SLC25A12

Solute carrier family 25 (mitochondrial carrier, Aralar), member 12
Identifiers
Symbol(s)	SLC25A12; ARALAR; ARALAR1
External IDs	OMIM: 603667 MGI: 1926080 Homologene: 48235
Gene ontology Molecular Function: • transporter activity • binding • calcium ion binding • solute:cation symporter activity Cellular Component: • mitochondrion • mitochondrial inner membrane • integral to plasma membrane • membrane Biological Process: • transport
RNA expression pattern
250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	8604	78830
Ensembl	ENSG00000115840	ENSMUSG00000027010
Uniprot	O75746	Q8BH59
Refseq	NM_003705 (mRNA) NP_003696 (protein)	NM_172436 (mRNA) NP_766024 (protein)
Location	Chr 2: 172.35 - 172.46 Mb	Chr 2: 71.07 - 71.17 Mb
Pubmed search	[1]	[2]

Solute carrier family 25 (mitochondrial carrier, Aralar), member 12, also known as SLC25A12, is a human gene.

See also

• Solute carrier family

Further reading

• del Arco A, Satrústegui J (1998). "Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain.". J. Biol. Chem. 273 (36): 23327-34. PMID 9722566.
• Kobayashi K, Sinasac DS, Iijima M, et al. (1999). "The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.". Nat. Genet. 22 (2): 159-63. doi:10.1038/9667. PMID 10369257.
• Crackower MA, Sinasac DS, Lee JR, et al. (2000). "Assignment of the SLC25A12 gene coding for the human calcium-binding mitochondrial solute carrier protein aralar to human chromosome 2q24.". Cytogenet. Cell Genet. 87 (3-4): 197-8. PMID 10702666.
• Sanz R, del Arco A, Ayuso C, et al. (2000). "Assignment of the calcium-binding mitochondrial carrier Aralar1 gene (SLC25A12) to human chromosome band 2q31 by in situ hybridization.". Cytogenet. Cell Genet. 89 (3-4): 143-4. PMID 10965105.
• Palmieri L, Pardo B, Lasorsa FM, et al. (2001). "Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.". EMBO J. 20 (18): 5060-9. doi:10.1093/emboj/20.18.5060. PMID 11566871.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
• Ramoz N, Reichert JG, Smith CJ, et al. (2004). "Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism.". The American journal of psychiatry 161 (4): 662-9. PMID 15056512.
• Rubi B, del Arco A, Bartley C, et al. (2005). "The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells.". J. Biol. Chem. 279 (53): 55659-66. doi:10.1074/jbc.M409303200. PMID 15494407.
• Rabionet R, McCauley JL, Jaworski JM, et al. (2006). "Lack of association between autism and SLC25A12.". The American journal of psychiatry 163 (5): 929-31. doi:10.1176/appi.ajp.163.5.929. PMID 16648338.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
• Hong CJ, Liou YJ, Liao DL, et al. (2007). "Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia.". Prog. Neuropsychopharmacol. Biol. Psychiatry 31 (7): 1510-3. doi:10.1016/j.pnpbp.2007.07.010. PMID 17693006.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.