Interleukin 22
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| Image:IL22 Crystal Structure.png | |
| Crystal structure of human IL-22 | |
| Interleukin 22
| |
| Identifiers | |
| Symbol | IL22 |
| Alt. Symbols | , ILTIF, zcyto18, IL-TIF, IL-D110, TIFa, TIFIL-23 |
| Entrez | 50616 |
| HUGO | 14900 |
| OMIM | 605330 |
| PDB | 1M4R |
| RefSeq | NM_020525 |
| UniProt | Q9GZX6 |
| Other data | |
| Locus | Chr. 12 q15 |
Interleukin-22 (IL-22) is a cytokine with homology to IL-10 that was originally called IL-10-related T cell-derived inducible factor (IL-TIF). Human IL-TIF activates the transcription factors stat-1 and stat-3 in several hepatoma cell lines and up-regulates production of acute phase proteins such as serum amyloid A, 1-antichymotrypsin and haptoglobin in HepG2 human hepatoma cells.[1] IL-22, signals through the interferon receptor-related proteins CRF2-4 and IL-22R.[2]
References
- ↑ Dumoutier L., Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl. Acad. Sci. U.S.A. 2000, Volume 97 pages 10144-10149.
- ↑ Xie et al., Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R, Journal of Biological Chemistry, 2000, Volume 275, page 31335-31339.
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Cytokines: interleukins | |
|---|---|
| IL-1 superfamily | IL-1 (IL-1Ra) - IL-18 - IL-33 |
| IL-6 like/gp130 utilizing | IL-6 - IL-11 - IL-27 - IL-30 - IL-31 |
| IL-10 family | IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26 |
| Interferon type III | IL-28 - IL-29 |
| Common γ-chain family | IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21 |
| IL-12 family | IL-12 - IL-23 - IL-27 - IL-35 |
| Other | IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32 |
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
