|Locus||Chr. 4 q31|
Interleukin 15 (IL-15) is a cytokine with structural similarity to IL-2 that is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
Maintenance of memory cells does not appear to require persistence of the original antigen; instead, survival signals for memory lymphocytes are provided by cytokines such as IL-15.
In transgenic mice that have the IL-15 receptor alpha (IL-15Ralpha) gene knocked out, natural killer cells cells do not develop.
In people with history of acute infectious mononucleosis (the syndrome associated with primary Epstein-Barr virus infection), IL-15R expressing lymphocytes are not detected--even 14 years after infection.
|IL-1 superfamily||IL-1 (IL-1Ra) - IL-18 - IL-33|
|IL-6 like/gp130 utilizing||IL-6 - IL-11 - IL-27 - IL-30 - IL-31|
|IL-10 family||IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26|
|Interferon type III||IL-28 - IL-29|
|Common γ-chain family||IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21|
|IL-12 family||IL-12 - IL-23 - IL-27 - IL-35|
|Other||IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32|
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies