Ferroportin
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| solute carrier family 40 (iron-regulated transporter), member 1
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| Identifiers | |
| Symbol | SLC40A1 |
| Alt. Symbols | SLC11A3 FPN1 |
| Entrez | 30061 |
| HUGO | 10909 |
| OMIM | 604653 |
| RefSeq | NM_014585 |
| UniProt | Q9NP59 |
| Other data | |
| Locus | Chr. 2 q32 |
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US National Guidelines Clearinghouse on Ferroportin
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Ferroportin is a transmembrane protein that transports iron from the inside of a cell to the outside of it. It is found on the surface of cells that store or transport iron, including:
- Enterocytes in the duodenum
- Hepatocytes
- Macrophages of the reticuloendothelial system.
Recent research suggests that ferroportin is the key molecule regulated by hepcidin, the apparent "master regulator" of human iron metabolism.
Clinical significance
Ferroportin can be associated with African iron overload.
External links
de:Ferroportin
Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .

