SLC4A4

Solute carrier family 4, sodium bicarbonate cotransporter, member 4
Identifiers
Symbol(s)	SLC4A4; DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC
External IDs	OMIM: 603345 MGI: 1927555 Homologene: 55776
Gene ontology Molecular Function: • inorganic anion exchanger activity • sodium:bicarbonate symporter activity • symporter activity • sodium ion binding Cellular Component: • integral to plasma membrane • membrane • integral to membrane Biological Process: • sodium ion transport • anion transport
RNA expression pattern
250px 250px 250px More reference expression data
Orthologs
	Human	Mouse
Entrez	8671	54403
Ensembl	ENSG00000080493	ENSMUSG00000060961
Uniprot	Q9Y6R1	O88343
Refseq	NM_003759 (mRNA) NP_003750 (protein)	NM_018760 (mRNA) NP_061230 (protein)
Location	Chr 4: 72.27 - 72.66 Mb	Chr 5: 90.01 - 90.31 Mb
Pubmed search	[1]	[2]

Solute carrier family 4, sodium bicarbonate cotransporter, member 4, also known as SLC4A4, is a human gene.

Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM]

See also

• Solute carrier family

Further reading

• Romero MF, Boron WF (1999). "Electrogenic Na+/HCO3- cotransporters: cloning and physiology.". Annu. Rev. Physiol. 61: 699-723. doi:10.1146/annurev.physiol.61.1.699. PMID 10099707.
• Soleimani M, Burnham CE (2000). "Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes.". Kidney Int. 57 (2): 371-84. doi:10.1046/j.1523-1755.2000.00857.x. PMID 10652014.
• Burnham CE, Amlal H, Wang Z, et al. (1997). "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter.". J. Biol. Chem. 272 (31): 19111-4. PMID 9235899.
• Abuladze N, Lee I, Newman D, et al. (1998). "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter.". J. Biol. Chem. 273 (28): 17689-95. PMID 9651366.
• Choi I, Romero MF, Khandoudi N, et al. (1999). "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC).". Am. J. Physiol. 276 (3 Pt 1): C576-84. PMID 10069984.
• Igarashi T, Inatomi J, Sekine T, et al. (1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities.". Nat. Genet. 23 (3): 264-6. doi:10.1038/15440. PMID 10545938.
• Pushkin A, Yip KP, Clark I, et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase.". Am. J. Physiol. 277 (6 Pt 2): F974-81. PMID 10600945.
• Park K, Hurley PT, Roussa E, et al. (2002). "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands.". Arch. Oral Biol. 47 (1): 1-9. PMID 11743927.
• Gross E, Hawkins K, Pushkin A, et al. (2002). "Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells.". J. Physiol. (Lond.) 537 (Pt 3): 659-65. PMID 11744745.
• Gross E, Pushkin A, Abuladze N, et al. (2003). "Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding.". J. Physiol. (Lond.) 544 (Pt 3): 679-85. PMID 12411514.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
• Tatishchev S, Abuladze N, Pushkin A, et al. (2003). "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation.". Biochemistry 42 (3): 755-65. doi:10.1021/bi026826q. PMID 12534288.
• Gross E, Fedotoff O, Pushkin A, et al. (2004). "Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini.". J. Physiol. (Lond.) 549 (Pt 3): 673-82. doi:10.1113/jphysiol.2003.042226. PMID 12730338.
• Sun XC, Bonanno JA (2003). "Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium.". Exp. Eye Res. 77 (3): 287-95. PMID 12907161.
• Yamada H, Yamazaki S, Moriyama N, et al. (2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma.". Biochem. Biophys. Res. Commun. 310 (4): 1213-8. PMID 14559244.
• Alvarez BV, Loiselle FB, Supuran CT, et al. (2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter.". Biochemistry 42 (42): 12321-9. doi:10.1021/bi0353124. PMID 14567693.
• Becker HM, Deitmer JW (2004). "Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes.". J. Biol. Chem. 279 (27): 28057-62. doi:10.1074/jbc.M402401200. PMID 15123668.
• Pushkin A, Abuladze N, Gross E, et al. (2005). "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells.". J. Physiol. (Lond.) 559 (Pt 1): 55-65. doi:10.1113/jphysiol.2004.065110. PMID 15218065.

Template:Membrane-protein-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.