Interleukin 11
| interleukin 11
| |
| Identifiers | |
| Symbol | IL11 |
| Entrez | 3589 |
| HUGO | 5966 |
| OMIM | 147681 |
| RefSeq | NP_000632 |
| UniProt | P20809 |
| Other data | |
| Locus | Chr. 19 q13.3-q13.4 |
Interleukin 11 (IL-11) is a cytokine (first isolated in 1990) that originates from bone marrow stroma and activates B cells and megakaryocytes.[1] It is also known under the names Adipogenesis inhibitory factor (AGIF)[2] and Oprelvekin.
Compared to other interleukins, IL-11 relatively under-characterized.
The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19.[3] IL-11 belongs to the IL-6 superfamily.
Functions
IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones.
References
- ↑ Paul,S.R., et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proceeding of the National Academy of Science U.S.A., 1990, Volume 87 pages 7512-7516.
- ↑ Kawashima,I et al., Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Letters, 1991, Volume 283, pages 199-202.
- ↑ McKinley et al., Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics, 1992, Volume 13, pages 814-819.
Cytokines: interleukins | |
|---|---|
| IL-1 superfamily | IL-1 (IL-1Ra) - IL-18 - IL-33 |
| IL-6 like/gp130 utilizing | IL-6 - IL-11 - IL-27 - IL-30 - IL-31 |
| IL-10 family | IL-10 - IL-19 - IL-20 - IL-22 - IL-24 - IL-26 |
| Interferon type III | IL-28 - IL-29 |
| Common γ-chain family | IL-2/IL-15 - IL-3 - IL-4 - IL-7 - IL-9 - IL-13 - IL-21 |
| IL-12 family | IL-12 - IL-23 - IL-27 - IL-35 |
| Other | IL-5 - IL-8 - IL-14 - IL-16 - IL-17/IL-25 (A) - IL-32 |
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