_206172_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004907 |text = interleukin receptor activity}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3598
    | Hs_Ensembl = ENSG00000123496
    | Hs_RefseqProtein = NP_000631
    | Hs_RefseqmRNA = NM_000640
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 114144794
    | Hs_GenLoc_end = 114159792
    | Hs_Uniprot = Q14627
    | Mm_EntrezGene = 16165
    | Mm_Ensembl = ENSMUSG00000031289
    | Mm_RefseqmRNA = NM_008356
    | Mm_RefseqProtein = NP_032382
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 142629920
    | Mm_GenLoc_end = 142675560
    | Mm_Uniprot = 
  }}
}}
'''Interleukin 13 receptor, alpha 2''', also known as '''IL13RA2''' and '''CD213A2''' ([[cluster of differentiation]] 213A2), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
IL-13Rα2 is closely related to [[IL13RA1|IL-13Rα1]], a subunit of the [[interleukin-13 receptor]] complex. This protein binds [[interleukin 13|IL13]] with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and [[interleukin 4|IL-4]], despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.<ref name="entrez">{{cite web | title = Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3598| accessdate = }}</ref>
}}


==See also==
==See also==
Line 58: Line 10:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Andrews AL, Nasir T, Bucchieri F, etal |title=IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts |journal=J. Allergy Clin. Immunol. |volume=118 |issue= 4 |pages= 858–65 |year= 1996 |doi=10.1016/j.jaci.2006.06.041  | pmid=17030238 }}
| citations =
*{{cite journal   |vauthors=Caput D, Laurent P, Kaghad M, etal |title=Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16921–6 |year= 1996 |pmid= 8663118 |doi=10.1074/jbc.271.28.16921  }}
*{{cite journal | author=Caput D, Laurent P, Kaghad M, ''et al.'' |title=Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. |journal=J. Biol. Chem. |volume=271 |issue= 28 |pages= 16921-6 |year= 1996 |pmid= 8663118 |doi=  }}
*{{cite journal   |vauthors=Zhang JG, Hilton DJ, Willson TA, etal |title=Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9474–80 |year= 1997 |pmid= 9083087 |doi=10.1074/jbc.272.14.9474 }}
*{{cite journal | author=Zhang JG, Hilton DJ, Willson TA, ''et al.'' |title=Identification, purification, and characterization of a soluble interleukin (IL)-13-binding protein. Evidence that it is distinct from the cloned Il-13 receptor and Il-4 receptor alpha-chains. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9474-80 |year= 1997 |pmid= 9083087 |doi= }}
*{{cite journal   |vauthors=Gauchat JF, Schlagenhauf E, Feng NP, etal |title=A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor |journal=Eur. J. Immunol. |volume=27 |issue= 4 |pages= 971–8 |year= 1997 |pmid= 9130652 |doi=10.1002/eji.1830270425  }}
*{{cite journal | author=Gauchat JF, Schlagenhauf E, Feng NP, ''et al.'' |title=A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. |journal=Eur. J. Immunol. |volume=27 |issue= 4 |pages= 971-8 |year= 1997 |pmid= 9130652 |doi=  }}
*{{cite journal   |vauthors=Guo J, Apiou F, Mellerin MP, etal |title=Chromosome mapping and expression of the human interleukin-13 receptor |journal=Genomics |volume=42 |issue= 1 |pages= 141–5 |year= 1997 |pmid= 9177784 |doi= 10.1006/geno.1997.4628 }}
*{{cite journal | author=Guo J, Apiou F, Mellerin MP, ''et al.'' |title=Chromosome mapping and expression of the human interleukin-13 receptor. |journal=Genomics |volume=42 |issue= 1 |pages= 141-5 |year= 1997 |pmid= 9177784 |doi= 10.1006/geno.1997.4628 }}
*{{cite journal   |vauthors=Donaldson DD, Whitters MJ, Fitz LJ, etal |title=The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1 |journal=J. Immunol. |volume=161 |issue= 5 |pages= 2317–24 |year= 1998 |pmid= 9725226 |doi=  }}
*{{cite journal | author=Donaldson DD, Whitters MJ, Fitz LJ, ''et al.'' |title=The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. |journal=J. Immunol. |volume=161 |issue= 5 |pages= 2317-24 |year= 1998 |pmid= 9725226 |doi= }}
*{{cite journal   |vauthors=Osawa M, Miyoshi S, Copeland NG, etal |title=Characterization of the mouse interleukin-13 receptor alpha1 gene |journal=Immunogenetics |volume=51 |issue= 11 |pages= 974–81 |year= 2000 |pmid= 11003391 |doi=10.1007/s002510000225  }}
*{{cite journal | author=Osawa M, Miyoshi S, Copeland NG, ''et al.'' |title=Characterization of the mouse interleukin-13 receptor alpha1 gene. |journal=Immunogenetics |volume=51 |issue= 11 |pages= 974-81 |year= 2000 |pmid= 11003391 |doi=  }}
*{{cite journal  |vauthors=Kawakami K, Takeshita F, Puri RK |title=Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25114–20 |year= 2001 |pmid= 11352909 |doi= 10.1074/jbc.M100936200 }}
*{{cite journal | author=Kawakami K, Takeshita F, Puri RK |title=Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25114-20 |year= 2001 |pmid= 11352909 |doi= 10.1074/jbc.M100936200 }}
*{{cite journal  |vauthors=Daines MO, Hershey GK |title=A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10387–93 |year= 2002 |pmid= 11786536 |doi= 10.1074/jbc.M108109200 }}
*{{cite journal  | author=Daines MO, Hershey GK |title=A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10387-93 |year= 2002 |pmid= 11786536 |doi= 10.1074/jbc.M108109200 }}
*{{cite journal   |vauthors=Okano F, Storkus WJ, Chambers WH, etal |title=Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2851–5 |year= 2002 |pmid= 12231526 |doi= }}
*{{cite journal  | author=Okano F, Storkus WJ, Chambers WH, ''et al.'' |title=Identification of a novel HLA-A*0201-restricted, cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain. |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2851-5 |year= 2002 |pmid= 12231526 |doi= }}
*{{cite journal   |vauthors=Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, etal |title=Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1114–20 |year= 2003 |pmid= 12445201 |doi= 10.1046/j.1523-1747.2002.19509.x }}
*{{cite journal | author=Cancino-Díaz JC, Reyes-Maldonado E, Bañuelos-Pánuco CA, ''et al.'' |title=Interleukin-13 receptor in psoriatic keratinocytes: overexpression of the mRNA and underexpression of the protein. |journal=J. Invest. Dermatol. |volume=119 |issue= 5 |pages= 1114-20 |year= 2003 |pmid= 12445201 |doi= 10.1046/j.1523-1747.2002.19509.x }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=David M, Bertoglio J, Pierre J |title=TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression |journal=Ann. N. Y. Acad. Sci. |volume=973 |issue= |pages= 207–9 |year= 2003 |pmid= 12485861 |doi=10.1111/j.1749-6632.2002.tb04633.x  }}
*{{cite journal | author=David M, Bertoglio J, Pierre J |title=TNF-alpha potentiates IL-4/IL-13-induced IL-13Ralpha2 expression. |journal=Ann. N. Y. Acad. Sci. |volume=973 |issue= |pages= 207-9 |year= 2003 |pmid= 12485861 |doi=  }}
*{{cite journal  |vauthors=Wu AH, Low WC |title=Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter |journal=Neuro-oncology |volume=5 |issue= 3 |pages= 179–87 |year= 2003 |pmid= 12816724 |doi=   10.1215/s1152851702000510| pmc=1920687 }}
*{{cite journal  | author=Wu AH, Low WC |title=Molecular cloning and identification of the human interleukin 13 alpha 2 receptor (IL-13Ra2) promoter. |journal=Neuro-oncology |volume=5 |issue= 3 |pages= 179-87 |year= 2003 |pmid= 12816724 |doi= 10.1215/S1152-8517-02-00051-0 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Arima K, Sato K, Tanaka G, etal |title=Characterization of the interaction between interleukin-13 and interleukin-13 receptors |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24915–22 |year= 2005 |pmid= 15870068 |doi= 10.1074/jbc.M502571200 }}
*{{cite journal | author=Arima K, Sato K, Tanaka G, ''et al.'' |title=Characterization of the interaction between interleukin-13 and interleukin-13 receptors. |journal=J. Biol. Chem. |volume=280 |issue= 26 |pages= 24915-22 |year= 2005 |pmid= 15870068 |doi= 10.1074/jbc.M502571200 }}
*{{cite journal  |vauthors=Fichtner-Feigl S, Strober W, Kawakami K, etal |title=IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis |journal=Nat. Med. |volume=12 |issue= 1 |pages= 99–106 |year= 2006 |pmid= 16327802 |doi= 10.1038/nm1332 }}
*{{cite journal | author=Fichtner-Feigl S, Strober W, Kawakami K, ''et al.'' |title=IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. |journal=Nat. Med. |volume=12 |issue= 1 |pages= 99-106 |year= 2006 |pmid= 16327802 |doi= 10.1038/nm1332 }}
*{{cite journal  |vauthors=Daines MO, Tabata Y, Walker BA, etal |title=Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling |journal=J. Immunol. |volume=176 |issue= 12 |pages= 7495–501 |year= 2006 |pmid= 16751396 |doi= 10.4049/jimmunol.176.12.7495}}
*{{cite journal  | author=Daines MO, Tabata Y, Walker BA, ''et al.'' |title=Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling. |journal=J. Immunol. |volume=176 |issue= 12 |pages= 7495-501 |year= 2006 |pmid= 16751396 |doi=  }}
*{{cite journal   |vauthors=Kioi M, Kawakami M, Shimamura T, etal |title=Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy |journal=Cancer |volume=107 |issue= 6 |pages= 1407–18 |year= 2006 |pmid= 16902988 |doi= 10.1002/cncr.22134 }}
*{{cite journal | author=Kioi M, Kawakami M, Shimamura T, ''et al.'' |title=Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. |journal=Cancer |volume=107 |issue= 6 |pages= 1407-18 |year= 2006 |pmid= 16902988 |doi= 10.1002/cncr.22134 }}
*{{cite journal   |vauthors=Granel B, Allanore Y, Chevillard C, etal |title=IL13RA2 gene polymorphisms are associated with systemic sclerosis |journal=J. Rheumatol. |volume=33 |issue= 10 |pages= 2015–9 |year= 2007 |pmid= 16981293 |doi=  }}
*{{cite journal | author=Granel B, Allanore Y, Chevillard C, ''et al.'' |title=IL13RA2 gene polymorphisms are associated with systemic sclerosis. |journal=J. Rheumatol. |volume=33 |issue= 10 |pages= 2015-9 |year= 2007 |pmid= 16981293 |doi=  }}
}}
{{refend}}
{{refend}}


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* {{MeshName|IL13RA2+protein,+human}}
* {{MeshName|IL13RA2+protein,+human}}


{{membrane-protein-stub}}
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{{Clusters of differentiation}}
{{Clusters of differentiation}}
{{Interleukin receptor modulators}}
[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]
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Latest revision as of 20:31, 18 August 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interleukin-13 receptor subunit alpha-2 (IL-13Rα2), also known as CD213A2 (cluster of differentiation 213A2), is a membrane bound protein that in humans is encoded by the IL13RA2 gene.[1]

Function

IL-13Rα2 is closely related to IL-13Rα1, a subunit of the interleukin-13 receptor complex. This protein binds IL13 with high affinity, but lacks any significant cytoplasmic domain, and does not appear to function as a signal mediator. It is, however, able to regulate the effects of both IL-13 and IL-4, despite the fact it is unable to bind directly to the latter. It is also reported to play a role in the internalization of IL13.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: IL13RA2 interleukin 13 receptor, alpha 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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